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Serum Amyloid A, an Acute Phase Protein, Inhibits Platelet Activation

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Abstract

Serum amyloid A is an acute phase protein known to circulate in blood as a component of high density lipoprotein. Platelets and mediators released from activated platelets are involved in various inflammatory reactions (1). It was, therfore, of interest to investigate whether this protein could play a role in modulating platelet function.

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References

  1. Oxholm, P. and Winther, K. (1986) Thrombocyte involvement in immune inflammatory reactions, Allergy 41, 1–10.

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  2. Rosenthal, CJ., Franklin, EC. Frangione, B. and Greenspan, J. (1976) Isolation and partial characterization of SAA—an amyloid-related protein from human serum, J Immunol 116, 1415–1418.

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  3. Benson, MD. and Aldo-Benson, M. (1979) Effect of purified SAA on immune response in vitro: Mechanisms of suppression, J Immunol 122, 2077–2082.

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© 1991 Springer Science+Business Media Dordrecht

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Zimlichman, S., Danon, A., Nathan, I., Mozes, G., Shainkin-Kestenbaum, R. (1991). Serum Amyloid A, an Acute Phase Protein, Inhibits Platelet Activation. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_33

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  • DOI: https://doi.org/10.1007/978-94-011-3284-8_33

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5450-8

  • Online ISBN: 978-94-011-3284-8

  • eBook Packages: Springer Book Archive

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