Effects of Spinach on Growth of Human-Derived Normal and Cancer Cells

  • Z.-L. Kong
  • H. Murakami
  • K. Shinohara


Cultured animal cells are useful for evaluation of physiological functions of food components at the cellular level. Our previous studies have demonstrated that algal phycocyanins had a growth-promoting activity on some serum-free cultured human-derived cell lines (1). These suggest that the components of plants such as vegetables and fruits would also affect the growth of animal cells. We have found that extracts of vegetables and fruits had growth-promoting and -inhibiting effects on some human-derived normal and cancer cells (2). In this study, isolation of active principles of an aqueous dialyzate of spinach was done and the effects of each fraction on the growth of human-derived normal and cancer cell lines were examined.


S1102 Cell Breast Adenocarcinoma HB4C5 Cell National Food Research Institute eRDF Medium 
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    Shinohara, K., Okura, Y., Koyano, T., Murakami, H. and Omura, H. (1988)’Algal phycocyanins promote growth of human cells in culture‘, In Vitro Cellular & Developmental Biology, 24, 1057–1061.CrossRefGoogle Scholar
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    Mosmann, T.(1983)‘Rapid colorimetric assay for cellular growth and survival’, J. Immunol. Methods, 65, 55–63.PubMedCrossRefGoogle Scholar
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    Dodd, R. C., Cohn, M.S., Newman, S.L. and Gray, T.K.(1983)‘Vitamin D metabolites change the phenotype ofmonoblastic U-937 cells’, Proc. Natl. Acad. Sci. USA, 80, 7538–7541.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • Z.-L. Kong
    • 1
  • H. Murakami
    • 2
  • K. Shinohara
    • 3
  1. 1.Institute of Food Chemistry, Faculty of AgricultureKyushu UniversityHakozaki, FukuokaJapan
  2. 2.Graduate School of Genetic Resources Technology, Faculty of AgricultureKyushu UniversityHakozaki, FukuokaJapan
  3. 3.National Food Research InstituteThe Ministry of Agriculture, Forestry, and Fisheries, KannondaiTsukuba, IbarakiJapan

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