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Oral Contraceptives and Breast Disease

  • Chapter
Book cover Approaches to Breast Cancer Prevention

Part of the book series: Developments in Oncology ((DION,volume 62))

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Abstract

Combined estrogen-progestogen oral contraceptives (OC) have been in use since 1960 and current estimates of worldwide use are 55–56 million women [1]. Such widespread use must be justified by a favorable risk/benefit ratio. Experimental evidence supports a role for hormones in breast disease [2–8], and animal studies have suggested that estrogens and progestogens may play a role in breast cancer [9–13]. Estrogens and progestogens are also known to affect the risk of cancer in other hormone-responsive tissues and while OC clearly decreases the risk of endometrial and ovarian cancers [14,15], estrogen unopposed by progestogen increases the risk of endometrial cancer [16,17].

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Authors
  1. Kathryn F. McGonigle
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  2. George R. Huggins
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Editor information

Editors and Affiliations

  1. Oncology Department St Thomas’ Hospital, and to Joint Breast Clinic, Royal Free Hospital, London, UK

    Basil A. Stoll FRCR, FFR (Honorary Consulting Physician) (Honorary Consulting Physician)

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© 1991 Springer Science+Business Media Dordrecht

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McGonigle, K.F., Huggins, G.R. (1991). Oral Contraceptives and Breast Disease. In: Stoll, B.A. (eds) Approaches to Breast Cancer Prevention. Developments in Oncology, vol 62. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3742-3_6

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  • DOI: https://doi.org/10.1007/978-94-011-3742-3_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5664-9

  • Online ISBN: 978-94-011-3742-3

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