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Coexpression of PDGF and PDGF-Receptors Genes in Human Astrrocytic Gliomas

  • A. Mauro
  • A. Bulfone
  • A. Di Sapio
  • L. Sosso
  • D. Schiffer
Part of the Developments in Oncology book series (DION, volume 66)

Abstract

The expression of gene sequences related to PDGF A and B chains and of PDGF B-type receptor in human glioma biopsies was analyzed. The major part of astrocytic gliomas expressed transcripts for these genes at higher levels than found in peritumoral and in normal nervous tissue specimens. Our results are in agreement with the hypothesis of an autocrine growth stimulation in astrocytic gliomas, mediated by PDGF and PDGF receptors. Moreover, PDGF may be involved in paracrine mechanisms responsible for endothelial hyperplasias in malignant gliomas.

Keywords

Malignant Glioma Nervous Tissue Human Glioma Growth Stimulation PDGF Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Doolittle RF, Hunkapiller MW, Hood LE, Deware SG, Robbins KC, Aaronson SA, Antoniades HM (1983) ‘Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor’ Science 221:275–277.Google Scholar
  2. Heldin OH, Westermark B (1989) ‘Platelet-derived growth factor; three isoforms and two receptor types’. Trends in Genetics 5:108–111.PubMedCrossRefGoogle Scholar
  3. Johnsson A, Heldin C-H, Westermark B, et al, (1982) ‘Platelet-derived growth factor: identification of constituent polypeptide chains’. Biochem Biophys Res Commun 104:66–74.CrossRefGoogle Scholar
  4. Maxwell M, Naber SP, Wolfe HJ, Galanopoulos T, Hedley-Whyte ET, Black P McL, Antoniades HN (1990) ‘Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance’, J Clin Invest 86:131–140.PubMedCrossRefGoogle Scholar
  5. Press RD, Misra A, Samols D, Goldthwait DA, Mapstone TB (1989) ‘Major structural alterations of the c-sis gene are not observed in a series of tumors of the central nervous system’, J Neurooncol 7:345–356.PubMedGoogle Scholar
  6. Robbins KC, Aaronson SA (1988) ‘The sis oncogene. in Reddy EP, Skalka AM, Curran T (eds) The oncogene handbook. Elsevier Science Publishers), B.V., pp 427–452.Google Scholar
  7. Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin C-H, Huang HS, Dewel TF (1983) ‘Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus’, Nature 304:35–39.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • A. Mauro
    • 1
  • A. Bulfone
    • 1
  • A. Di Sapio
    • 1
  • L. Sosso
    • 1
  • D. Schiffer
    • 1
  1. 1.Dept. of NeurologyUniversity of TurinTorinoItaly

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