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Cultivation of Hepatocytes in a New Entrapment Reactor: a Potential Bioartificial Liver

  • Wei-Shou Hu
  • Scott L. Nyberg
  • Russell A. Shatford
  • William D. Payne
  • Frank B. Cerra

Abstract

Liver failure is a major cause of mortality.1 Most patients admitted to an intensive care unit in liver failure do not survive. Currently, the only available treatment for refractory liver failure is hepatic transplantation. Renal dialysis, which revolutionized the treatment of renal failure, does not have a hepatic equivalent. There is a critical demand to develop an artificial liver for short-term support of hepatic failure. Given the functional complexity of the liver, the most promising approach to the development of an artificial liver involves using cultivated hepatocytes to supply function.

Keywords

High Performance Liquid Chromatography Hollow Fiber High Performance Liquid Chromatography Analysis Hollow Fiber Membrane Unconjugated Bilirubin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • Wei-Shou Hu
    • 1
  • Scott L. Nyberg
    • 1
    • 2
  • Russell A. Shatford
    • 2
  • William D. Payne
    • 2
  • Frank B. Cerra
    • 2
  1. 1.Department of Chemical Engineering and Materials ScienceUSA
  2. 2.Department of SurgeryUniversity of MinnesotaMinneapolisUSA

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