Abstract
When a drug is given orally, the proportion of the administered dose which reaches the systemic circulation varies widely, depending on the drug and the conditions of its use. Measurement of this proportion, and the rate f(t) at which the drug reaches the circulation, is an important part of drug development. The reconstruction of f(t) is an inference problem with sparse and noisy data. Estimates of f(t), the total amount of drug reaching the bloodstream, and other quantities of interest may be obtained, together with their uncertainties, using a Bayesian analysis in which entropy appears naturally in the prior probability.
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References
Charter, M.K.: 1990, ‘Drug Absorption in Man, and Its Measurement by MaxEnt’, in Maximum Entropy and Bayesian Methods, Dartmouth College 1989, P. Fougère (ed.), Kluwer, Dordrecht.
Gull, S.F.: 1989, ‘Developments in Maximum Entropy Data Analysis’, in Maximum Entropy and Bayesian Methods, Cambridge 1988, J. Skilling (ed.), Kluwer, Dordrecht.
Gull, S.F. and J. Skilling: 1989, Quantified Maximum Entropy “MEMSYS 3” Users’ Manual, Maximum Entropy Data Consultants Ltd., 33 North End, Meldreth, Royston, Herts, SG8 6NR, U.K.
Skilling, J.: 1989, ‘Classic Maximum Entropy’, in Maximum Entropy and Bayesian Methods, Cambridge 1988, J. Skilling (ed.), Kluwer, Dordrecht.
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© 1991 Springer Science+Business Media Dordrecht
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Charter, M.K. (1991). Quantifying Drug Absorption. In: Grandy, W.T., Schick, L.H. (eds) Maximum Entropy and Bayesian Methods. Fundamental Theories of Physics, vol 43. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3460-6_23
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DOI: https://doi.org/10.1007/978-94-011-3460-6_23
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5531-4
Online ISBN: 978-94-011-3460-6
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