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Predicting the Three-Dimensional Structure of Proteins by Homology-Based Model Building

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Theoretical and Computational Models for Organic Chemistry

Part of the book series: NATO ASI Series ((ASIC,volume 339))

Abstract

A priori prediction of the 3-D structure of proteins remains an important unsolved problem. Of the theoretical methods employed today, only homology-based model building produces protein structures of sufficient accuracy to be of use in structure-function and related studies. The present work provides a discussion of the features of protein structure which bear on homology-based model building in addition to a detailed description of the homology-based approach, with examples drawn from our own work.

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Authors and Affiliations

  1. Upjohn Laboratories, The Upjohn Company, Kalamazoo, MI, 49001, England

    Gerald M. Maggiora, S. Lakshmi Narasimhan, Cindy A. Granatir, James R. Blinn & Joseph B. Moon

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  1. Gerald M. Maggiora
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  2. S. Lakshmi Narasimhan
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  3. Cindy A. Granatir
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  4. James R. Blinn
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  5. Joseph B. Moon
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Editors and Affiliations

  1. Department of Chemistry, University of Coimbra, Coimbra, Portugal

    Sebastião J. Formosinho  & Luís G. Arnaut  & 

  2. Department of Chemistry, University of Toronto, Toronto, Canada

    Imre G. Csizmadia

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© 1991 Springer Science+Business Media Dordrecht

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Maggiora, G.M., Narasimhan, S.L., Granatir, C.A., Blinn, J.R., Moon, J.B. (1991). Predicting the Three-Dimensional Structure of Proteins by Homology-Based Model Building. In: Formosinho, S.J., Csizmadia, I.G., Arnaut, L.G. (eds) Theoretical and Computational Models for Organic Chemistry. NATO ASI Series, vol 339. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3584-9_9

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  • DOI: https://doi.org/10.1007/978-94-011-3584-9_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5589-5

  • Online ISBN: 978-94-011-3584-9

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