Coexpression of PDGF and PDGF-Receptors Genes in Human Astrrocytic Gliomas
The expression of gene sequences related to PDGF A and B chains and of PDGF B-type receptor in human glioma biopsies was analyzed. The major part of astrocytic gliomas expressed transcripts for these genes at higher levels than found in peritumoral and in normal nervous tissue specimens. Our results are in agreement with the hypothesis of an autocrine growth stimulation in astrocytic gliomas, mediated by PDGF and PDGF receptors. Moreover, PDGF may be involved in paracrine mechanisms responsible for endothelial hyperplasias in malignant gliomas.
KeywordsMalignant Glioma Nervous Tissue Human Glioma Growth Stimulation PDGF Receptor
Unable to display preview. Download preview PDF.
- Doolittle RF, Hunkapiller MW, Hood LE, Deware SG, Robbins KC, Aaronson SA, Antoniades HM (1983) ‘Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor’ Science 221:275–277.Google Scholar
- Maxwell M, Naber SP, Wolfe HJ, Galanopoulos T, Hedley-Whyte ET, Black P McL, Antoniades HN (1990) ‘Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance’, J Clin Invest 86:131–140.PubMedCrossRefGoogle Scholar
- Robbins KC, Aaronson SA (1988) ‘The sis oncogene. in Reddy EP, Skalka AM, Curran T (eds) The oncogene handbook. Elsevier Science Publishers), B.V., pp 427–452.Google Scholar