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References
Main references
Agoston S, Vermeer GA, Kersten UW, Mijer DKF: The fate of pancuronium bromide in man. Acta Anaesthesiol Scand 17:267, 1973
Agoston S, Crul JF, Kersten UW, Scat AHJ: Relationship of the serum concentration of pancuronium to its neuromuscular activity in man. Anesthesiology 47:509, 1977
Bevan DR, Archer D, Donati F et al.: Antagonism of pancuronium in renal failure: No recurarization. Br J Anaesth 54:63, 1982
Buzello W: Der Stoffwechsel von Pancuronium beim Menschen. Anaesthesist 24:13, 1975
Buzello W, Ruthven-Murray J: Der Konzentrationsverlauf von Pancuronium im Serum anurischer Patienten. Anaesthesist 25:440, 1976
Duvaldestin P, Agoston S, Henzel D et al.: Pancuronium pharmacokinetics in patients with liver cirrhosis. Br J Anaesth 50:1131, 1978
Hunter JM, Jones RS, Utting JE: Comparison of vecuronium, atracurium and tubocurarine in normal patients and in patients with no renal function. Br J Anaesth 56:941, 1984
Kamvyssi-Dea S, Papdimitriou K, Dousaitou P: The use of pancuronium bromide in operations for renal insufficiency. Case reports. Br J Anaesth 44:1217, 1972
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:1236, pancuronium bromide.
McLeod K, Watson MJ, Rawlins MD: Pharmacokinetics of pancuronium in patients with normal and impaired renal function. Br J Anaesth 48:341, 1976
Miller RD, Cullen DJ: Renal failure and postoperative respiratory failure: Recurarization? Br J Anaesth 48:253, 1976
Miller RD, Agoston S, Booij L, Kersten UW, Crul JF, Ham J: The comparative potency and pharmacokinetics of pancuronium and its metabolites in anesthetized man. J Pharmacol Exp Ther 207:539, 1978
Roizen MF, Feeley TW: Pancuronium bromide. Ann Intern Med 88:64, 1978
Somogyi AA, Shanks CA, Triggs EJ: Clinical pharmacokinetics of pancuronium bromide. Eur J Clin Pharmacol 10:367, 1976
Somogyi AA, Shanks CA, Triggs EJ: Disposition kinetics of pancuronium bromide in patients with total biliary obstruction. Br J Anaesth 49:1103, 1977
Somogyi AA, Shanks CA, Triggs EJ: The effect of renal failure on the disposition and neuromuscular blocking action of pancuronium bromide. Eur J Clin Pharmacol 12:23, 1977
Wingard LB, Cook DR: The clinical pharmacokinetics of tubocurarine chloride. Clin Pharmacokinet 2:330, 1977
Main references
Feldman HA, Singer I: Endocrinology and metabolism in uremia and dialysis: A clinical review. Medicine 54:345, 1974
Kopple JD, Swendseid ME: Vitamin nutrition in patients undergoing maintenance hemodialysis. Kidney Int 7 (Suppl 2):S79, 1975
Stein G, Sperschneider H, Koppe S: Vitamin levels in chronic renal failure and need for supplementation. Blood Purif 3:52, 1985
Main references
Axelrod J, Shofer R, Inscoe JK et al.: The fate of papaverine in man and other mammals. J Pharmacol Exp Ther 124:9, 1958
Belpaire FM, Rosseel MT, Bogaert MG: Metabolism of papaverine. IV. Urinary elimination of papaverine metabolites in man. Xenobiotica 8:297, 1978
Boley SJ, Brandt LJ, Veith FJ: Ischemic disorders of the intestines. Curr Probl Surg 15(4): 1, 1978
Herrschaft H: The efficacy and course of action of vaso- and metabolic-active substances on regional cerebral blood flow in patients with cerebral ischemia. Arzneimittelforschung (Drug Res) 26:1240, 1976
Ritschel WA, Hammer GV: Pharmacokinetics of papaverine in man. Int J Clin Pharmacol 15:227, 1977
Main references
Ameer B, Greenblatt DJ: Acetaminophen. Ann Intern Med 87:202, 1977
Cobden I, Record CO, Ward MK, Kerr DNS: Paracetamol-induced acute renal failure in the absence of fulminant liver damage. Br Med J 284:21, 1982
Davis M, Simmons CJ, Harrison NG, Williams R: Paracetamol overdose in man: Relationship between pattern of urinary metabolites and severity of liver damage. Q J Med 45:181, 1976
Forrest JA, Clements JA, Prescott LF: Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet 7:93, 1982
Hunt CA, Dunford PR: Acetaminophen. J Am Pharm Assoc 17:517, 1977
Kincaid-Smith P: Analgesic abuse and the kidney. Kidney Int 17:250, 1980
Lee CS, Wang LH, Marbury TC, Cade JR: Hemodialysis for acetaminophen detoxification. J Toxicol Clin Toxicol 18:431, 1981
Levy G: Comparative pharmacokinetics of aspirin and acetaminophen. Arch Intern Med 141:279, 1981
Marbury TC, Wang LH, Lee CS: Hemodialysis of acetaminophen in uremic patients. Int J Artif Organs 3:263, 1980
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:32, paracetamol.
Morris ME, Levy G: Serum concentration and renal excretion by normal adults of inorganic sulfate after acetaminophen, ascorbic acid, or sodium sulfate. Clin Pharmacol Ther 33:529, 1983
Oie S, Lowenthal DT, Briggs WA, Levy G: Effect of hemodialysis on kinetics of acetaminophen elimination by anephric patients. Clin Pharmacol Ther 18:680, 1975
Pimstone BL, Uys CJ: Liver necrosis and myocardiopathy following paracetamol overdosage. S Afr Med J 42:259, 1968
Prescott LF, Critchley GA, Balali-Mood M, Pentland B: Effects of microsomal enzyme induction on paracetamol metabolism in man. Br J Clin Pharmacol 12:149, 1981
Main references
Gutman RA, Burnell JM: Paraldehyde acidosis. Am J Med 42:435, 1967
Kittel J: Paraldehyde toxicity. Hosp Pharm 8:263, 1973
Seyffart G: Paraldehyde. In: Haddad LM, Winchester JF (eds): Clinical management of poisoning and drug overdose. Philadelphia: Saunders, 1983 p 410
Waterhouse C, Stern EA: Metabolic acidosis occurring during administration of paraldehyde. Am J Med 23:987, 1957
Main references
Heymann W: Nephrotic syndrome after use of trimethadione and paramethadione in petit mal. JAMA 202:893, 1967
Hoffman DJ, Chun AH: Paramethadione and metabolite serum levels in humans after single oral paramethadione dose. J Pharm Sci 64:1702, 1975
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:493, pargyline hydrochloride.
Main references
Barre J, Houin G, Tillement JP: Dose-dependent pharmacokinetic study of Pefloxacin, a new antibacterial agent, in humans. J Pharm Sci 73:1379, 1984
Höffler D, Schäfer J, Koeppe P, Sörgel F: Pharmacokinetics of Pefloxacin in normal and impaired renal function. Arzneimittelforschung (Drug Res) 38 (l):739, 1988
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:281, Pefloxacin.
Montay G, Goueffon Y, Roquet F: Absorption, distribution, metabolic fate, and elimination of Pefloxacin mesylate in mice, rats, dogs, monkeys, and humans. Antimicrob Agents Chemother 25:463, 1984
Montay G, Jacquot C, Mariety J, Cunci R: Pharmacokinetics of Pefloxacin in renal insufficiency. Eur J Clin Pharmacol 29:345, 1985
Main references
Giudicelli JF, Richer C, Chauvin M, Idrissi N, Berdeaux A: Comparative β-adrenoceptor blocking effects and pharmacokinetics of Penbutolol and propranolol in man. Br J Clin Pharmacol 4:135, 1977
Lehr KH, Damm P, Hajdu P: Direct assay of conjugates of penbutolol and its metabolites in urine. Arzneimittelforschung (Drug Res) 37(11):1373, 1987
Meyer BH, Müller FO, Lötter MG, Iturralde MP, Grigoleit HG: The effect of penbutolol on glomerular filtration. S Afr Med J 60:243, 1981
Pauls A: Vergleichende Untersuchungen zum Eliminationsverhalten einiger Drogen bei Hämodialyse, Hämoperfusion, Hämo-filtrationund Plasmafiltration. Inaugural Dissertation, Free University Berlin (Germany), 1984
Valiner JJ, Jun HW, Needham TE, Stewart JT, Brown W, Frazer H, Honigberg IL: Plasma level studies of penbutolol after oral dose in man. J Clin Pharmacol 17:231, 1977
Main references
Bacon PA, Tribe CR, MacKenzie JC: Penicillamine nephropathy in rheumatoid arthritis. Q J Med 180:661, 1976
Bailey RR, Reddy J: Penicillamine-induced acute renal failure. NZ Med J 93:24, 1981
Bergstom RF, Kay DR, Harkcom TM, Wagner JG: Penicillamine kinetics in normal subjects. Clin Pharmacol Ther 30:404, 1981
Day AT, Golding JR: Hazards of penicillamine therapy in the treatment of rheumatoid arthritis. Postgrad Med J 50 (Suppl 2):71, 1974
Dische FE, Swinson DR, Hamilton EBD, Parsons V: Immunopa-thology of penicillamine-induced glomerular disease. J Rheumatol 11:584, 1984
Feehally J, Wheeler DC, Mackay EH, Oldham R, Walls J: Recurrent acute renal failure with interstitial nephritis due to D-penicillamine. Ren Fail 10:55, 1987
Hall CL, Jawad S, Harrison PR, MacKenzie JC, Bacon PA, Klouda PT, Maclver AG: Natural course of penicillamine nephropathy: A long term study of 33 patients. Br Med J 296:1083, 1988
Hill HFH: Penicillamine in rheumatoid arthritis: Adverse effects. Scand J Rheumatol (Suppl 28):94, 1979
Jaffe IA, Treser G, Suzuki Y, Ehrenreich T: Nephropathy induced by D-penicillamine. Ann Intern Med 69:549, 1968
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:847, penicillamine.
Muijsers AO, van de Stadt RJ, Henrichs AMA, Ament HJW, van der Korst JK: D-penicillamine in patients with rheumatoid arthritis. Serum levels, pharmacokinetic aspects, and correlation with clinical course and side effects. Arthritis Rheum 27:1362, 1984
Matthey F, Perrett D, Greenwood RN, Baker Rl: The use of D-penicillamine in patients with rheumatoid arthritis undergoing hemodialysis. Clin Nephrol 25:268, 1986
Perrett D, Sneddon W, Stephens AD: Studies on D-penicillamine metabolism in cystinuria and rheumatoid arthritis: Isolation of S-methyl-D-penicillamine. Biochem Pharmacol 25:259, 1976
Rehan A, Johnson K: IgM nephropathy associated with penicillamine. Am J Nephrol 6:71, 1986
Review: Penicillamine nephropathy. Br Med J 282:761, 1981
Sadjadi SA, Seelig MS, Berger AR, Milstoc M: Rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis during treatment with high-dosage D-penicillamine. Am J Nephrol 5:212, 1985
Saetre R, Rabenstein DL: Determination of penicillamine in blood and urine by high performance liquid chromatography. Anal Chem 50:276, 1978
Wiesner RH, Dickson ER, Carlson GL, McPhaul LW, Go VL: The pharmacokinetics of D-penicillamine in man. J Rheumatol 7 (Suppl):51, 1981
Main references
Aberle B, Spitzy KH: Distribution and elimination of high doses of sodium penicillin G in peritoneal dialysis. Int J Clin Pharmacol 1:21, 1967
Baldwin DS, Levine BB, McCluskey RT, Gallo GR: Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med 279:1245, 1968
Barza M, Weinstein L: Pharmacokinetics of the penicillins in man. Clin Pharmacokinet 1:297, 1976
Bergan T: Penicillins. Antibiot Chemother 25:1, 1978
Bloomer HA, Barton LJ, Maddock RK: Penicillin-induced encephalopathy in uremic patients. JAMA 200:121, 1967
Brunner FP, Frick PG: Hypokalemia, metabolic alkalosis, and hypernatremia due to ‘massive’ sodium penicillin therapy. Br Med J 1968, 4:550
Bryan CS, Stone WJ: ‘Comparably massive’ penicillin G therapy in renal failure. Ann Intern Med 82:189, 1975
Bulger RJ, Bennet JV, Boen ST: Intraperitoneal administration of broad-spectrum antibiotics in patients with renal failure. JAMA 194:1198, 1965
Giusti DL: A review of the clinical use of antimicrobial agents in patients with renal and hepatic insufficiency. I. The penicillins. Drug Intell Clin Pharm 7:62, 1973
Main references
Goodman and Gilman’s The pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985:1115, chapter 50, Antimicrobial agents by GL Mandell and MA Sande.
Kunin CM, Finland M: Persistence of antibiotics in blood of patients with acute renal failure. III. Penicillin, streptomycin, erythromycin and kanamycin. J Clin Invest 38:1509, 1959
Lee CS, Marbury TC: Drug therapy in patients undergoing haemodialysis. Clinical pharmacokinetic considerations. Clin Pharmacokinet 9:42, 1984
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:131, penicillin G.
Plaut ME, O’Connell CJ, Pabico RC et al.: Penicillin handling in normal and azotemic patients. J Lab Clin Med 74:12, 1969
Schrier RW, Bulger RJ, VanArsdel PP jr: Nephropathy associated with penicillin and homologues. Ann Intern Med 64:116, 1966
Goodman and Gilman’s The pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985:1115, chapter 50, Antimicrobial agents by GL Mandell and MA Sande
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:282, penicillin V
Main references
Davidson IWF, Miller HS jr, DiCarlo F: Absorption, excretion and metabolism of pentaerythritol tetranitrate by humans. J Pharmacol Exp Ther 175:42, 1970
DiCarlo FJ, Hartigan JM jr, Phillips GE: Enzymatic degradation of pentaerythritol tetranitrate by human blood. Proc Soc Exp Biol Med 118:514, 1965
DiCarlo FJ, Coutinho CB, Crew MC: Sites of absorption of pentaerythritol tetranitrate. Arch Int Pharmacodyn Ther 167:163, 1967
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:944, pentagastrin.
Main references
Launoy L, Guillot M, Jonchere H: Etude du stockage et de l’élimination de la pentamidine chez la souries et le rat blanc. Ann Pharm Fr 18:424, 1960
Waalkes TP, Denham C, DeVita VT: Pentamidine: Clinical pharmacologic correlations in man and mice. Clin Pharmacol Ther 11:505, 1969
Walzer PD, Perl DP, Krogstad DJ, Rawson PG, Schultz MG: Pneumocystis carinii pneumonia in the United States. Ann Intern Med 80:83, 1974
Western KA, Perera DR, Schultz MG: Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia. Ann Intern Med 73:695, 1970
Main references
Beckett AH, Taylor JF, Kourounakis P: The absorption, distribution and excretion of pentazocine in man after oral and intravenous administration. J Pharm Pharmacol 22:123, 1970
Berkowitz BA, Asling JH, Shnider SM, Way EL: Relationship of pentazocine plasma levels to pharmacological activity in man. Clin Pharmacol Ther 10:320, 1969
Berkowitz B, Way EL: Metabolism and excretion of pentazocine in man. Clin Pharmacol Ther 10:681, 1969
Brogden RN, Speight TM, Avery GS: Pentazocine: A review of its pharmacological properties, therapeutic efficacy and dependence liability. Drugs 5:6, 1973
Ehrnebo M, Boreus LO, Lonroth U: Bioavailability and first-pass metabolism of oral pentazocine in man. Clin Pharmacol Ther 22:888, 1977
Forrest WH jr: Oral pentazocine. Ann Intern Med 81:644, 1974
Mitchard M: Pharmacokinetic studies on pentazocine. Acta Pharmacol Toxicol (Copenh) 29(Suppl 3): 172, 1971
Mostert JW, Evers JL, Hobika GH, Moore RH, Murphy GP: Circulatory effects of analgesic and neuroleptic drugs in patients with chronic renal failure undergoing maintenance dialysis. Br J Anaesth 42:501, 1970
Payne JP: The clinical pharmacology of pentazocine (Editorial). Drugs 5:1, 1973
Ritschel WA, Hoffmann KA, Willig JL, Frederick KA, Wetzelsberger N: The effect of age on the pharmacokinetics of pentazocine. Methods Find Exp Clin Pharmacol 8:497, 1986
Sigman EM, Elwood CM: Effect of intramuscular pentazocine on renal hemodynamics in normal human subjects. Anesth Analg 46:57, 1967
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:1446, pentetrazol
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:758, pentobarbital
Raventos J: Distribution in body and metabolic fate of barbiturates. J Pharm Pharmacol 6:217, 1954
Reidenberg MM, Lowenthal DT, Briggs W, Gasparo M: Pentobarbital elimination in patients with poor renal function. Clin Pharmacol Ther 20:67, 1976
Main references
Ferrari E, Fioravanti M, Patti AL, Viola C, Solerte SB: Effects of long-term treatment (4 years) with pentoxifylline on hae-morheological changes and vascular complications in diabetic patients. Pharmatherapeutica 5:26, 1987
Hinze HJ, Bedessem G, Söder A: Structure of the excretion products of 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine (BL 191) in man. Arzneimittelforschung (Drug Res) 22:1144, 1972
Hinze HJ, Grigoleit HG, Rethy B: Bioavailability and pharmacokinetics of pentoxifylline from Trental 400 in man. Pharmatherapeutica 1:160, 1976
Lopatkin NA, Ter-Ovanessov GV: The effect of pentoxifylline on oxygen tension in renal tissue: Experimental investigations. Pharmatherapeutica 2 (Suppl 1): 129, 1978
Pilotovich VS et al.: Possiblities of conservative therapy of chronic renal insufficiency. Ter Arkh 54:79, 1982
Pitel JA, Ronkin MA, Solotarjov II, Sereda IV, Volkova VS, Valzeva IA, Zomyk VG: Renal blood flow studies with pentoxifylline. Pharmatherapeutica 2 (Suppl 1):134, 1978
Radmilovic A, Boric Z, Naumovic T, Stamenkovic M, Musikic P: Shunt thrombosis prevention in hemodialysis patients — a double-blind, randomized study: Pentoxifylline vs placebo. Angiology 38:499, 1987
Schaefer K, von Herrath D, Hensel A, Grigoleit HG: Untersuchungen zur Pharmakokinetik von Pentoxifyllin bei chronischer Niereninsuffizienz. Med Klin 72:204, 1977
Ward A, Clissold SP: Pentoxyfylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 34:50, 1987
Main references
Breyer-Pfaff U, Nill K, Schied HW, Gaertner HJ, Giedke H: Single-dose kinetics of the neuroleptic drug perazine in psychotic patients. Psyche-pharmacology (Berlin) 95:374, 1988
Brinkschulte M, Breyer-Pfaff U: Binding of tricyclic antidepressants and perazine to human plasma. Methodology and findings in normals. Naunyn Schmiedebergs Arch Pharmacol 308:1, 1979
Kanig K, Breyer U: Urinary metabolites of 10-(3′-(4′′-Methyl-piperazinyl)-propyl)-phenothiazine (Perazine) in psychiatric patients. II. Individual metabolite patterns and their changes in the course of treatment. Psychopharmacology (Berlin) 14:211, 1969
Krauss D, Otting W, Breyer U: Identification of urinary metabolite perazine as a piperazine-2,5-dione derivate. J Pharm Pharmacol 21:808, 1969
Kress-Hermsdorf M, Forycki Z, Müller-Oerlinghausen B: Experimentelle Untersuchungen zur Hämodialysierbarkeit und Hämoperfundierbarkeit von Perazin. In: Helmchen H, Hippius H, Tolle R (eds): Therapie mit Neuroleptika-Perazin. Stuttgart, New York: Georg Thieme, 1988 p 102
Schley J, Riedel E, Müller-Oerlinghausen B: Stoffwechsel und Ausscheidung des Neuroleptikums Perazin bei gesunden Versuchspersonen. Int Pharmacopsychiatry (Basel) 16:201, 1981
Main references
Feldman G: Hypoglycemie et perhexiline. Nouv Presse Med 3:2580, 1974
Kopelman P, Morgan PGM: Liver damage after perhexiline maleate. Lancet 1:705, 1977
Lhermitte F, Fardeau M, Chedru F, Mallecourt J: Polyneuropathy after perhexiline maleate therapy. Br Med J 1:1256, 1976
Murray W, MacNair DR, Talbot MD: Ataxia during perhexiline maleate therapy. Practitioner 221:757, 1978
Singlas E, Goujet MA, Simon P: Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy. Eur J Clin Pharmacol 14:195, 1978
Stephens WP, Eddy JD, Parsons LM, Singh SP: Raised intracranial pressure due to perhexiline maleate. Br Med J 1:21, 1978
Wright GJ, Leeson GA, Zeiger AV, Lang JF: The absorption, excretion and metabolism of perhexiline maleate by the human. Postgrad Med J 49 (April Suppl):8, 1973
Main references
Lees KR, Green ST, Reid JL: Influence of age on the pharmacokinetics and pharmacodynamics of Perindopril. Clin Pharmacol Ther 44:418, 1988
Lees KR, Hughes DM, McNeil CA, Reid JL: Pharmacokinetics of Perindopril: Therapeutic consequences. Arch Mal Coeur 82 (1):31, 1989
Main references
Gabay S, Huang PC: The binding behavior of phenothiazines and structurally related compounds to albumin from several species. Adv Biochem Psychopharmacol 9:175, 1974
Hansen CE, Christensen TR, Elley J, Hansen LB, Kragh-Sørensen P et al.: Clinical pharmacokinetics studies of perphenazine. Br J Clin Pharmacol 3:915, 1976
Huang CL, Kurland AA: Perphenazine (Trilafon) metabolism in psychotic patients. Arch Gen Psychiatry 10:639, 1964
van Kempen GMJ: Urinary excretion of perphenazine and its sulfoxide during administration in oral and long-acting injectable form. Psychopharmacologia (Berlin) 21:283, 1971
Main references
Edwards DJ, Svensson CK, Visco JP, Lalka D: Clinical pharmacokinetics of pethidine: 1982. Clin Pharmacokinet 7:421, 1982
Klotz U, McHorse TS, Wilkinson GR, Schenker S: The effect of cirrhosis on the disposition and elimination of meperidine in man. Clin Pharmacol Ther 16:667, 1974
Mather LE, Meffin PJ: Clinical pharmacokinetics of pethidine. Clin Pharmacokinet 3:352, 1978
Szeto HH, Inturrisi CE, Houde R, Saal S, Cheigh J, Reidenberg MM: Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure or cancer. Ann Intern Med 86:738, 1977
Verbeeck RK, Branch RA, Wilkinson GR: Meperidine disposition in man: Influence of urinary pH and route of administration. Clin Pharmacol Ther 30:619, 1981
Weir PHC, Chung FF: Anaesthesia for patients with chronic renal disease. Can Anaesth Soc J 31:468, 1984
Main references
Richards RK, Bjornsson TD, Waterbury LD: Rise in serum and urine creatinine after phenacemide. Clin Pharmacol Ther 23:430, 1978
Main references Analgesic nephrophathy and renal carcinoma:
Bengtsson U: A comparative study of chronic non-obstructive pyelonephritis and renal papillary necrosis. Acta Med Scand 172 (Suppl. 388):4, 1962
Bengtsson U, Johansson S, Angervall L: Malignancies of the urinary tract and their relation to analgesic abuse. Kidney Int 13:107, 1978
Durbach VC, Rosner B, Pfister E: Epidemiologic study of abuse of analgesic containing phenacetin. Renal morbidity and mortality (1968–1979). N Engl J Med 308:357, 1983
Grimlund K: Phenacetin and renal damage at a Swedish factory. Acta Med Scand 174 (Suppl. 405): 1, 1963
Hultengren N, Lagergren C, Ljungqvist A: Carcinoma of the renal pelvis in renal papillary necrosis. Acta Chir Scand 130:314, 1965
Kincaid-Smith P: Analgesic abuse and the kidney. Kidney Int 17:250, 1980
Küng LG: Hypernephroides Karzinom und Karzinome der ableitenden Harnwege nach Phenacetinabusus. Schweiz Med Wochenschr 106:47, 1976
Mihatsch MJ, Manz T, Knüsli C, Hofer HO, Rist M, Guetg R, Rutishauser G, Zollinger HU: Phenacetinabusus. III. Maligne Harnwegtumoren bei Phenacetinabusus in Basel 1963–1977. Schweiz Med Wochenschr 110:255, 1980
Piper JM, Tonascia J, Matanoski GM: Heavy phenacetin use and bladder cancer in women aged 20 to 49. N Engl J Med 313:292, 1985
Prescott LF: Analgesic nephropathy: A reassessment of the role of phenacetin and other analgesics. Drugs 23:75, 1982
Scheler F, Schoel G: Analgetikaabusus unter spezieller Berücksichtigung der Analgetika-Nephropathie. Internist 27:770, 1986
Schwarz A: Analgesic-associated nephropathy. Klin Wochenschr 65:1, 1987
Spühler O, Zollinger HU: Die chronisch-interstitielle Nephritis. Z Klin Med 151:1, 1953
Symposium of analgetic nephropathy. Kidney Int 13:1, 1978
Zollinger HU, Spühler O: Die nicht-eitrige, chronische interstitielle Nephritis. Schweiz Z Allg Phatol 13:807, 1950
Main references
Johnson WJ, Chartrand A: The metabolism and excretion of phenazopyridine hydrochloride in animals and man. Toxicol Appl Pharmacol 37:371, 1976
Main references
Cole M, Kenig MD, Hewitt VA: Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption. Antimicrob Agents Chemother 3:463, 1973
Main references
Alkalay D, Khemani L, Wagner WE jr, Bartlett MF: Pharmacokinetics of phenformin in man. J Clin Pharmacol 15:446, 1975
Beckman R: The fate of biguanides in man. Ann NY Acad Sci 148:820, 1968
Milisci RE, Deherd J, McFadden ER, Strader WJ, Nusynowitz ML: Phenformin-induced lactic acidosis. Am J Med Sci 265:447, 1973
Nattrass M, Sizer K, Aalberti KGMM: Correlation of plasma phenformin concentration with metabolic effects in normal subjects. Clin Sci 58:153, 1980
Main references
Kabasakalian P, Taggart M, Townley E: Urinary excretion of pheniramine and its N-demethylated metabolites in man — comparison with chlorpheniramine and brompheniramine data. J Pharm Sci 57:621, 1968
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:458, pheniramine aminosalicylate.
Main references
Brown SR, Hartshorn EA: Interactions of CNS drugs — hypnotics and sedatives. Drug Intell Clin Pharm 10:570, 1976
Lous P: Plasma levels and urinary excretion of 3 barbituric acids after oral administration in man. Acta Pharmacol Toxicol (Copenh) 10:147, 1954
Lous P: Barbituric acid concentration in serum from patients with severe poisoning. Acta Pharmacol Toxicol (Copenh) 10:261, 1954
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 404, phenobarbital.
Pierides AM, Ellis HA, Ward M, Simpson W, Peart KM, Alvarez-Ude F, Uldall PR, Kerr DNS: Barbiturate and anticonvulsant treatment in relation to osteomalacia with haemodialysis and renal transplantation. Br Med J 1:190, 1976
Pond S, Rosenberg J, Benowitz NL, Takki S: Pharmacokinetics of haemoperfusion for drug overdose. Clin Pharmacokinet 4:329, 1979
Waddell WJ, Butler TC: The distribution and excretion of phenobarbital. J Clin Invest 36:1217, 1957
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:967, phenol.
Main references
Council of Drugs: Phenoxybenzamine hydrochloride. JAMA 164:1756, 1957
Goodman and Gilman’s The pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985: 181, chapter 9, Drugs that inhibit adrenergic nerves and block adrenergic receptors by N Weiner.
Main references
Albert FW: In: Marx R, Thies HA (eds): Niere, Blutgerinnung und Hämostase. Stuttgart, New York: Schattauer, 1978 p 333
Held H, Baetzner P, Liebau G, Bundschu HD, Hayduk K: Besonderheiten bei der Behandlung von Dialysepatienten mit Phenprocoumon (Marcumar). Verh Dtsch Ges Inn Med 81:1013, 1975
Hewick DS, Shepherd AMM: The plasma elimination of the enantiomers of phenprocoumon in man. J Pharm Pharmacol 28:257, 1976
Köstering H, Walther C, Quellhorst E, Wigger W, Scheler F: Antikoagulationsbehandlung zur Vermeidung von Shuntthrombosierungen bei Hämodialysepatienten. Med Klin 65:2012, 1970
Main references
Bratschi HU: Pharmakokinetische Untersuchungen mit oral verabreichtem Phentolamin. Inaugural Dissertation, University Bern (Switzerland), 1981
Goodman and Gilman’s The pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985:181, chapter 9, Drugs that inhibit adrenergic nerves and block adrenergic receptors by N Weiner.
Gross F, Tripod J, Meier R: Regitin (Präparat C 7337), ein neues Imidazolinderivat mit spezifischer sympathikolytischer Wirkung. Schweiz Med Wochenschr 81:352, 1951
Gould L, Ramana Reddy CV: Phentolamine. Am Heart J 92:397, 1976
Henquet JW. Rahn KH: Die medikamentöse Therapie der Hypertonie. Innere Med 4:372, 1977
Imhof PR, Garnier B, Brunner L, Keller G, Rohrer T: Human pharmacology of orally administered phentolamine. In: Taylor SH, Gould LA (eds): Phentolamine in heart failure and other cardiac disorders. Bern, Stuttgart, Wien: Hans Huber, 1976 p 11–22
Kötter V, von Leitner ER, Wunderlich J, Schröder R: Comparison of haemodynamic effects of phentolamine, sodium nitroprusside, and glyceryl trinitrate in acute myocardial infarction. Br Heart J 39:1196, 1977
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:494, phentolamine hydrochloride
Motin J, Petit P, Bouletreau P, Latarjet J: Etude hemodinamique du choc septique, à propos de 26 observations. Nouv Presse Med 3:1481, 1974
Pfister B, Imhof PR: Estimation of the plasma concentration and course of action of phentolamine based on its inhibitory effect on adrenaline-induced platelet aggregation. Br J Clin Pharmacol 5:175, 1978
Schröder R: Behandlung der Herzinsuffizienz mit Vasodilatoren. Dtsch Med Wochenschr 102:1388, 1977
Main references General:
Aarbakke J, Bakke OM, Milde EJ, Davies DS: Disposition and oxidative metabolism of phenylbutazone in man. Eur J Clin Pharmacol 11:359, 1977
Aarbakke J: Clinical pharmacokinetics of phenylbutazone. Clin Pharmacokinet 3:369, 1978
Dieterle W, Faigle JW, Früh F, Mory H, Theobald W, Alt KO, Richter WJ: Metabolism of phenylbutazone in man. Arzneimittelforschung (Drug Res) 26:572, 1976
Held H, Enderle C: Elimination and serum protein binding of phenylbutazone in patients with renal insufficiency. Clin Nephrol 6:388, 1976
Prescott LF, Critchley JAJH, Balali-Mood M: Phenylbutazone overdosage: Abnormal metabolism associated with hepatic and renal damage. Br Med J 2:1106, 1982
Richardson JH, Alderfer HH: Acuta renal failure caused by phenylbutazone. N Engl J Med 268:809, 1969
Scheitlin W, Jeanneret P: Über akute Nierenschädigungen unter Phenylbutazontherapie. Schweiz Med Wochenschr 87:881, 1957
Triggs EJ, Nation RL, Long A, Aschley JJ: Pharmacokinetics in the elderly. Eur J Clin Pharmacol 8:55, 1975
Renal damage:
Abraham PA, Keane WF: Glomerular and interstitial disease induced by nonsteroidal anti-inflammatory drugs. Am J Nephrol 4:1, 1984
Carmichael J, Shankel SW: Effects of non-steroidal anti-inflammatory drugs on prostaglandins and renal function. Am J Med 78:992, 1985
Clive DM, Stoff JS: Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N Engl J Med 310:563, 1984
Duggin GG: Mechanisms in the development of analgesic nephropathy. Kidney Int 18:553, 1980
Dunn MJ: Non-steroidal anti-inflammatory drugs and renal function. Annu Rev Med 35:411, 1984
Hart D, Lifschitz MD: Renal physiology of the prostaglandins and the effects of nonsteroidal anti-inflammatory agents on the kidney. Am J Nephrol 7:408, 1987
Henrich WL: Nephrotoxicity of nonsteroidal anti-inflammatory agents. Am J Kidney Dis 2:478, 1982
Orme ML’E: Non-steroidal anti-inflammatory drugs and the kidney. Br Med J 292:1521, 1986
Reeves WB, Foley RJ, Weinman EJ: Renal dysfunction from nonsteroidal anti-inflammatory drugs. Arch Intern Med 144:1943, 1984
Simon LS, Mills JA: Nonsteroidal antiinflammatory drugs (First of two parts). N Engl J Med 302:1179, 1980
Simon LS, Mills JA: Nonsteroidal antiinflammatory drugs (Second of two parts). N Engl J Med 302:1237, 1980
Torres VE: Present and future of non-steroidal anti-inflammatory drugs in nephrology. Mayo Clin Proc 57:389, 1982
Toto RD, Anderson SA, Brown-Cartwright D, Kokko JP, Brater DG: Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency. Kidney Int 30:760, 1986
Wegmüller E: Nicht-steroidale Antirheumatika und Nephrotoxi-zität. Dtsch Med Wochenschr 110:469, 1985
Main references
Hengstmann JH, Goronzy J: Pharmacokinetics of 3H-phenylephrine in man. Eur J Clin Pharmacol 21:335, 1982
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:1473, phenylephrine hydrochloride
Meyer SM, Fraunfelder FT: 3. Phenylephrine hydrochloride. Ophthalmology 87:1177, 1980
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 1475, phenylpropanolamine hydrochloride
Main references
Adler DS: Phenytoin. J Toxicol Clin Toxicol 14:147, 1979
Agarwal BN, Cabebe FG, Hoffman BI: Diphenylhydantoin-induced acute renal failure. Nephron 18:249, 1977
Blum MR, Riegelman S, Becker CE: Altered protein binding of diphenylhydantoin in uremic plasma. N Engl J Med 286:109, 1972
Borga O, Hoppel C, Odar-Cederlöf I, Garle M: Plasma levels and renal excretion of phenytoin and its metabolites in patients with renal failure. Clin Pharmacol Ther 26:306, 1979
Glazko AJ: Diphenylhydantoin metabolism. Drug Metab Dispos 5:711, 1973
Kinniburgh WD, Boyd ND: Phenytoin binding to partially purified albumin in renal disease. Clin Pharmacol Ther 29:203, 1981
Martin E, Gambertoglio JG, Adler DS, Tozer TN, Roman LA, Gransz H: Removal of phenytoin by hemodialysis in uremic patients. JAMA 238:1750, 1977
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:406, phenytoin
Odar-Cederlöf I, Borga O: Kinetics of diphenylhydantoin in uremic patients: Consequences of decreased plasma protein binding. Eur J Clin Pharmacol 7:31, 1974
Odar-Cederlöf I, Borga O: Lack of relationship between serum free fatty acids and impaired plasma protein binding of diphenylhydantoin in chronic renal failure. Eur J Clin Pharmacol 10:403, 1976
Reidenberg MM, Odar-Cederlöf I, von Bahr C, Borga O, Sjöqvist F: Protein binding of diphenylhydantoin and desmethylimi-pramine in plasma from patients with poor renal function. N Engl J Med 285:264, 1971
Richens A: Clinical pharmacokinetics of phenytoin. Clin Pharmacokinet 4:153, 1979
Steele WH, Lawrence JR, Elliott HL, Whiting B: Alteration of phenytoin protein binding with in vivo haemodialysis in dialysis encephalopathy. Eur J Clin Pharmacol 15:69, 1979
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:284, phthalylsulphathiazole
Main references
Daunderer M: Physostigmine salicylate as an antidote. Int J Clin Pharmacol Ther Toxicol 18:523, 1980
Goodman and Gilman’s The pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985:110, chapter 6, anticholinestrase agents by P Taylor
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:1333, physostigmine
Main references
Choonara IA, Scott AK, Haynes BP, Cholerton S, Breckenridge AM, Park BK: Vitamin K1 metabolism in relation to pharmacodynamic response in anticoagulated patients. Br J Clin Pharmacol 20:643, 1985
Stone WJ: Vitamin supplementation of hemodialysis patients. Dial Transplant 6:51, 1977
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:1335, pilocarpine
Mishima S: Clinical pharmacokinetics of the eye. Proctor lecture. Invest Ophthalmol Vis Sci 21:504, 1981
Main references
Chau NP, Weiss YA, Safar ME, Lavene DE, Georges DR, Milliez PL: Pindolol availability in hypertensive patients with normal and impaired renal function. Clin Pharmacol Ther 22:505, 1977
Galeazzi RL, Gugger M, Weidmann P: Beta blockade with pindolol: Differential cardiac and renal effects despite similar plasma kinetics in normal and uremic man. Kidney Int 15:661, 1979
Glassock RJ, Weitzman RE, Bennett CM, Maxwell M, Hamilton B, Winer N, Kirkendall W, Gonasun L: Pindolol: Effects on blood pressure and plasma renin activity. Am Heart J 104:421, 1982
Gugler R, Herold W, Dengler HJ: Pharmacokinetics of pindolol in man. Eur J Clin Pharmacol 7:17, 1974
Heierli C, Thoelen H, Radielovic P: Renal function following a single dose of pindolol in hypertensive patients with varying degrees of impairment of renal function. Int J Clin Pharmacol 15:65, 1977
Herb HM, Heinze V: Wirkdauer von Pindolol bei chronischen Urämikern. Klin Wochenschr 57:851, 1979
Lavene D, Weiss YA, Safar ME, Loria Y, Agorus N, Georges D, Milliez PL: Pharmacokinetics and hepatic extraction ratio of pindolol in hypertensive patients with normal and impaired renal function. J Clin Pharmacol 17:501, 1977
Meier J: Pindolol: A pharmacokinetic comparison with other beta-adrenoceptor blocking agents. Curr Med Res Opin 4 (Suppl 5):31, 1977
Oie S, Levy G: Relationship between renal function and elimination kinetics of pindolol in man. Eur J Clin Pharmacol 9:115, 1975
Ohnhaus EE, Heidemann H, Meier J, Maurer G: Metabolism of pindolol in patients with renal failure. Eur J Clin Pharmacol 22:423, 1982
Safar ME, Chau NP, Levenson JA, Simon AC, Weiss YA: Pharmacokinetics of intravenous and oral pindolol in hypertensive patients with chronic renal failure. Clin Sci Mol Med 55:275S, 1978
Wainer E, Boner G, Rosenfeld JB: Effects of pindolol on renal function. Clin Pharmacol Ther 28:575, 1980
Main references
Brogard JM, Comte F, Lavillaureix J: Comparative pharmacokinetic profiles of Cinoxacin and pipemidic acid in humans. Eur J Drug Metab Pharmacokinet 8:251. 1983
Klinge E, Männistö PT, Mäntylä R, Mattila J, Hänninen U: Single-and multiple-dose pharmacokinetics of pipemedic acid in normal human volunteers. Antimicrob Agents Chemother 26:69, 1984
Kurobe N, Nakamura S, Shimizu M: Metabolites of pipemidic acid in human urine. Xenobiotica 10:37, 1980
Main references
Aronoff GR, Sloan RS, Brier ME, Luft FC: The effect of piperacillin dose on elimination kinetics in renal impairment. Eur J Clin Pharmacol 24:543, 1983
Francke EL, Appel GB, Neu HC: Pharmacokinetics of intravenous piperacillin in patients undergoing chronic hemodialysis. Antimicrob Agents Chemother 16:788, 1979
Giron JA, Meyers BR, Hirschman SZ, Srulevitch E: Pharmacokinetics of piperacillin in patients with moderate renal failure and in patients undergoing hemodialysis. Antimicrob Agents Chemother 19:279, 1981
Heim-Duthoy KL, Halstenson CE, Abraham PA, Matzke GR: The effect of hemodialysis on piperacillin pharmacokinetics. Int J Clin Pharmacol Ther Toxicol 24:680, 1986
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:285, piperacillin sodium
Tartaglione TA, Nye L, Vishniavsky N, Poynor W, Polk RE: Multiple-dose pharmacokinetics of piperacillin and azlocillin in 12 healthy volunteers. Clin Pharm 5:911, 1986
Welling PG, Craig WA, Bundtzen RW et al.: Pharmacokinetics of piperacillin in subjects with various degrees of renal function. Antimicrob Agents Chemother 23:881, 1983
Main references
Fletcher KA, Evans DAP, Kelly JA: Urinary piperazine excretion in healthy Caucasians. Ann Trop Med Parasitol 76:77, 1982
Fuhrmann G: Zur Frage der Resorption und Ausscheidung von Piperazinsalzen. Z Tropenmed Parasitol 8:83, 1957
Graf W, Haldimann B, Flury W: Piperazinintoxikation bei Lang-zeithämodialyse. Schweiz Med Wochenschr 108:177, 1978
Hanna S, Tang A: Human urinary excretion of piperazine citrate from syrup formulations. J Pharm Sci 62:2024, 1973
Harned BK, Cunningham RW, Halliday S, Vessey RE, Yuda NN, Clark MC, Hine CH, Cosgrove R, Subbarow Y: Studies on the chemotherapy of filariasis VI. Some pharmacodynamic properties of 1-diethylcarbamyl-4-methylpiperazine hydrochloride, hetrazan. J Lab Clin Med 33:216, 1948
Mössmer A: Über Wirksamkeit, Dosierung und Vergiftungserscheinungen von Piperazin-Präparaten. Med Monatsschr 10:517, 1956
Oelkers HA: Beitrag zur Pharmakologie des Piperazins. Ärztl Forsch 19:625, 1965
Main references
Gladigau V, Ehret I: Metabolismus und Pharmakokinetik von Piprozolin bei Ratte, Hund und Mensch. 3. Mitteilung: Bestimmung von Piprozolin und Metabolit I in Plasma und Urin. Arzneimittelforschung (Drug Res) 27(I):512, 1977
Hodenberg A von, Kiemisch W, Vollmer KO: Metabolismus und Pharmakokinetik von Piprozolin bei Ratte, Hund und Mensch. 2. Mitteilung: Erstellung von Metabolitenprofilen mit Hilfe der Koppung H PLC-Radioaktivitätsdetektor nach direkter Injektion von Urin und Galle auf eine Reversed-Phase-Säule. Arzneimittelforschung (Drug Res) 27(I):508, 1977
Schleicher E: Piprozolin in der klinischen Prüfung. Arzneimittelforschung (Drug Res) 27(I):520, 1977
Vollmer KO, von Hodenberg A, Poisson A, Bode R, Schauerte E: Metabolismus und Pharmakokinetik von Piprozolin bei Ratte, Hund und Mensch. 1. Mitteilung: Untersuchungen mit radioaktiv markierter Substanz. Arzneimittelforschung (Drug Res) 27(I):502, 1977
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:1602, piracetam.
Main references
Eberlein W, Schmidt G, Reuter A, Kutter E: Das Ulkustherapeutikum Pirenzepin (L-S 519) — eine tricyclische Verbinding mit besonderen physikalisch-chemischen Eigenschaften. Arzneimittelforschung (Drug Res) 27(I):356, 1977
Hammer R, Bozler G, Zimmer A, Koss FW, Hadamovsky S, Kompa H: Pharmakokinetik und Metabolismus von LS 519-Cl2 (Pirenzepin*) beim Menschen. Therapiewoche 27:1575, 1977
Krakamp B, Leidig P, Tanswell P, Schmitz R, Bozler G: Pharmacokinetics of pirenzepine in hepatic insufficiency and combined renal-hepatic insufficiency. Dig Dis Sci 31 (Suppl 10):391S, 1986
Main references
Brater DC, Anderson S, Baird B, Kaojarern S: Effects of piret-anide in normal subjects. Clin Pharmacol Ther 34:324, 1983
Brazier JL, Pozet N, Faucon G, Traeger J, Hajd-Haissa A: Kinetics of a high dose of piretanide in renal failure. Eur J Clin Pharmacol 21:307, 1982
Bricker NS: Sodium homeostasis in chronic renal disease. Kidney Int 21:868, 1982
Clissold SP, Brogden RN: Piretanide. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 29:489, 1985
Gerber JG: Antihypertensive agents and diuretics. In: Anderson RJ, Schrier RW (eds), Clinical use of drugs in patients with kidney and liver disease, London: Saunders, 1981 p 211–29
Marone C, Reubi FC, Lahn W: Comparison of the short-term effects of the loop diuretic piretanide and furosemide in patients with renal insufficiency. Eur J Clin Pharmacol 26:413, 1984
Marone C, Reubi FC, Perisic M, Lahn W: Pharmacokinetics of high doses of piretanide in moderate to severe renal failure. Eur J Clin Pharmacol 27:589, 1984
Trenk D, Wagner F, Jähnchen E, Spahn H, Mutschier E: Pharmacokinetics and bioavailability of piretanide in healthy volunteers following intramuscular administration. Arzneimittelforschung (Drug Res) 37(II): 1382, 1987
Walter U, Röckel A, Lahn W, Heidland A, Heptner W: Pharmacokinetics of the loop diuretic pirenatide in renal failure. Eur J Clin Pharmacol 29:337, 1985
Main references
Janssen PAJ: Pirinitramide (R 3365), a potent analgesic with unusual chemical structure. J Pharm Pharmacol 13:513, 1961
Janssen PAJ, Allewijn FTN: The distribution of the butyrophe-nones haloperidol, trifluperidol, moperone, and clofluperol in rats, and its relationship with their neuroleptic activity; Arz-neimittelforschung (Drug Res) 19:199, 1969
Lewi PJ, Chandler AEF, VanRiel DG, Somers PJ, Allewijn FTN, Dony JGH, Janssen PAJ: Computer procedures for evaluating the results of studies on the distribution and metabolism of drugs in the body. Arzneimittelforschung (Drug Res) 20:684, 1970
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:288, piromidic acid.
Shimizu M, Nakamura S, Takasa Y: Piromidic acid, a new antibacterial agent: Antibacerial properties. Antimicrob Agents Chemother 1970, p. 117
Shimizu M, Sekine Y, Higuchi H, Suzuki H, Nakamura S, Nakamura K: Piromidic acid, a new antibacterial agent: Absorption, distribution, excretion, and metabolism. Antimicrob Agents Chemother 1970, p. 123
Main references General:
Brogden RN, Heel RC, Speight TM, Avery GS: Piroxicam: A reappraisal of its pharmacology and therapeutic efficacy. Drugs 28:292, 1984
Dupont D, Dayer P, Balant L, Gorgia A, Fabre J: Variations interet intraindividuelles du comportement du Piroxicam. Pharma-cocinétique chez l’homme en bonne santé et chez le malade en insuffisance renale. Pharm Acta Helv 57:20, 1982
Hobbs DC: Piroxicam pharmacokinetics: Recent clinical results relating kinetics and plasma levels to age, sex, and adverse effects. Am J Med 81 (Suppl 5B):22, 1986
Ishizaki T, Nomura T, Abe T: Pharmacokinetics of Piroxicam, a new nonsteroidal anti-inflammatory agent, under fasting and postprandial states in man. J Pharmacokinet Biopharm 7:369, 1979
Milani L, Macca F, Bazzerla G, Da Ros I, Merlo A, Zeni G, Gatta A: Investigation of a new non-steroidal anti-inflammatory drug, Piroxicam, for renal tubular effects. Curr Ther Res 34:940, 1983
Pitts NE: Efficacy and safety of Piroxicam. A review of Piroxicam. Am J Med 72 (Suppl Febr 16): 77, 1982
Rogers HJ, Spector RG, Morrison PJ, Bradbrook ID: Comparative steady state pharmacokinetic study of Piroxicam and flurbiprofen in normal subjects. Eur J Rheum Inflamm 4:303, 1981
Wiseman EH, Hobbs DC: Review of pharmacokinetic studies with Piroxicam. A review of Piroxicam. Am J Med 72 (Suppl Febr 16): 9, 1982
Woolf AD, Rogers HJ, Bradbrook ID, Corless D: Pharmacokinetic observations on Piroxicam in young adult, middle-aged and elderly patients. Br J Clin Pharmacol 16:433, 1983
Renal damage:
Abraham PA, Keane WF: Glomerular and interstitial disease induced by nonsteroidal anti-inflammatory drugs. Am J Nephrol 4:1, 1984
Carmichael J, Shankel SW: Effects of non-steroidal anti-inflammatory drugs on prostaglandins and renal function. Am J Med 78:992, 1985
Clive DM, Stoff JS: Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N Engl J Med 310:563, 1984
Duggin GG: Mechanisms in the development of analgesic nephropathy. Kidney Int 18:553, 1980
Dunn MJ: Non-steroidal anti-inflammatory drugs and renal function. Annu Rev Med 35:411, 1984
Hart D, Lifschitz MD: Renal physiology of the prostaglandins and the effects of nonsteroidal anti-inflammatory agents on the kidney. Am J Nephrol 7:408, 1987
Henrich WL: Nephrotoxicity of nonsteroidal anti-inflammatory agents. Am J Kidney Dis 2:478, 1982
Orme ML’E: Non-steroidal anti-inflammatory drugs and the kidney. Br Med J 292:1521, 1986
Reeves WB, Foley RJ, Weinman EJ: Renal dysfunction from nonsteroidal anti-inflammatory drugs. Arch Intern Med 144:1943, 1984
Simon LS, Mills JA: Nonsteroidal antiinflammatory drugs (First of two parts). N Engl J Med 302:1179, 1980
Simon LS, Mills JA: Nonsteroidal antiinflammatory drugs (Second of two parts). N Engl J Med 302:1237, 1980
Torres VE: Present and future of non-steroidal anti-inflammatory drugs in nephrology. Mayo Clin Proc 57:389, 1982
Toto RD, Anderson SA, Brown-Cartwright D, Kokko JP, Brater DG: Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency. Kidney Int 30:760, 1986
Wegmüller E: Nicht-steroidale Antirheumatika und Nephrotoxi-zität. Dtsch Med Wochenschr 110:469, 1985
Main references General:
Dionne RE, Weber SS: Pirprofen. Drug Intell Clin Pharm 17:894, 1983
Luders RC, Maggio-Cavaliere MB, Egger H, Gum OB, Resnick O, Bartlett MF, Gaito ME, Soo A, Li C: Disposition of pirprofen, a new anti-inflammatory drug. Clin Pharmacol Ther 21:721, 1977
Renal damage:
Abraham PA, Keane WF: Glomerular and interstitial disease induced by nonsteroidal anti-inflammatory drugs. Am J Nephrol 4:1, 1984
Carmichael J, Shankel SW: Effects of non-steroidal anti-inflammatory drugs on prostaglandins and renal function. Am J Med 78:992, 1985
Clive DM, Stoff JS: Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N Engl J Med 310:563, 1984
Duggin GG: Mechanisms in the development of analgesic nephropathy. Kidney Int 18:553, 1980
Dunn MJ: Non-steroidal anti-inflammatory drugs and renal function. Annu Rev Med 35:411, 1984
Hart D, Lifschitz MD: Renal physiology of the prostaglandins and the effects of nonsteroidal anti-inflammatory agents on the kidney. Am J Nephrol 7:408, 1987
Henrich WL: Nephrotoxicity of nonsteroidal anti-inflammatory agents. Am J Kidney Dis 2:478, 1982
Orme ML’E: Non-steroidal anti-inflammatory drugs and the kidney. Br Med J 292:1521, 1986
Reeves WB, Foley RJ, Weinman EJ: Renal dysfunction from nonsteroidal anti-inflammatory drugs. Arch Intern Med 144:1943, 1984
Simon LS, Mills JA: Nonsteroidal antiinflammatory drugs (First of two parts). N Engl J Med 302:1179, 1980
Simon LS, Mills JA: Nonsteroidal antiinflammatory drugs (Second of two parts). N Engl J Med 302:1237, 1980
Torres VE: Present and future of non-steroidal anti-inflammatory drugs in nephrology. Mayo Clin Proc 57:389, 1982
Toto RD, Anderson SA, Brown-Cartwright D, Kokko JP, Brater DG: Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency. Kidney Int 30:760, 1986
Wegmüller E: Nicht-steroidale Antirheumatika und Nephrotoxi-zität. Dtsch Med Wochenschr 110:469, 1985
Main reference
Meier J: Sandoz publication: BC 105 (Sandomigrin), Basle, Sept. 1974
Main reference
Reuter HJ: Die Verödung von Nierenzysten. Aktuelle Urol 18:25, 1987
Main references
Goodman and Gilman’s The pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985:1170, chapter 52, Antimicrobial agents by MA Sande and GL Mandell
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:290, polymyxin B sulfate
Main references
Bricker NS: Sodium homeostasis in chronic renal disease. Kidney Int 21:868, 1982
Dreifus LS, Duarte CG, Kodama R, Mover HJ: The effect of thiazide diuretics on the abnormal kidney. Ann Intern Med 53:1170, 1960
Gerber JG: Antihypertensive agents and diuretics. In: Anderson RJ, Schrier RW (eds). Clinical use of drugs in patients with kidney and liver disease, London: Saunders, 1981 p 211–29
Main reference
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:798, practolol.
Main reference
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:850, pralidoxime chloride.
Main references
Ochs HR, Greenblatt DJ, Verburg-Ochs B, Locniskar A: Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: Three precursors of desmethyldiazepam. J Clin Pharmacol 24:446, 1984
Smith MT, Evans LEJ, Eadie MJ, Tyrer JH: Pharmacokinetics of prazepam in man. Eur J Clin Pharmacol 16:141, 1979
Main references
Andrews P, Thomas H, Pohlke R, Seubert J: Praziquantel. Med Res Rev 3:147, 1983
Chen M, Fu S, Hua X, Wu H: A retrospective survey on side effects of praziquantel among 25,693 cases of schistosomiasis japonica. Southeast Asian J Trop Med Public Health 14:495, 1983
Farid Z, Ayad El-Masry N, Bassily S, Trabolsi B: Treatment of bilharzial obstructive uropathy with praziquantel. J Infect Dis 150:307, 1984
Frohberg H: Pharmacokinetical, pharmacological and toxicological properties of praziquantel. Salud Publica Mex 24:605, 1982
Gordillo-Paniagua G, Munoz-Arizpe R, Ponsa-Molina R: Unusual complication in a patient with renal transplantation: Cerebral cysticercosis. Nephron 45:65, 1987
Hefty TR, McCorkell SJ: Schistosomiasis and renal transplantation. J Urol 135:1163, 1986
Leopold G, Diekmann H, Nowak H, Patzschke K: Pharmacokinetics of praziquantel. Tropenmed Parasit 28:276, 1977
Massoud A, Hafez AS, Hussein MM, Abdel Karim AH, El Nahaal A: Pharmacokinetic studies on praziquantel and oxamniquine in intestinal schistosomiasis. J Egypt Soc Parasitol 14:599, 1984
Papadopoulos I, Ebert W: Urogenital schistosomiasis in Germany. Dtsch Med Wochenschr 109:136, 1984
Patzschke K, Pütter J, Wegner LA, Hörster FA, Diekmann HW: Serum concentrations and renal excretion in humans after oral administration of praziquantel — results of three determination methods. Eur J Drug Metab Pharmacokinet 4:149, 1979
Pehrson PO, Bengtsson E, Diekmann HW, Groll E: Treatment with praziquantel in a patient with schistosomiasis and chronic renal failure. Trans Roy Soc Trop Med Hyg 77:687, 1983
Steiner K, Garbe A, Diekmann HW, Nowak H: The fate of praziquantel in the organism. I. Pharmacokinetics in animal. Eur J Drug Metab Pharmacokinet 1:85, 1976
Main references
Baciarello G, Di Maio F, Russo GE, Villatico Campbell S: Efficacy of prazosin in therapy of arterial hypertension of chronic uraemic patients undergoing dialysis treatment: 6-month follow-up. Curr Ther Res 28:326, 1980
Bailey RR, Lynn KL, Neale TL, Little PJ: Prazosin in the treatment of patients with hypertension and renal functional impairment. NZ Med J 84:467, 1976
Chaignon M, Le Roux E, Aubert P, Lucsko M, Safar M, Flouvat B, Guedon J: Clinical pharmacology of prazosin in hypertensive patients with chronic renal failure. J Cardiovasc Pharmacol 3:151, 1981
Curtis JR, Bateman FJA: Use of prazosin in management of hypertension in patients with chronic renal failure and in renal transplant recipients. Br Med J 1975, 4:432
Graham RM, Pettinger WA: Drug therapy: Prazosin. N Engl J Med 300:232, 1979
Grahnén A, Seideman P, Lindström B, Haglund K, von Bahr C: Prazosin kinetics in hypertension. Clin Pharmacol Ther 30:439, 1981
Hobbs DC, Twomey TM, Palmer RG: Pharmacokinetics of prazosin in man. J Clin Pharmacol 18:402, 1978
Hobbs DC, Twomey TM: Protein binding properties of prazosin. Res Commun Chem Pathol Pharmacol 25:189, 1979
Jaillon P: Clinical pharmacokinetics of prazosin. Clin Pharmacokinet 5:365, 1980
Lowenthal DT, Hobbs D, Affrime MB et al.: Prazosin kinetics and effectiveness in renal failure. Clin Pharmacol Ther 27:779, 1980
Stanaszek WF, Kellerman D, Brogden RN, Romankiewicz JA: Prazosin update. A review of its pharmacological properties and therapeutic use in hypertension and congestive heart failure. Drugs 25:339, 1983
Taylor JA, Twomey TM, Schach von Wittenau M: The metabolic fate of prazosin. Xenobiotica 7:357, 1977
Vincent J, Meredith PA, Reid JL, Elliot HL, Rubin PC: Clinical pharmacokinetics of prazosin — 1985. Clin Pharmacokinet 10:144, 1985
Main references
Bergrem H: Pharmacokinetics and protein binding of prednisolone in patients with nephrotic syndrome and patients undergoing hemodialysis. Kidney Int 23:876, 1983
Björck S, Ahlmen J, Mellstrand T, Stelin G: Influence of dialysis on prednisolone kinetics. Acta Med Scand 215:379, 1984
Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJC: Nonlinear plasma protein binding and haemodialysis clearance of prednisolone. Eur J Clin Pharmacol 23:65, 1982
Frey FJ, Frey BM: Altered prednisolone kinetics in patients with the nephrotic syndrome. Nephron, 32:45, 1982
Pickup ME: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet 4:111, 1979
Main reference
Pickup ME: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet 4:111, 1979
Main references
Dengler HJ, Eichelbaum M: Untersuchungen zum verhalten von C14-d,l-Prenylamin im Organismus. Naunyn Schmiedebergs Arch Pharmacol 260:105, 1968
Eichelbaum M, Schomerus M, Dengler HJ: Zur Pharmakokinetik von Prenylamin (Segontin) beim Menschen. Verh Dtsch Ges Inn Med 76:942, 1970
Volz M: Die Biotransformation von Prenylamin im Organismus der Ratte. Arzneimittelforschung (Drug Res) 21:1320, 1971
Main reference
Tucker GT, Mather LE: Properties absorption, and disposition of local anesthetic agents. In: Cousins MJ (ed): Neural blockade in clinical anesthesia and management of pain, 2nd ed. Philadelphia: JB Lippincott Co. 1988, p 47
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:514, primaquine phosphate
Mihaly GW, Ward SA, Edwards G, Nicholl DD, Orme ML, Breck-enridge AM: Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size. Br J Clin Pharmacol 19:745, 1985
Parkhurst GW, Nora MV, Thomas RW, Carson PE: High-performance liquid chromatographic-ultraviolet determination of primaquine and its metabolites in human plasma and urine. J Pharm Sci 73:1329, 1984
Main references
Baumel IP, Gallagher PP, Mattson RH: Phenylethylmalonamide (PEMA). An important metabolite of primidone. Arch Neurol 27:34, 1972
Baumel IP, Gallagher BB, Dimicco J, Goico H: Metabolism and anticonvulsant properties of primidone in the rat. J Pharmacol Exp Ther 186:305, 1973
Booker HE, Hosokowa K, Burdette RD, Darcey B: A clinical study of serum primidone levels. Epilepsia 11:395, 1970
Gallagher BB, Baumel IP, Mattson RH: Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration. Neurology 22:1186, 1972
Lee CSC, Marbury TC, Perchalski RT, Wilder BJ: Pharmacokinetics of primidone elimination by uremic patients. J Clin Pharmacol 22:301, 1982
Schottelius DD: Primidone. Absorption, distribution, and excretion. In: Woodbury DM, Penny JK, Pippenger CE (eds): Anti-epileptic drugs. New York: Raven Press, 1982 p 405–13
Schottelius DD: Primidone. Biotransformation. In: Woodbury DM, Penny JK, Pippenger CE (eds): Antiepileptic drugs. New York: Raven Press, 1982 p 415–19
Main references
Cunningham RF, Israili ZH, Dayton PG: Clinical pharmacokinetics of probenecid. Clin Pharmacokinet 6:135, 1981
Dayton PG, Yü TF, Chen W, Berger L, West LA, Gutman AB: The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material. J Pharmacol Exp Ther 140:278, 1963
Goodman and Gilman’s The Pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985:920, chapter 38, Inhibitors of tubular transport of organic compounds by IM Weiner and GH Mudge
Israili ZH, Perel JM, Cunningham RF, Dayton PG, Yü TF, Gutman AB, Long KR, Long RC jr, Goldstein JH: Metabolites of probenecid. Chemical, physical, and pharmacological studies. J Med Chem 15:709, 1972
Melethil S, Conway WD: Urinary excretion of probenecid and its metabolites in humans as a function of dose. J Pharm Sci 65:861, 1976
Perel JM, Cunningham RF, Fales HM, Dayton PG: Identification and renal excretion of probenecid metabolites in man. Life Sci 9 (Part I): 1337, 1970
Main references
Grützmacher P: unpublished data, 1987
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:1203, probucol
Main references
Atkinson AJ jr, Krumlovsky FA, Huang GM, del Greco F: Hemodialysis for severe procainamide toxicity: Clinical and pharmacokinetic observations. Clin Pharmacol Ther 20:585, 1976
Atkinson AJ jr, Ruo TI: Pharmacokinetics of N-Acetylprocainamide. Angiology 37 (Pt 2):959, 1986
Braden GL, Fitzgibbons JP, Germain MJ, Ledewitz HM: Hemoperfusion for treatment of N-acetylprocainamide intoxication. Ann Intern Med 105:64–65, 1986
Connolly SJ, Kates RE: Clinical pharmacokinetic of N-acetylprocainamide. Clin Pharmacokinet 7:206, 1982
Domoto DT, Brown WW, Bruggensmith P: Removal of toxic levels of N Acetylprocainamide with continuous arteriovenous hemofiltration or continuous arteriovenous hemodiafiltration. Ann Intern Med 106:550, 1987
Drayer DE, Lowenthal DT, Woosley RL, Nies AS, Schwartz A, Reidenberg MM: Cumulation of N-acetylprocainamide, an active metabolite of procainamide, in patients with impaired renal function. Clin Pharmacol Ther 22:63, 1977
Gibson TP, Atkinson AJ jr, Matusik E, Nelson LD, Briggs WA: Kinetics of procainamide and N-acetylprocainamide in renal failure. Kidney Int 12:422, 1977
Kroboth PD, Mitchum K, Puschett JB: Use of procainamide in chronic ambulatory peritoneal dialysis: Report of a case. Am J Kidney Dis 4:78, 1984
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989:82, procainamide hydrochloride
Nattel S, Ogilvie RI, Krecft J et al.: Procainamide acetylation and disposition in dialysis patients. Clin Invest Med 2:5011, 1986
Raehl CI, Moorthy AV, Beirne GJ: Procainamide pharmacokinetics in patients on continuous ambulatory peritoneal dialysis. Nephron 44:191, 1986
Reidenberg MM, Camacho M, Kluger J, Drayer DE: Aging and renal clearance of procainamide and acetylprocainamide. Clin Pharmacol Ther 28:732, 1980
Ruo TI, Morita Y, Atkinson AJ jr, Heuthorn T, Thenot JP: Identification of desethyl procainamide in patients: A new metabolite of procainamide. J Pharmacol Exp Ther 216:357, 1981
Sica DA, Yonce C, Small R, Cefali E, Harford A, Poynor W: Pharmacokinetics of procainamide in continuous ambulatory peritoneal dialysis. Int J Clin Pharmacol Ther Toxicol 26:59, 1988
Singh S, Gelband H, Mehta AV, Kessler K, Casta A, Pickoff AS: Procainamide elimination kinetics in pediatric patients. Clin Pharmacol Ther 32:607, 1982
Stec GP, Atkinson AJ jr, Nevin ML, Thenot JP, Ruo TI, Gibson TP, Ivanovich P, del Greco F: N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis. Clin Pharmacol Ther 26:618, 1979
Villalba-Pimentel L, Epstein LM, Sellers EM, Foster JR, Bennion LJ, Nadler LM, Bough EW, Koch-Weser J: Survival after massive procainamide ingestion. Am J Cardiol 32:727, 1973
Vlasses PH, Ferguson RK, Rocci ML jr, Raja RM, Porter RS, Greenspan AM: Lethal accumulation of procainamide metabolite in severe renal insufficiency. Am J Nephrol 6:112, 1986
Windle J, Prystowsky EN, Miles WM, Heger JJ: Pharmacokinetic and electrophysiologic interactions of amiodarone and procainamide. Clin Pharmacol Ther 41:603, 1987
Yonce C, Sica D, Small R, Harford A, Poynor W: Pharmacokinetics of procainamide in continuous ambulatory peritoneal dialysis (CAPD). Clin Pharmacol Ther 35:285, 1984
Main references
Calvo R, Carlos R, Erill S: Effects of disease and acetazolamide on procaine hydrolysis by red cell enzymes. Clin Pharmacol Ther 27:175, 1980
Calvo R, Carlos R, Erill S: Procaine hydrolysis defect in uraemia does not appear to be due to carbamylation of plasma esterases. Eur J Clin Pharmacol 24:533, 1983
Greene NM: The metabolism of drugs employed in anesthesia. Anesthesiology 29:327, 1968
Kalow W: Hydrolysis of local anesthetics by human serum Cholinesterase. J Pharmacol Exp Ther 104:122, 1952
Martindale. The extra pharmacopoeia. 29th ed. London: The BPharmaceutical Press, 1989:1225, procaine hydrochloride
Reidenberg MM, James M, Dring LG: The rate of procaine hydrolysis in serum of normal subjects and diseased patients. Clin Pharmacol Ther 13:279, 1972
Seifen AB, Ferrari AA, Seifen AA, Thompson DS et al.: Pharmacokinetics of intravenous procaine infusion in humans. Anesth Analg 58:382, 1979
Tucker GT, Mather LE: Properties, absorption, and disposition of local anesthetic agents. In: Cousins MJ (ed): Neural blockade in clinical anesthesia and management of pain. 2nd ed. Philadelphia: JB Lippincott Co. 1988 p 47
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 648, procarbazine hydrochloride
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 763, prochlorperazine
Taylor WB, Bateman DN: Preliminary studies of the pharmacokinetics and pharmacodynamics of prochlorperazine in healthy volunteers. Br J Clin Pharmacol 23: 137, 1987
Main references
Dean K, Land G, Bye A: Analysis of procyclidine in human plasma and urine by gas-liquid chromatography. J Chromatogr 221: 408, 1980
Whiteman PD, Fowle ASE, Hamilton MJ, Peck AW, Bye A, Dean K, Webster A: Pharmacokinetics and pharmacodynamics of procyclidine in man. Eur J Clin Pharmacol 28: 73, 1985
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 1411, progesterone
Main references
Setnikar I, Arigoni R, Chiste R, Makovec F, Revel L: Plasma levels of Proglumetacin and its metabolites after intravenous or oral administration in the dog. Arzneimittelforschung (Drug Res) 37(I): 698, 1987
Main references
Arigoni R, Bignamini AA, Casula PL, Galeone M, Moise G, Setnikar I: Proglumide: Human pharmacokinetics after single and repeated intravenous or intramuscular administration. In: Weiss J, Miederer SE, (eds): Proglumide. Amsterdam, Oxford, Princeton: Exerpta Medica, 1980 p 107
Bignamini AA, von Hattingberg HL, Casula PL: Relevant therapeutic aspects of the pharmacokinetics of proglumide. In: Weiss J, Miederer SE, (eds): Proglumide. Amsterdam, Oxford: Excerpta Medica, 1979 p 49
Borghi CM, Cicchetti F, Bignamini AA, Casula PL, Setnikar I: Urinary excretion and plasma levels of proglumide after intravenous injection in patients with renal or liver failure. In: Weiss J, Miederer SE, (eds): Proglumide. Amsterdam, Oxford, Princeton: Excerpta Medica, 1980 p 95
von Bergmann K, Emker G, Röttger A, Leiss O, Kliems G: Pharmacokinetic of proglumide in renal and hepatic diseases. In: Rovati AL, Tsuchiya M, (eds): Proglumide. Amsterdam, Oxford, Princeton: Excerpta Medica, 1982 p 121
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 1145, prolactin
Main references
Croxson MS, Hall TD, Nicoloff JT: Combination drug therapy for treatment of hyperthyroid Graves’, disease. J Clin Endocrinol Metab 45: 623, 1977
Goodman and Gilman’s The pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985: 1389, chapter 60, Thyroid and antithyroid drugs by RC Haynes and F Murad
Kasai K, Suzuki H, Shimoda SI: Effects of propylthiouracil and relatively small doses of iodide on early phase treatment of hyperthyroidism. Acta Endocrinol (Copenh) 93: 315, 1980
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 459, promethazine
McAllister CJ, Scowden EB, Stone WJ: Toxic psychosis induced by phenothiazine administration in patients with chronic renal failure. Clin Nephrol 10: 191, 1978
Quinn J, Calvert R: The disposition of promethazine in man. J Pharm Pharmacol 28 (Suppl): 59P, 1976
Richet G, Lopez deeNovales E, Verroust P: Drug intoxication and neurological episodes in chronic renal failure. Br Med J 2: 394, 1970
Main references
Burgess E, Duff H, Wilkes P: Propafenone disposition in renal insufficiency and renal failure. J Clin Pharmacol 29: 112, 1989
Burgess ED, Duff HJ: Hemodialysis removal of propafenone. Pharmacotherapy 9: 331, 1989
Chan GLY, Axelson JE, Price JDE, McErlane KM, Kerr CR: In vitro protein binding of propafenone in normal and uraemic human sera. Eur J Clin Pharmacol 36: 495, 1989
Compostella L, Libardoni M, Faggion G, Martimbianco L, Moretto R, Padrini R, Pellanda MVB, Piovan D, Cucchini F: Pharmacokinetics of propafenone in chronically uremic patients on dialysis therapy. Preliminary results. In: Timio M, Venanzi S (eds): Heart and kidney. Proceedings of the first national convention on the heart in kidney disease and dialysis treatment, Assissi, March 26–28, 1987
Harron DWG, Brogden RN: Propafenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias. Drugs 34: 617, 1987
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 1124, propanidid
Simons F, Busse J, Klaschik E, Köppen R, Mauz G: Pathophysiologische Aspekte zur Anästhesie bei Niereninsuffizienz. Prakt Anästh 12: 110, 1977
Weir PHC, Chung FF: Anaesthesia for patients with chronic renal disease. Can Anaesth Soc J 31: 468, 1984
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 542, propantheline bromide
Main references
Emmerson JL, Welles JS, Anderson RC: Studies on the tissue distribution of d-propoxyphene. Toxicol Appl Pharmacol 11: 482, 1967
Giacomini KM, Gibson TP, Levy G: Plasma protein binding of d-propoxyphene in normal subjects and anephric patients. J Clin Pharmacol 18: 106, 1978
Giacomini KM, Gibson TP, Levy G: Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients. Clin Pharmacol Ther 27: 508, 1980
Gibson TP, Giacomini KM, Briggs WA, Whitman W, Levy G: Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient. Clin Pharmacol Ther 27: 665, 1980
Gram LF, Schou J, Way WL, Heltberg J, Bodin NO: d-Propoxyphene kinetics after single oral and intravenous doses in man. Clin Pharmacol Ther 26: 473, 1979
Mauer S, Paxson CL, von Hartizsch B, Buselmeier TJ, Kjellstrand CM: Hemodialysis in an infant with propoxyphene intoxication. Clin Pharmacol Ther 17: 88, 1975
McMahon RE, Ridolfo AS, Culp HW et al.: The fate of radiocarbon-labeled propoxyphene in rat, dog and human. Toxicol Appl Pharmacol 19: 427, 1971
Pearson RM: Pharmacokinetics of propoxyphene. Hum Toxicol 3 (Suppl): 37S, 1984
Wolen RL, Gruber CM, Kiplinger GF, Scholz NE: Concentration of propoxyphene in human plasma following oral, intramuscular and intravenous administration. Toxicol Appl Pharmacol 19: 480, 1971
Wolen RL, Ziege EA, Gruber CM jr: Determination of propoxyphene and norpropoxyphene by chemical ionization mass fragmentography. Clin Pharmacol Ther 17: 15, 1975
Main references
Agura ED, Wexler LF, Witzburg RA: Massive propranolol overdose. Successful treatment with high-dose isoproterenol and glucagon. Am J Med 80: 755, 1986
Bianchetti G, Graziani G, Brancaccio D, Morganti A, Leonetti G, Manfrin M, Sega R, Gomeni R, Ponticelli C, Morselli PL: Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment. Clin Pharmacokinet 1: 373, 1976
Borgström L, Johansson CG, Larsson H, Lenander R: Pharmacokinetics of propranolol. J Pharmacokinet Biopharm 9: 419, 1981
Lowenthal DT: Pharmacokinetics of propranolol, quinidine, procainamide and lidocaine in chronic renal disease. Am J Med 62: 532, 1977
Pritchard JF, Schneck DW, Hayes AH jr: Determination of propranolol and six metabolites in human urine by high-pressure liquid chromatography. J Chromatogr 162: 47, 1979
Routledge PA, Shand DG: Clinical pharmacokinetics of propranolol. Clin Pharmacokinet 4: 73, 1979
Schneck DW, Pritchard JF, Gibson TP, Vary JE, Hayes AH jr: Effect of dose and uremia on plasma and urine profiles of propranolol metabolites. Clin Pharmacol Ther 27: 744, 1980
Silber BM, Holford NHG, Riegelman S: Dose-dependent elimination of propranolol and its major metabolites in humans. J Pharm Sci 72: 725, 1983
Stone WJ, Walle T: Massive propranolol metabolite retention during maintenance hemodialysis. Clin Pharmacol Ther 28: 449, 1980
Talbert RL, Wong YY, Duncan DB: Propranolol plasma concentrations and plasmapheresis. Drug Intell Clin Pharm 15: 993, 1981
Thompson FD, Joekes AM, Foulkes DM: Pharmacodynamics of propranolol in renal failure. Br Med J 2: 434, 1972
Wood AJJ, Vestal RE, Spannuth CL, Stone WJ, Wilkinson GR, Shand DG: Propranolol disposition in renal failure. Br J Clin Pharmacol 10: 561, 1980
Zarate A, Gelfand M, Novello A, Knepshield J, Preuss HG: Propranolol-associated hypoglycemia in patients on maintenance hemodialysis. Int J Artif Organs 4: 130, 1981
Main references
Appel W, Sprengard D: Zur Pharmakokinetik von Propylhexedrine. Arzneimittelforschung (Drug Res) 21: 894, 1971
Haas H: Der Wirkungsmechanismus des l-1-Cyclohexyl-2-meth-ylaminopropan-5,5-phenyl-aethylbarbiturats und seine Eignung als Antiepileptikum. Arzneimittelforschung (Drug Res) 13: 613, 1963
Iven H, Feldbusch E: Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse. Naunyn Schmiedebergs Arch Pharmacol 324: 153, 1983
Midha KK, Beckett AH, Saunders A: Identification of the major metabolites of propylhexedrine in vivo (in man) and in vitro (in guinea pig and rabbit). Xenobiotica 4: 627, 1974
Main references
Alexander WD, Mcg Harden R, Shimmins J, McLarty D, McGill P: Development of thyroidal suppression by triiodothyronine during six months’ treatment of thyrotoxicosis with antithyroid drugs. J Clin Endocrinol Metab 27: 1682, 1967
Benker G, Reinwein D: Pharmacokinetics of antithyroid drugs. Klin Wochenschr 60: 531, 1982
Kampmann J, Skovsted L: The pharmacokinetics of propylthiouracil. Acta Pharmacol Toxicol (Copenh) 35: 361, 1974
Marchant B, Lees JF, Alexander WD: Antithyroid drugs. Pharmacol Ther (B) 3: 305, 1978
Ringhand HP, Ritschel WA, Meyer MC, Straughn AB, Hardt T: Pharmacokinetics of propylthiouracil upon p.o. administration in man. Int J Clin Pharmacol Ther Toxicol 18: 488, 1980
Sitar DS, Hunninghake DB: Pharmacokinetics of propylthiouracil in man after a single oral dose. J Clin Endocrinol Metab 40: 26, 1975
Main references General:
Clissold SP, Beresford R: Proquazone: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states. Drugs 33: 478, 1987
Renal damage:
Abraham PA, Keane WF: Glomerular and interstitial disease induced by nonsteroidal anti-inflammatory drugs. Am J Nephrol 4: 1, 1984
Carmichael J, Shankel SW: Effects of non-steroidal anti-inflammatory drugs on prostaglandins and renal function. Am J Med 78: 992, 1985
Clive DM, Stoff JS: Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N Engl J Med 310: 563, 1984
Duggin GG: Mechanisms in the development of analgesic nephropathy. Kidney Int 18: 553, 1980
Dunn MJ: Non-steroidal anti-inflammatory drugs and renal function. Annu Rev Med 35: 411, 1984
Hart D, Lifschitz MD: Renal physiology of the prostaglandins and the effects of nonsteroidal anti-inflammatory agents on the kidney. Am J Nephrol 7: 408, 1987
Henrich WL: Nephrotoxicity of nonsteroidal anti-inflammatory agents. Am J Kidney Dis 2: 478, 1982
Orme ML’E: Non-steroidal anti-inflammatory drugs and the kidney. Br Med J 292: 1521, 1986
Reeves WB, Foley RJ, Weinman EJ: Renal dysfunction from nonsteroidal anti-inflammatory drugs. Arch Intern Med 144: 1943, 1984
Simon LS, Mills JA: Nonsteroidal antiinflammatory drugs (First of two parts). N Engl J Med 302: 1179. 1980
Simon LS, Mills JA: Nonsteroidal antiinflammatory drugs (Second of two parts). N Engl J Med 302: 1237, 1980
Torres VE: Present and future of non-steroidal anti-inflammatory drugs in nephrology. Mayo Clin Proc 57: 389, 1982
Toto RD, Anderson SA, Brown-Cartwright D, Kokko JP, Brater DG: Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency. Kidney Int 30: 760, 1986
Wegmüller E: Nicht-steroidale Antirheumatika und Nephrotoxi-zität. Dtsch Med Wochenschr 110: 469, 1985
Main references
Belz GG, Stauch M, Rudofsky G: Plasma levels after a single oral dose of proscillaridin. Eur J Clin Pharmacol 7: 95, 1974
Belz GG, Brech WJ: Plasmaspiegel und Kumulationsverhalten von Proscillaridin bei Niereninsuffizienz. Klin Wochenschr 52: 640, 1974
Main references
Franz H, Urbanczik R, Stoll K, Müller U: Prothionamid-Blutspiegel nach oraler Verabreichung von Prothionamid allein oder kombiniert mit Isoniazid und/oder mit Diamino-Difenyl-sulfon. Prax Pneumol 28: 605, 1974
Höffler D: Antibiotika, Tuberkulostatika, Antimykotika — Dosierung bei Niereninsuffizienz. Innere Med 12: 85, 1985
Urbanczik R: Tuberkulosetherapie bei Patienten mit Niereninsuffizienz, Dialyse und nach Nierentransplantation. Prax Klin Pneumol 37: 436, 1983
Main references
Bassiri RM, Utiger RD: Metabolism and excretion of exogenous thyrotropin-releasing hormone in humans. J Clin Invest 52: 1616, 1973
Duntas L, Keck FS, Loos U, Pfeiffer EF: Pharmakokinetik und Pharmakodynamik von Protirelin (TRH) beim Menschen. Dtsch Med Wochenschr 113: 1354, 1988
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 1152, protirelin.
Main references
Biggs JT, Ziegler VE: Protriptyline plasma levels and antidepressant response. Clin Pharmacol Ther 22: 269, 1977
Charalampous KD, Johnson PC: Studies of C14-protriptyline in man: Plasma levels and excretion. J Clin Pharmacol 7: 93, 1967
Moody JP, Whyte SF, MacDonald AJ, Naylor GJ: Pharmacokinetic aspects of protriptyline plasma levels. Eur J Clin Pharmacol 11: 51, 1977
Sisenwine SF, Tio CO, Shrader SR, Ruelius HW: The biotransformation of protriptyline in man, pig and dog. J Pharmacol Exp Ther 175: 51, 1970
Ziegler VE, Biggs JT, Wylie LT et al.: Protriptyline kinetics. Clin Pharmacol Ther 23: 580, 1978
Main references
Graffner C, Johnsson G, Sjögren J: Pharmacokinetic studies on proxyphylline administered intravenously and orally to man. Acta Pharm Suec 10: 425, 1973
Ritschel WA: Biological half-lives of drugs. Drug Intell Clin Pharm 4: 332, 1970
Selvig K: Elimination of proxyphylline and its metabolites. Br J Clin Pharmacol 14: 608P, 1982
Main references
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 1478, pseudoephedrine
Main references
Andrew OT, Schoenfeld PY, Hopenell PC, Humphreys MW: Tuberculosis in patients with end-stage renal disease. Am J Med 68: 59, 1980
Bareggi SR, Cerutti R, Pirola R, Riva R, Cisternino M: Clinical pharmacokinetics and metabolism of pyrazinamide in healthy volunteers. Arzneimittelforschung (Drug Res) 37(II): 849, 1987
Ellard GA: Absorption, metabolism and excretion of pyrazinamide in man. Tubercle 50: 144, 1969
Höffler D: Antibiotika, Tuberkulostatika, Antimykotika — Dosierung bei Niereninsuffizienz. Innere Med 12: 85, 1985
Mitchison DA, Ellard GA: Tuberculosis in patients having dialysis. Br Med J 280: 1186, 1980
Mitchison DA, Ellard GA: Tuberculosis in patients having dialysis. Br Med J 280: 1533, 1980
Reed MD, Blumer JL: Clinical pharmacology of antitubercular drugs. Pediatr Clin North Am 30: 177, 1983
Urbanczik R: Tuberkulosetherapie bei Patienten mit Niereninsuffizienz, Dialyse und nach Nierentransplantation. Prax Klin Pneumol 37: 436, 1983
Zierski M: Pharmakologie, Toxikologie und klinische Anwendung von Pyrazinamid. Prax Klin Pneumol 35: 1075, 1981
Main references
Cohan SL, Pohlmann JLW, Mikszewki J, O’Doherty DS: The pharmacokinetics of pyridostigmine. Neurology (Minneap) 26: 536, 1976
Kornfeld P, Samuels AJ, Wolf RL, Osserman KE: Metabolism of 14C-labeled pyridostigmine in myasthenia gravis. Evidence for multiple metabolites. Neurology (Minneap) 20: 634, 1970
Somani SM, Roberts JB, Wilson A: Pyridostigmine metabolism in man. Clin Pharmacol Ther 13: 393, 1972
Main references
Anderson BB, Newmark PA, Rawlins M, Green R: Plama binding of vitamin B6 compounds. Nature 250: 502, 1974
Blumberg A, Hanck A, Sander G: Vitamin nutrition in patients on continuous ambulatory peritoneal dialysis (CAPD). Clin Nephrol 20: 244, 1983
Kopple JD, Mercurio K, Blumenkrantz RJ, Jones MR, Tallos J, Roberts C, Card B, Saltzman R, Casiato DA, Swendseid ME: Daily requirements for pyridoxine supplements in chronic renal failure. Kidney Int 19: 694, 1981
Lui A, Lumeng L, Aronoff GR, Li TK: Relationship between body store of vitamin B6 and plasma pyridoxal-P clearance: Metabolic balance studies in humans. J Lab Clin Med 106: 491, 1985
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 1270, pyridoxine hydrochloride
Mehansho H, Henderson LM: Transport and accumulation of pyridoxine and pyridoxal by erythrocytes. J Biol Chem 225: 11901, 1980
Merrill AH jr, Henderson JM, Wang E, McDonald BW, Millikan WJ: Metabolism of vitamin B-6 by human liver. J Nutr 114: 1664, 1984
Stein G, Sperschneider H, Koppe S: Vitamin levels in chronic renal failure and need for supplementation. Blood Purif 3: 52, 1985
Main references
Cavallito JC, Nichol CA, Brenckman WD, jr, Deangelis RL, Stickney DR, Simmons WS, Sigel CW: Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man. Drug Metab Dispos 6: 329, 1978
Martindale. The extra pharmacopoeia. 29th ed. London: The Pharmaceutical Press, 1989: 515, pyrimethamine
Nichol CA: Long plasma half life of pyrimethamine. Lancet II: 161, 1973
Smith CC, Ihrig J: Persistent excretion of pyrimethamine following oral administration. Am J Trop Med Hyg 8: 60, 1959
Weidekamm E, Plozza-Nottebrock H, Forgo I, Dubach UC: Plasma concentrations of pyrimethamine and sulfadoxine and evaluation of pharmacokinetic data by computerized curve fitting. Bull WHO 60: 115, 1982
Main references
Seyffart G: Ethinamate, methyprylon, other sedative-hypnotic drugs, and miscellaneous agents. In: Haddad LM, Winchester JF (eds): Clinical management of poisoning and drug overdose, Philadelphia: Saunders, 1983 p 542
Main references
Körner F, Nowak H: Zur Vitamin B6- und Antivitamin B6-Wirksamkeit von Pyridoxol-Derivaten unter besonderer Berücksichtigung des Pyrithioxins. Arzneimittelforschung (Drug Res) 17: 572, 1967
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Seyffart, G. (1991). P. In: Drug Dosage in Renal Insufficiency. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3804-8_16
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