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Effect of Purified Serum Amyloid a On Growth and Differentiation of Transformed Cells

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Amyloid and Amyloidosis 1990

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Abstract

The potential effect of the acute phase protein serum amyloid A (SAA) on the myeloid leukemia cell-line HL-60 was studied. Inhibition of cell proliferation was observed following 5 days incubation with 50μg/ml of purified SAA. This inhibitory level of SAA is within the range of SAA levels in cancer patients, in vivo. Purified SAA by itself affected differentiation of HL-60 cells. Concomitant addition of sodium butyrate (0.5mM) or TPA (10-8M) with purified SAA markedly potentiated the inhibitory effect on cell growth and enhanced the differentiation of these cells. These results suggest that SAA may play a role in modulation of cancer cells.

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References

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Author information

Authors and Affiliations

  1. Departments of Hematology, Soroka Medical Center and Ben-Gurion University of the Negev, P.O.Box 653, Beer-Sheva, Israel

    I. Nathan, D. Goldfarb, A. Dvilansky, Z. Zolotov & R. Shainkin-Kestenbaum

Authors
  1. I. Nathan
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  2. D. Goldfarb
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  3. A. Dvilansky
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  4. Z. Zolotov
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  5. R. Shainkin-Kestenbaum
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Editor information

Editors and Affiliations

  1. Institute of Immunology and Rheumatology, University of Oslo, Oslo, Norway

    Jacob B. Natvig

  2. Oslo Sanitetsforenings, Rheumatism Hospital, University of Oslo, Oslo, Norway

    Øystein Førre

  3. Department of Rheumatology, University of Tromsø, Tromsø, Norway

    Gunnar Husby

  4. Department of Immunology and Bloodbank, University of Tromsø, Tromsø, Norway

    Anne Husebekk  & Bjørn Skogen  & 

  5. Department of Biochemistry, University of Oslo, Oslo, Norway

    Knut Sletten

  6. Department of Pathology, University of Linköping, Linköping, Sweden

    Per Westermark

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© 1991 Springer Science+Business Media Dordrecht

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Nathan, I., Goldfarb, D., Dvilansky, A., Zolotov, Z., Shainkin-Kestenbaum, R. (1991). Effect of Purified Serum Amyloid a On Growth and Differentiation of Transformed Cells. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_36

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  • DOI: https://doi.org/10.1007/978-94-011-3284-8_36

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5450-8

  • Online ISBN: 978-94-011-3284-8

  • eBook Packages: Springer Book Archive

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