Formation of Multicellular Aggregates of Adult Rat Hepatocytes

  • Yasuyuki Sakai
  • Motoyuki Suzuki


Since hepatocytes in primary culture express various differentiated hepatic functions in vitro for a certain period of time, large scale culture of the cells with high density are expected to have many important applications. Particularly, a hybrid artificial liver using normal hepatocytes is expected for an effective treatment of acute hepatic failure.


Hepatic Function Large Scale Culture Spheroid Formation Acute Hepatic Failure Urea Synthesis 
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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • Yasuyuki Sakai
    • 1
  • Motoyuki Suzuki
    • 1
  1. 1.Institute of Industrial ScienceUniversity of TokyoMinato-ku, TokyoJapan

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