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Neuro-Oncology pp 153–159Cite as

Clinical Application of Radiolabeled Human X Human Monoclonal Antibody with Interferon in the Treatment of Malignant Glioma—Preliminary Report

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Part of the book series: Developments in Oncology ((DION,volume 66))

Abstract

Clinical application of human monoclonal antibody (MAb) CLN-IgG was conducted to 7 patients of recurrent malignant glioma. 131-I labeled MAb was administered intratumorouly and scintigraphy was monitored. Specific incorporation of radioMAb was demonstrated on the image, indicating the 10% of radioactivity was distributed in the tumor region. Concomitant administration of interferon enhanced the efficacy of this therapy. The beneficial results have been obtained in 5 patients. No side effects was observed. This radio-immunotherapy holds future promise as a new therapeutic approach to malignant gliomas.

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References

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Dokkyo University School of Medicine, Mibu, Tochigi, 321-02, Japan

    M. Nagai, T. Arai, K. Watanabe, K. Ichikawa & T. Watari

  2. Department of Radiology, Dokkyo University School of Medicine, Mibu, Tochigi, 321-02, Japan

    K. Ichikawa & T. Watari

Authors
  1. M. Nagai
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  2. T. Arai
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  3. K. Watanabe
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  4. K. Ichikawa
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  5. T. Watari
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Editor information

Editors and Affiliations

  1. University of Pavia, Pavia, Italy

    P. Paoletti (Professor of Neurosurgery), G. Butti (Assistant Professor of Neurosurgery) & S. Pezzotta (Associated Professor of Neurosurgery) (Professor of Neurosurgery),  (Assistant Professor of Neurosurgery) &  (Associated Professor of Neurosurgery)

  2. Department of Neurosurgery, University of Tokyo, Tokyo, Japan

    K. Takakura (Professor and Chairman) (Professor and Chairman)

  3. Division of Stroke and Trauma, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, U.S.A.

    M. D. Walker (Director) (Director)

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© 1991 Springer Science+Business Media Dordrecht

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Nagai, M., Arai, T., Watanabe, K., Ichikawa, K., Watari, T. (1991). Clinical Application of Radiolabeled Human X Human Monoclonal Antibody with Interferon in the Treatment of Malignant Glioma—Preliminary Report. In: Paoletti, P., Takakura, K., Walker, M.D., Butti, G., Pezzotta, S. (eds) Neuro-Oncology. Developments in Oncology, vol 66. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3152-0_26

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  • DOI: https://doi.org/10.1007/978-94-011-3152-0_26

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5390-7

  • Online ISBN: 978-94-011-3152-0

  • eBook Packages: Springer Book Archive

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