Abstract
There is much evidence to support the association between pigmentary cholelithiasis and chronic haemolytic anaemias [1–5], including prosthetic heart valve-induced haemolysis [6]. In this which is a former malaria district over 10% of the population is formed by heterozygotes with β-thalassaemia trait. However, this being a condition which is found all over the world, it is possible to calculate that there are no fewer than 5 million carriers of the thalassaemic trait in the Mediterranean area alone [7].
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Alvisi, V., Pazzi, P., Sighinolfi, D. (1991). Prevalence of gallstone disease in thalassaemia minor. In: Capocaccia, L., Ricci, G., Angelico, F., Angelico, M., Attili, A.F., Lalloni, L. (eds) Recent Advances in the Epidemiology and Prevention of Gallstone Disease. Developments in Gastroenterology, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3744-7_11
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DOI: https://doi.org/10.1007/978-94-011-3744-7_11
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