Musculoskeletal aching and concomitant soft-tissue rheumatism are the most common rheumatic disorders. They are rarely identified as “diseases” or “disorders” in population surveys because of the difficulty in reliable diagnosis1,2 . Clinicians have similar troubles. Pain in the arm, leg, buttock, or chest, for example, is often difficult to understand and explain, and can be attributed to disk disorders, neuritis, bursitis, tendonitis, myositis, arthritis, myofascial pain, and psychologic disturbance. Few validation studies relating to diagnostic accuracy have been performed in these conditions and, although they remain common in the clinic, their vagueness and lack of adequate definition and validated criteria has generally excluded them as subjects for valued research.


Irritable Bowel Syndrome Rheumatic Disease Fibromyalgia Syndrome Fibromyalgia Patient Primary Fibromyalgia 
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  1. 1.
    Cobb, S. (1971). The Frequency of Rheumatic Diseases. (Cambridge, Mass.: Harvard University Press).Google Scholar
  2. 2.
    Lawrence, R. C., Hochberg, M. C., Kelsey, J. L. et al (1989). Estimates of the prevelance of selected arthritic and musculoskeletal diseases in the United States. J. Rheumatol, 16, 427–441.PubMedGoogle Scholar
  3. 3.
    Goldenberg, D. L. (1986). Psychologic studies in fibrositis. Am. J. Med., 81, 67–70.PubMedCrossRefGoogle Scholar
  4. 4.
    Hawley, D. J. and Wolfe, F. (1988). Anxiety and depression in patients with RA: A prospective study of 400 patients. J. Rheumatol., 15, 932–941.PubMedGoogle Scholar
  5. 5.
    Payne, T. C., Leavitt, D. C., Garron, D. C. et al. (1982). Fibrositis and psychologic disturbance. Arthritis Rheum., 25, 213–217.PubMedCrossRefGoogle Scholar
  6. 6.
    Scudds, R. A., Rollman, G. B., Harth, M. and McCain, G. A. (1987). Pain perception and personality measures as discriminators in the classification of fibrositis. J. Rheumatol., 14, 563–569.PubMedGoogle Scholar
  7. 7.
    Wolfe, F., Cathey, M. A., Kleinheksel, S. M. et al. (1984). Psychological status in primary fibrositis and fibrositis associated with rheumatoid arthritis. J. Rheumatol, 11, 500–506.PubMedGoogle Scholar
  8. 8.
    Wolfe, F. (1990). Methodologic and statistical problems in the epidemiology of fibromyalgia. In Ewad, E. and Fricton, J. R. (eds.) Myofascial Pain and Fibromyalgia, Chap. 8, pp. 147–163. (New York: Raven Press).Google Scholar
  9. 9.
    Yunus, M. B., Masi, A. T., Calabro, J. J., Miller, K. A. and Feigenbaum, S. L. (1981). Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls. Semin. Arthritis Rheum., 11, 151–171.PubMedCrossRefGoogle Scholar
  10. 10.
    Bennett, R. M. (1987). Fibromyalgia (editorial). J. Am. Med. Assoc, 257, 2802–2803.CrossRefGoogle Scholar
  11. 11.
    Goldenberg, D. L. (1987). Fibromyalgia syndrome. An emerging but controversial condition. J. Am. Med. Assoc, 257, 2782–2787.CrossRefGoogle Scholar
  12. 12.
    Cathey, M. A., Wolfe, F., Kleinheksel, S. M. and Hawley, D. J. (1986). Socioeconomic impact of fibrositis. A study of 81 patients with primary fibrositis. Am. J. Med., 81, 78–84.PubMedCrossRefGoogle Scholar
  13. 13.
    Hawley, D. J., Wolfe, F. and Cathey, M. A. (1988). Pain, functional disability, and psychological status: a 12 month study of severity in fibromyalgia. J. Rheumatol., 15, 1551–1556.PubMedGoogle Scholar
  14. 14.
    Bengtsson, A., Henriksson, K. G., Jorfeldt, L., Kagedal, B., Lennmarken, C. and Lindstrom, F. (1986). Primary fibromyalgia. A clinical and laboratory study of 55 patients. Scand. J. Rheumatol, 15, 340–347.PubMedCrossRefGoogle Scholar
  15. 15.
    Jacobsen, S. and Danneskiold Samse, B. (1987). Isometric and isokinetic muscle strength in patients with fibrositis syndrome. New characteristics for a difficult definable category of patients. Scand. J. Rheumatol, 16, 61–65.PubMedGoogle Scholar
  16. 16.
    Wolfe, F. (1986). The clinical syndrome of fibrositis. Am. J. Med., 81, 7–14.PubMedCrossRefGoogle Scholar
  17. 17.
    Wolfe, F., Hawley, D. J., Cathey, M. A., Caro, X. and Russel, I. J. (1985). Fibrositis: symptom frequency and criteria for diagnosis. An evaluation of 291 rheumatic disease patients and 58 normal individuals. J. Rheumatol, 12, 1159–1163.PubMedGoogle Scholar
  18. 18.
    Wolfe, F. and Cathey, M. A. (1985). The epidemiology of tender points: A prospective study of 1520 patients. J. Rheumatol, 12, 1164–1168.PubMedGoogle Scholar
  19. 19.
    Wolfe, F., Cathey, M. A. and Kleinheksel, S. M. (1984). Fibrositis (fibromyalgia) in rheumatoid arthritis. J. Rheumatol., 11, 814–818.PubMedGoogle Scholar
  20. 20.
    Wolfe, F. and Cathey, M. A. (1983). Prevalence of primary and secondary fibrositis. J. Rheumatol., 10, 965–968.PubMedGoogle Scholar
  21. 21.
    Dinerman, H., Goldenberg, D. L. and Felson, D. T. (1986). A prospective evaluation of 118 patients with the fibromyalgia syndrome: prevalence of Raynaud’s phenomenon, sicca symptoms, ANA, low complement, and 1g deposition at the dermalepidermal junction. J. Rheumatol., 13, 368–373.PubMedGoogle Scholar
  22. 22.
    Felson, D. T. and Goldenberg, D. L. (1986). The natural history of fibromyalgia. Arthritis Rheum., 29, 1522–1526.PubMedCrossRefGoogle Scholar
  23. 23.
    Simms, R. W., Goldenberg, D. L., Felson, D. T. and Mason, J. H. (1988). Tenderness in 75 anatomic sites. Distinguishing fibromyalgia patients from controls. Arthritis Rheum., 31, 182–187.PubMedCrossRefGoogle Scholar
  24. 24.
    Ahles, T. A., Yunus, M. B., Riley, S. D., Bradley, J. M. and Masi, A. T. (1984). Psychological factors associated with primary fibromyalgia syndrome. Arthritis Rheum., 27, 1101–1106.PubMedCrossRefGoogle Scholar
  25. 25.
    Campbell, S. M., Clark, S., Tindall, E. A., Forehand, M. E. and Bennett, R. M (1983). Clinical characteristics of fibrositis. I. A “blinded,” controlled study of symptoms and tender points. Arthritis Rheum., 26, 817–824.PubMedCrossRefGoogle Scholar
  26. 26.
    Clark, S., Campbell, S. M., Forehand, M. E., Tindall, E. A. and Bennett, R. M. Clinical characteristics of fibrositis. II. A “blinded,” controlled study using standard psychological tests. Arthritis Rheum., 28, 132-137.Google Scholar
  27. 27.
    Littlejohn, G. O., Weinstein, C. and Helme, R. D. (1987). Increased neurogenic inflammation in fibrositis syndrome. J. RheumatoL, 14, 1022–1025.PubMedGoogle Scholar
  28. 28.
    Bennett, R. M., Gatter, R. A., Campbell, S. M., Andrews, R.-P., Clark, S. R. and Scarola, J. A. (1988). A comparison of cyclobenzaprine and placebo in the management of fibrositis: A double-blind controlled study. Arthritis Rheum., 31, 1535–1542.PubMedCrossRefGoogle Scholar
  29. 29.
    Clark, S., Tindall, E. and Bennett, R. M. (1985). A double blind crossover trial of prednisone versus placebo in the treatment of fibrositis. J. Rheumatol., 12, 980–983.PubMedGoogle Scholar
  30. 30.
    McCain, G. A., Bell, D. A., Mai, F. M. and Halliday, P. D. (1988). A controlled study of the effects of a supervised cardiovascular fitness training program on the manifestations of fibromyalgia. Arthritis Rheum., 31, 1135–1141.PubMedCrossRefGoogle Scholar
  31. 31.
    Yunus, M. B., Masi, A. T. and Aldag, J. C. (1989). Short term effects of ibuprofen in primary fibromyalgia syndrome: A double blind, placebo controlled trial. J. Rheumatol., 16, 527–532.PubMedGoogle Scholar
  32. 32.
    Carette, S., McCain, G. A., Bell, D. A. and Fam, A. G. (1986). Evaluation of amitriptyline in primary fibrositis. A double-blind, placebo-controlled study. Arthritis Rheum., 29, 655–659.PubMedCrossRefGoogle Scholar
  33. 33.
    Goldenberg, D. L., Felson, D. T. and Dinerman, H. (1986). A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. Arthritis Rheum., 29, 1371–1377.PubMedCrossRefGoogle Scholar
  34. 34.
    Smythe, H. A. and Moldofsky, H. (1977). Two contributions to understanding of the “fibrositis” syndrome. Bull. Rheum. Dis., 28, 928–931.PubMedGoogle Scholar
  35. 35.
    Wolfe, F., Smythe, H. A., Yunus, M. B. et al. (1990). The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum., 33, 160–172.PubMedCrossRefGoogle Scholar
  36. 36.
    Bennett, R. M. (1981). Fibrositis: misnomer for a common rheumatic disorder. West. J. Med., 134, 405–413.PubMedGoogle Scholar
  37. 37.
    Yunus, M. B. and Masi, A. T. (1985). Juvenile primary fibromyalgia syndrome. A clinical study of thirty-three patients and matched normal controls. Arthritis Rheum., 28, 138–145.PubMedCrossRefGoogle Scholar
  38. 38.
    Calabro, J. J. and Perry, R. F. (1986). Juvenile primary fibromyalgia syndrome [letterJ. Arthritis Rheum., 29, 452–453.PubMedCrossRefGoogle Scholar
  39. 39.
    Buchwald, D., Goldenberg, D. L., Sullivan, J. L. and Komaroff, A. L. (1987). The “chronic, active Epstein-Barr virus infection” syndrome and primary fibromyalgia. Arthritis Rheum., 30, 1132–1136.PubMedCrossRefGoogle Scholar
  40. 40.
    Littlejohn, G. E. (1986). Repetitive strain syndrome: an Australian experience (editorial). J. Rheumatol., 13, 1004–1006.PubMedGoogle Scholar
  41. 41.
    Littlejohn, G. O. (1989). Fibrositis/fibromyalgia in the workplace. Rheum. Dis. Clin. N. Am., 15, 45–60.Google Scholar
  42. 42.
    Mason, J. H., Simms, R. W., Goldenberg, D. L. and Meenan, R. F. (1989). The impact of fibromyalgia on work: a comparison with RA. Arthritis Rheum., 32, S197–S197 (Abstract).Google Scholar
  43. 43.
    Fries, J. F. (1984). The chronic disease data bank: first principles to future directions. J. Med. Philos., 9, 161–180.PubMedCrossRefGoogle Scholar
  44. 44.
    Wolfe, F. (1989). A brief health status instrument: CLINHAQ. Arthritis Rheum., 32, S99 (Abstract).Google Scholar
  45. 45.
    Leavitt, F., Katz, R. S., Golden, H. E., Glickman, P. B. and Layfer, L. F. (1986). Comparison of pain properties in fibromyalgia patients and rheumatoid arthritis patients. Arthritis Rheum., 29, 775–781.PubMedCrossRefGoogle Scholar
  46. 46.
    Smythe, H. A. (1984). Problems with the MMPI [editorial]. J. Rheumatol, 11, 417–418.PubMedGoogle Scholar
  47. 47.
    Pincus, T., Callahan, L. F., Bradley, L. A. and Wolfe, F. (1986). Elevated MMPI scores for hypochondriasis, depression and hysteria in patients with rheumatoid arthritis reflect disease rather than psychological status. Arthritis Rheum., 29, 1456–1466.PubMedCrossRefGoogle Scholar
  48. 48.
    Leavitt, F. and Katz, R. S. (1989). Is the MMPI invalid for assessing psychological disturbance in pain related organic conditions. J. Rheumatol., 16, 521–526.PubMedGoogle Scholar
  49. 49.
    Drossman, D. A., McKee, D. C., Sandier, R. S., Mitchell, C. M., Lowman, B. C. and Burger, A. L. (1988). Psychosocial factors in the irritable bowel syndrome. Gastroenterology, 95, 701–708.PubMedGoogle Scholar
  50. 50.
    Whitehead, W. E., Bosmajian, L., Zonderman, A. B., Costa, Jr., P. G. and Schuster, M. M. (1988). Symptoms of psychologic distress associated with irritable bowel syndrome. Gastroenterology, 95, 709–714.PubMedGoogle Scholar
  51. 51.
    Cathey, M. A., Wolfe, F., Kleinheksel, S. M., Miller, S. and Pitetti, K. H. (1988). Functional ability and work status in patients with fibromyalgia. Arthritis Care Res., 1, 85–98.CrossRefGoogle Scholar
  52. 52.
    Bennett, R. M., Clark, S. R., Goldberg, L. et al. (1989). Aerobic fitness in patients with fibrositis: A controlled study of respiratory gas exchange and 133xenon clearance from exercising muscle. Arthritis Rheum., 32, 454–460.PubMedCrossRefGoogle Scholar
  53. 53.
    Caro, X. J. (1986). Immunofluorescent studies of skin in primary fibrositis syndrome. Am. J. Med., 81, 43–49.PubMedCrossRefGoogle Scholar
  54. 54.
    Kramer, J. S., Yelin, E. H. and Epstein, W. V. (1983). Social and economic impacts of four musculoskeletal conditions. Arthritis Rheum., 26, 901–907.PubMedCrossRefGoogle Scholar
  55. 55.
    Hartz, A. and Kirchdoerfer, E. (1987). Undetected fibrositis in primary care practice. J. Fam. Pract., 25, 365–369.PubMedGoogle Scholar
  56. 56.
    Goldenberg, D. L. (1989). Treatment of fibromyalgia syndrome. Rheum. Dis. Clin. N. Am., 15, 61–71.Google Scholar
  57. 57.
    Wolfe, F. (1988). Fibromyalgia: whither treatment? J. Rheumatol, 15, 1047–1049PubMedGoogle Scholar

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© Springer Science+Business Media Dordrecht 1991

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  • F. Wolfe

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