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Autoimmune gastritis and antigenic mimicking

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Helicobacter pylori

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Abstract

Autoimmune gastritis is defined as a chronic atrophic gastritis of the corpus-fundus mucosa, which is associated with diffuse atrophy of the oxyntic mucosa and thus accompanying achlorhydria1. The presence of serum antibodies directed against parietal cell antigens and intrinsic factor is a specific feature of the disease. The advanced phases of this immunopathological spectrum are often associated with pernicious anaemia, a condition resulting from the impaired absorption of vitamin B12 caused by the unavailability of intrinsic factor2.

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References

  1. Cappella C, Fiocca R, Cornaggia M, Rindi G, Moratti R, Solcia E. Autoimmune gastritis. In: Graham DY, Genta RM, Dixon MF, editors. Gastritis. Philadelphia: Lippincott, Williams & Wilkins; 1999:79–96.

    Google Scholar 

  2. Wittingham S, Mackay IR. Pernicious anemia and gastric atrophy. In: Rose NR, Mackay IR, editors. The Autoimmune Diseases. London: Academic Press; 1985:243–245.

    Google Scholar 

  3. Karlsson FA, Burman P, Loof L, Mardh S. Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid producing H,K adenosine triphosphatase of the stomach. J Clin Invest. 1988;81:475–479.

    Article  PubMed  CAS  Google Scholar 

  4. Toh BA, van Driel IR, Gleeson PA. Autoimmune gastritis: tolerance and autoimmunity to the gastric H/K-ATPase (proton pump). Autoimmunity. 1992;13:165–172.

    Article  PubMed  CAS  Google Scholar 

  5. Fukuma K, Sakaguchi S, Kuribayashi K et al. Immunologie and clinical studies on murine experimental autoimmune gastritis induced by neonatal thymectomy. Gastroenterology. 1998;94:274–283.

    Google Scholar 

  6. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastric and peptic ulcération. Lancet. 1984;1:1311–1315.

    Article  PubMed  CAS  Google Scholar 

  7. Graham DY, Dixon MF. Acid secretion, Helicobacter pylori infection, and peptic ulcer disease. In: Graham DY, Genta RM, Dixon MF, editors. Gastritis. Philadelphia: Lippincott/Williams & Wilkins; 1999:177–187.

    Google Scholar 

  8. Figura N, Valassina M. Helicobacter pylori determinants of pathogenicity. J Chemother. 1999;11:591–600.

    PubMed  CAS  Google Scholar 

  9. Shimoyama T, Crabtree JE. Bacterial factors and immune pathogenesis in Helicobacter pylori infection. Gut. 1998;43(Suppl. 1):S2–5.

    Article  PubMed  Google Scholar 

  10. Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R. Helicobacter pylori virulence and genetic geography. Science. 1999;284:1328–1333.

    Article  PubMed  CAS  Google Scholar 

  11. Gonzalez JD, Sancho FJ, Sainz S, Such J, Fernandez M, Mones Xiol Y. Helicobacter pylori and pernicious anemia. Lancet. 1988;1:57.

    Google Scholar 

  12. Faisal MA, Russel RM, Samloff IM, Holt PR. Helicobacter pylori infection in atrophic gastritis in the elderly. Gastroenterology. 1990;99:1543–1544.

    PubMed  CAS  Google Scholar 

  13. Karnes WE, Samloff IM, Siurala M et al. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 1991;101:167–174.

    PubMed  Google Scholar 

  14. Stolte M. Autoimmune gastritis via mimicking does occur. Chapter 30, this volume.

    Google Scholar 

  15. Negrini R, Savio A, Poiesi C et al Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis. Gastroenterology. 1996;111:655–665.

    Article  PubMed  CAS  Google Scholar 

  16. Clayes D, Faller G, Appelmelk BJ, Negrini R. The gastric H+, K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy. Gastroenterology. 1998;115:340–347.

    Article  Google Scholar 

  17. Appelmelk BJ, Faller G, Clayes D, Kirchner T, Vandenbroucke-Grauls CMJE. Bugs on trial: the case of Helicobacter pylori and autoimmunity. Immunol Today. 1998;19:296–299.

    Article  PubMed  CAS  Google Scholar 

  18. Albert LJ, Inman RD. Molecular mimicry and autoimmunity. N Engl J Med. 1999;341:2068–2074.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. F. Franceschi
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  2. R. M. Genta
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine Director) (Professor of Medicine Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 2000 Springer Science+Business Media Dordrecht

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Franceschi, F., Genta, R.M. (2000). Autoimmune gastritis and antigenic mimicking. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_31

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  • DOI: https://doi.org/10.1007/978-94-011-3927-4_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5753-0

  • Online ISBN: 978-94-011-3927-4

  • eBook Packages: Springer Book Archive

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