Neuro-Oncology pp 235-242 | Cite as

Comparative Effects of Dexamethasone and Methylprednisolone on Peritumoral Brain Edema

  • M. Zuccarello
  • D. Zerbi
  • G. Macchia
  • G. C. Andrioli
  • G. Schmitt
Part of the Developments in Oncology book series (DION, volume 66)


We evaluated the efficacy of methylprednisolone (MP) and dexamethasone (DM) in a randomized, prospective trial in 15 patients with primary and/or metastatic brain tumors. MP was given to 7 patients as an IV bolus of 1 gm, and tapered off in the following 7 days. DM was given to 8 patients at the daily dosage of 16 mgs for 7 days, and the day of surgery, and tapered off in the following 7 days. After 7 and 14 days, only the patients treated with MP showed a significant reduction in peritumoral brain edema volume measured by CT scan (P<0.01, P<0.0014, respectively). This study confirms the efficacy of MP in controlling peritumoral brain edema.


Brain Edema Sodium Succinate Metastatic Brain Tumor Vascular Permeability Factor Edema Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • M. Zuccarello
    • 1
    • 2
    • 3
  • D. Zerbi
    • 1
  • G. Macchia
    • 1
  • G. C. Andrioli
    • 1
  • G. Schmitt
    • 2
  1. 1.Galliera HospitalGenovaItaly
  2. 2.Department of Veterans AffairsU.S.A.
  3. 3.University of CincinnatiU.S.A.

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