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Static and dynamic analysis of local control of coronary flow

  • Jenny Dankelman
  • Isabelle Vergroesen
  • Jos A. E. Spaan
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 124)

Abstract

Coronary flow is controlled by the myocardium at the tissue level. This local control can be characterized by two manifestations: the adaptation of blood flow to the level of oxygen consumption and the relative independence of blood flow from coronary arterial pressure. The former manifestation is referred to as flow adaptation to metabolism, the latter one as autoregulation. Alternative terms for flow adaptation to metabolism found in the literature are metabolic regulation and functional hyperemia. However, autoregulation may also be mediated by metabolic processes and therefore metabolic regulation is an ambiguous term. Hyperemia means ‘increased blood flow’ and consequently hyperemia implies the definition of a standard control value of flow. The term flow adaptation to metabolism, or simply flow adaptation, expresses the ability of the coronary system to adapt flow to metabolic needs of the heart, and is the term further used here.

Keywords

Coronary Flow Heart Rate Change Coronary Resistance Myogenic Response Flow Adaptation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1]
    Bache RJ, Dai XZ, Simon AB, Schwartz JS, Homans DC (1987) Effect of adenosine deaminase on coronary vasodilation during exercise. Circulation 76 Suppl IV: 146.Google Scholar
  2. [2]
    Bardenheuer H, Schrader J (1986) Supply-to-demand ratio for oxygen determines formation of adenosine by the heart. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H173–H180.PubMedGoogle Scholar
  3. [3]
    Belloni FL, Sparks HV (1977) Dynamics of myocardial oxygen consumption and coronary vascular resistance. Am. J. Physiol. 233 (Heart Circ. Physiol. 2): H34–H43.PubMedGoogle Scholar
  4. [4]
    Berne RM (1963) Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am. J. Physiol. 204: 317–322.PubMedGoogle Scholar
  5. [5]
    Broten TP, Romson JL, Fullerton DA, VanWinkle DM, Feigl EO (1989) Oxygen carbon dioxide control of coronary blood flow. FASEB J. 3: A973.Google Scholar
  6. [6]
    Broten TP, Feigl EO (1990) Role of oxygen and carbon dioxide in coronary autoregulation. FASEB J. 4: A403.Google Scholar
  7. [7]
    Chilian WM, Layne SM, Klausner EC, Eastham CL, Marcus ML (1989) Redistribution of coronary microvascular resistance produced by dipyridamole. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H383–H390.PubMedGoogle Scholar
  8. [8]
    Dankelman J, Spaan JAE, Stassen HG, Vergroesen I (1989) Dynamics of coronary adjustment to a change in heart rate in the anaesthetized goat. J. Physiol. Lond. 408: 295–312.PubMedGoogle Scholar
  9. [9]
    Dankelman J, Stassen HG, Spaan JAE (1990) System analysis of the dynamic response of the coronary circulation to a sudden change in heart rate. Med. Biol. Eng. Comp. 28: 139–148.CrossRefGoogle Scholar
  10. [10]
    Dankelman J, Spaan JAE, VanderPloeg CPB, Vergroesen I (1989) Dynamic response of the coronary circulation to a rapid change in its perfusion in the anaesthetized goat. J. Physiol. Lond. 419: 703–715.PubMedGoogle Scholar
  11. [11]
    Dole WP, Yamada N, Bishop VS, Olsson RA (1985) Role of adenosine in coronary blood flow regulation after reductions in perfusion pressure. Circ. Res. 56: 517–524.PubMedCrossRefGoogle Scholar
  12. [12]
    Drake-Holland AJ, Laird JD, Noble MIM, Spaan JAE, Vergroesen I (1984) Oxygen and coronary vascular resistance during autoregulation and metabolic vasodilation in the dog. J. Physiol. Lond. 348: 285–299.PubMedGoogle Scholar
  13. [13]
    Duling BR (1972) Microvascular responses to alterations in oxygen tension. Circ. Res. 31: 481–489.PubMedCrossRefGoogle Scholar
  14. [14]
    Edlund A, Fredholm BB, Patrignani P, Patrono C, Wennmalm A, Wennmalm M (1983) Release of two vasodilators, adenosine and prostacyclin, from isolated rabbit hearts during controlled hypoxia. J. Physiol Lond. 340: 487–502.PubMedGoogle Scholar
  15. [15]
    Eikens E, Wilcken DEL (1974) Reactive hyperemia in the dog heart: Effects of temporarily restricting arterial inflow and of coronary occlusions lasting one and two cardiac cycles. Circ. Res. 35: 702–712.PubMedCrossRefGoogle Scholar
  16. [16]
    Faber JE, Meininger GA (1990) Selective interaction of α-adrenoceptors with myogenic regulation of microvascular smooth muscle. Am. J. Physiol. 259 (Heart Circ. Physiol. 28: H1126–H1133PubMedGoogle Scholar
  17. [17]
    Ganz W, Tamura K, Marcus HS, Donoso R, Yoshida S, Swan HJC (1971) Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation 44: 181–195.PubMedCrossRefGoogle Scholar
  18. [18]
    Gellai M, Norton JM, Detar R (1973) Evidence for direct control of coronary vascular tone by oxygen. Circ. Res. 32: 279–289.PubMedCrossRefGoogle Scholar
  19. [19]
    Gerlach E, Dreisbach RH (1963) Der nucleotid-Abbau im Herzmuskel bei Sauerstoffmangel und seine mögliche Bedeutung fur die Coronardurch-blutung. Naturwiss 50: 228–229.CrossRefGoogle Scholar
  20. [20]
    Gibbs CL, Papadoyannis DE, Drake AJ, Noble MIM (1980) Oxygen consumption of the non-working and potassium chloride-arrested dog heart. Circ. Res. 47: 408–417.PubMedCrossRefGoogle Scholar
  21. [21]
    Gorczynski RJ, Duling BR (1978) Role of oxygen in arteriolar functional vasodilation in hamster striated muscle. Am. J. Phsyiol. 235 (Heart Circ. Physiol. 4): H505–H515.Google Scholar
  22. [22]
    Grande PO, Lundvall J, Mellander S (1977) Evidence for a rate-sensitive regulatory mechanism in myogenic microvascular control. Acta Physiol. Scand. 99: 432–447.PubMedCrossRefGoogle Scholar
  23. [23]
    Grande PO, Mellander S (1978) Characteristics of static and dynamic regulatory mechanisms in myogenic microvascular control. Acta Physiol. Scand. 102: 231–245.PubMedCrossRefGoogle Scholar
  24. [24]
    Grande PO, Borgstrom P, Mellander S (1979) On the nature of basal vascular tone in cat skeletal muscle and its dependence on transmural pressure stimuli. Acta Physiol. Scand. 107: 365–376.PubMedCrossRefGoogle Scholar
  25. [25]
    Granger HJ, Hester RK, Haensly WA (1982) Biochemistry and metabolism of coronary vessels. In: The Coronary Artery. Ed. Kalsner S. Oxford University press, New York: 168–186.Google Scholar
  26. [26]
    Granger HJ, Shepherd AP Jr (1973) Intrinsic microvascular control of tissue oxygen delivery. Microvasc. Res. 5: 49–72.PubMedCrossRefGoogle Scholar
  27. [27]
    Gregg DE (1963) Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium. Circ. Res. 13: 497–500.PubMedCrossRefGoogle Scholar
  28. [28]
    Hanley FL, Grattan MT, Stevens MB, Hoffman JIE (1986) Role of adenosine in coronary autoregulation. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H558–H566.PubMedGoogle Scholar
  29. [29]
    Kitamura K, Jorgensen CR, Gobel FL, Taylor HL, Wang Y (1972) Hemodynamic correlates of myocardial oxygen consumption during upright exercise. J. Appl. Physiol. 32: 516–522.PubMedGoogle Scholar
  30. [30]
    Koch AR (1964) Some mathematical forms of autoregulatory models. Circ. Res. 15 Suppl. I: 269–278.PubMedGoogle Scholar
  31. [31]
    Kroll K, Schipperheyn JJ, Hendriks FFA, Laird JD (1980) Role of adenosine in postocclusion coronary vasodilation. Am. J. Physiol. 238 (Heart Circ. Physiol. 7): H214–H219.PubMedGoogle Scholar
  32. [32]
    Kroll K, Feigl EO (1985) Adenosine is unimportant in controlling coronary blood flow in unstressed dog hearts. Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H1176–H1187.PubMedGoogle Scholar
  33. [33]
    Kuo LD, Davis MJ, Chilian WM (1990) Endothelium-dependent, flow-induced dilation of isolated coronary arterioles. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1063–H1070.PubMedGoogle Scholar
  34. [34]
    Kuo L, Chilian WM, Davis MJ (1990) Coronary arteriolar myogenic response is independent of endothelium. Circulation 66: 860–866.CrossRefGoogle Scholar
  35. [35]
    Laird JD, Breuls PNWM, VanDerMeer P, Spaan JAE (1981) Can a single vasodilator be responsible for both coronary autoregulation and metabolic vasodilation. Basic Res. Cardiol. 76: 354–358.PubMedCrossRefGoogle Scholar
  36. [36]
    Lansman JB (1988) Endothelial mechanosensors. Going with the flow. Nature 331: 481–482.PubMedCrossRefGoogle Scholar
  37. [37]
    McHale PA, Dubé GP, Greenfield JC Jr (1987) Evidence for myogenic vasomotor activity in the coronary circulation. Prog. Cardiovasc. Dis. 30: 139–146.PubMedCrossRefGoogle Scholar
  38. [38]
    McGillivray-Anderson KM, Faber JE (1990) Effect of acidosis on contraction of microvascular smooth muscle by α1 and α2-adrenoceptors. Implications for neural and metabolic regulation. Circ. Res. 66: 1643–1657.PubMedCrossRefGoogle Scholar
  39. [39]
    Meininger GA, Mack CA, Fehr KL, Bohlen HG (1987) Myogenic Vasoregulation overrides local metabolic control in resting rat skeletal muscle. Circ. Res. 60: 861–870.PubMedCrossRefGoogle Scholar
  40. [40]
    Mohrman DE, Feigl EO (1978) Competition between sympathetic vasoconstriction and metabolic vasodilation in the canine coronary circulation. Circ. Res. 42: 79–86.PubMedCrossRefGoogle Scholar
  41. [41]
    Olsson RA, Saito D, Steinhart CR (1982) Compartmentalization of the adenosine pool of dog and rat hearts. Circ. Res. 50: 617–626.PubMedCrossRefGoogle Scholar
  42. [42]
    Olsson RA, Snow JA, Gentry MK (1978) Adenosine metabolism in canine myocardial reactive hyperemia. Circ. Res. 42: 358–362.PubMedCrossRefGoogle Scholar
  43. [43]
    Rubio R, Berne RM (1975) Regulation of coronary blood flow. Prog. Cardiovasc. Dis. 18: 105–122.PubMedCrossRefGoogle Scholar
  44. [44]
    Sadick N, McHale PA, Dubé GP, Greenfield JC Jr (1987) Demonstration of coronary artery myogenic vasoconstriction in the awake dog. Basic Res. Cardiol. 82: 585–595.PubMedCrossRefGoogle Scholar
  45. [45]
    Saito D, Steinhart CR, Nixon DG, Olsson RA(1981) Intracoronary adenosine deaminase reduces canine myocardial reactive hyperemia. Circ. Res. 42: 1262–1267.CrossRefGoogle Scholar
  46. [46]
    Schrader J, Haddy FJ, Gerlach E (1977) Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia. Pflügers Arch 369: 1–6.PubMedCrossRefGoogle Scholar
  47. [47]
    Schwartz GG, McHale PA, Greenfield JC Jr (1982) Hyperemic response of the coronary circulation to brief diastolic occlusion in the conscious dog. Circ. Res. 50: 28–37.PubMedCrossRefGoogle Scholar
  48. [48]
    Schwartz GG, McHale PA (1982) Coronary vasodilation after a single ventricular extra-activation in the conscious dog. Circ. Res. 50: 38–46.PubMedCrossRefGoogle Scholar
  49. [49]
    Shepherd AP, Burgar CG (1977) A solid state arterio-venous oxygen difference analyzer for following whole blood. Am. J. Physiol. 232 (Heart Circ. Physiol. 1): H437–H440.PubMedGoogle Scholar
  50. [50]
    Spaan JAE (1985) Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance. Circ. Res. 56: 293–309.PubMedCrossRefGoogle Scholar
  51. [51]
    Sullivan SM, Johnson PC (1981) Effect of oxygen on blood flow autoregulation in cat sartorius muscle. Am. J. Physiol. 241 (Heart Circ. Physiol. 10: H807–H815.PubMedGoogle Scholar
  52. [52]
    VanBavel E (1989) Metabolic and myogenic control of blood flow studied on isolated small arteries. PhD Thesis. University of Amsterdam, The Netherlands.Google Scholar
  53. [53]
    VanBeek JHGM, Elzinga G (1986) Response time of mitochondrial O2 consumption to heart rate changes in isolated rabbit heart. Abstract Proc. Int. Union Physiol. Sci. 16: 485.Google Scholar
  54. [54]
    VanWezel HB, Bovill JG, Koolen JJ, Barendse GAM, Fiolet JWT, Dijkhuis JP (1987) Myocardial metabolism and coronary sinus blood flow during coronary artery surgery: Effects of nitroprusside and nifedipine. Am. Heart J. 113: 266–273.CrossRefGoogle Scholar
  55. [55]
    Vergroesen I, Dankelman J, Spaan JAE (1990) Static and dynamic control of the coronary circulation. In: Coronary circulation, basic mechanism and clinical relevance. Eds. Kajiya F, Klassen GA, Spaan JAE ,Hoffman JIE. Springer-Verlag Tokyo: 221–232.Google Scholar
  56. [56]
    Vergroesen I, Noble MIM, Wieringa PA, Spaan JAE (1987) Quantification of O2 consumption and arterial pressure as independent determinants of coronary flow. Am. J. Physiol. 252 (Heart Circ. Physiol. 21): H545–H553.PubMedGoogle Scholar
  57. [57]
    Vergroesen I, Spaan JAE (1988) Rate of decrease of myocardial O2 consumption due to cardiac arrest in anesthetized goats. Pflügers Arch. 413: 160–166.PubMedCrossRefGoogle Scholar
  58. [58]
    VonRestorff W, Holz J, Bassenge E (1977) Exercise induced augmentation of myocardial oxygen extraction in spite of normal coronary dilatory capacity in dogs. Pflügers Arch. 372: 181–185.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • Jenny Dankelman
  • Isabelle Vergroesen
  • Jos A. E. Spaan

There are no affiliations available

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