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Neuro-Oncology pp 153-159 | Cite as

Clinical Application of Radiolabeled Human X Human Monoclonal Antibody with Interferon in the Treatment of Malignant Glioma—Preliminary Report

  • M. Nagai
  • T. Arai
  • K. Watanabe
  • K. Ichikawa
  • T. Watari
Chapter
Part of the Developments in Oncology book series (DION, volume 66)

Abstract

Clinical application of human monoclonal antibody (MAb) CLN-IgG was conducted to 7 patients of recurrent malignant glioma. 131-I labeled MAb was administered intratumorouly and scintigraphy was monitored. Specific incorporation of radioMAb was demonstrated on the image, indicating the 10% of radioactivity was distributed in the tumor region. Concomitant administration of interferon enhanced the efficacy of this therapy. The beneficial results have been obtained in 5 patients. No side effects was observed. This radio-immunotherapy holds future promise as a new therapeutic approach to malignant gliomas.

Keywords

Malignant Glioma Human Monoclonal Antibody Recurrent Malignant Glioma Neoplastic Meningitis Human Squamous Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • M. Nagai
    • 1
  • T. Arai
    • 1
  • K. Watanabe
    • 1
  • K. Ichikawa
    • 1
    • 2
  • T. Watari
    • 1
    • 2
  1. 1.Department of NeurosurgeryDokkyo University School of MedicineMibu, TochigiJapan
  2. 2.Department of RadiologyDokkyo University School of MedicineMibu, TochigiJapan

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