Water balance within the myocardium

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 124)


One of the roles of the microcirculation is to maintain the water balance between plasma and interstitium in the myocardium. Judged by the number of papers related to the interstitium and to the mechanics of coronary flow, the interstitium is a neglected field of research.


Left Ventricular Pressure Transmural Pressure Interstitial Pressure Oncotic Pressure Tissue Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. [1]
    Areskog NH, Arturson G, Grotte G, Wallenius G (1964) Studies on heart lymph. II. Capillary permeability of the dog’s heart, using dextran as a test substance. Acta Physiol. Scand. 62: 218–223.PubMedCrossRefGoogle Scholar
  2. [2]
    Aukland K, Nicolaysen G (1981) Interstitial fluid volume: local regulatory mechanisms. Physiol. Rev. 61: 556–643.PubMedGoogle Scholar
  3. [3]
    Bolwig TG, Lassen NA (1975) The diffusion permeability of water of the rat blood-brain barrier. Acta Physiol. Scand. 93: 415–422.PubMedCrossRefGoogle Scholar
  4. [4]
    Chvapil M (1967) Physiology of Connective Tissue. London, Butterworth: 417.Google Scholar
  5. [5]
    Crone C, Levitt DG (1984) Capillary permeability to small solutes. In: Handbook of Physiology. The cardiovascular system. Eds. Renkin EM, Michel CCH. Am. Physiol. Soc, Bethesda, 2 (IV) chapter 10: 411–466.Google Scholar
  6. [6]
    Curry FE (1984) Mechanics and thermodynamics of transcapillary exchange. In: Handbook of Physiology. The cardiovascular system. Eds. Renkin EM, Michel CCH. Am. Physiol. Soc, Bethesda, 2 (IV) chapter 8: 309–374.Google Scholar
  7. [7]
    Eichling JO, Raichle ME, Grubb Jr RL, Ter-Pogossian MM (1974) Evidence of the limitations of water as a freely diffusible tracer in brain of the rhesus monkey. Circ. Res. 35: 358–364.PubMedCrossRefGoogle Scholar
  8. [8]
    Eliassen E, Folkow B, Hilton SM, Öberg B, Rippe B (1974) Pressure volume characteristics of the interstitial fluid space in the skeletal muscle of the cat. Acta Physiol. Scand. 90: 583–593.PubMedCrossRefGoogle Scholar
  9. [9]
    Feldstein ML, Henquell L, Honig CR (1978) Frequency analysis of coronary intercapillary distances: site of capillary control. Am. J. Physiol. 235 (Heart Circ. Physiol. 4): H321–H325.PubMedGoogle Scholar
  10. [10]
    Guyton AC (1965) Interstitial Fluid pressure: II. Pressure volume curves of interstitial space. Circ. Res. 16: 452–460.PubMedCrossRefGoogle Scholar
  11. [11]
    Han Y, Vergroesen I, Spaan JAE (1990) Myocardial interstitial pressure is mainly caused by left ventricular pressure. Abstract. Circulation 82 Suppl. III: 380.Google Scholar
  12. [12]
    Harris TR, Gervin CA, Burks D, Custer P (1984) Effects of coronary flow reduction on capillary-myocardial exchange in dogs. Am. J. Physiol. 234 (Heart Circ. Physiol. 3): H679–H689.Google Scholar
  13. [13]
    Hevesy G, Jacobsen CF (1940) Rate of passage of water through capillary and cell walls. Acta Physiol. Scand. 1: 11–18.Google Scholar
  14. [14]
    Kedem O, Katchalsky A (1958) Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochem. Biophys. Acta 27: 229–246.PubMedCrossRefGoogle Scholar
  15. [15]
    Laine GA, Granger HJ (1985) Microvascular, interstitial and lymphatic interactions in normal heart. Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H834–H842.PubMedGoogle Scholar
  16. [16]
    Michel CCH (1984) Fluid movements through capillary walls. In: Handbook of Physiology. The cardiovascular system. Eds. Renkin EM, Michel CCH. Am. Physiol. Soc., Bethesda, 2 (IV) chapter 9: 375–409.Google Scholar
  17. [17]
    Michel CC, Mason JC, Curry FE, Tooke JE, Hunter P (1974) A development of the Landis technique for measuring the filtration coefficient of individual capillaries in the frog mesentery. Q. J. Exp. Physiol. 62: 1–10.Google Scholar
  18. [18]
    Miller AJ (1982) Lymphatics of the Heart. Raven Press, New York.Google Scholar
  19. [19]
    Miller AJ, Ellis A, Katz LN (1964) Cardiac lymph: flow rates and composition in dogs. Am. J. Physiol. 206: 63–66.PubMedGoogle Scholar
  20. [20]
    Perl W, Silverman F, Delea AC, Chinard FP (1976) Permeability of dog lung endothelium to sodium, diols, amides, and water. Am. J. Physiol. 230: 1708–1721.PubMedGoogle Scholar
  21. [21]
    Pogatsa G, Dubecz E, Gabor G (1976) The role of myocardial edema in the left ventricular diastolic stiffness. Basic Res. Cardiol. 71: 263–269.PubMedCrossRefGoogle Scholar
  22. [22]
    Polimeni PI (1974) Extracellular space and ionic distribution in rat ventricle. Am. J. Physiol. 227: 676–683.PubMedGoogle Scholar
  23. [23]
    Rose CP, Goresky CA, Bach GG (1977) The capillary and sarcolemmal barriers in the heart: an exploration of labeled water permeability. Circ. Res. 41: 515–533.PubMedCrossRefGoogle Scholar
  24. [24]
    Salisbury PF, Cross CE, Rieben PA (1962) Intramyocardial pressure and strength of left ventricular contraction. Circ. Res. 10: 608–623.PubMedCrossRefGoogle Scholar
  25. [25]
    Spaan JAE, Dankelman J (1989) Prediction of dynamic transcapillary pressure difference in the coronary circulation. In: Analysis and simulation of the cardiac system-Ischemia. Eds. Sideman S, Beyar R. CRC Press Boca Raton, Florida: 265–275.Google Scholar
  26. [26]
    Starling EH (1896) On the absorption of fluids from the connective tissue spaces. J. Physiol. Lond. 19: 312–326.PubMedGoogle Scholar
  27. [27]
    Stubbs J, Widdas WF (1959) The interrelationship of weight change and coronary flow in the isolated perfused rabbit heart. J. Physiol. London 148: 403–416.PubMedGoogle Scholar
  28. [28]
    Taira A, Matsuyama M, Morishita Y, Terashi I, Kawashima Y, Maruko M, Arikawa K, Murata K, Akita H (1976) Cardiac lymph and contractility of heart. Jap. Circ. J. 40: 665–670.PubMedCrossRefGoogle Scholar
  29. [29]
    Vargas FF, Blackshear GL, Majerle RJ (1980) Permeability and model testing of heart capillaries by osmotic and optical methods. Am. J. Physiol. 239 (Heart Circ. Physiol. 8): H464–H468.PubMedGoogle Scholar
  30. [30]
    Vargas FF, Blackshear GL (1981) Secondary driving forces affecting transcapillary osmotic flows in perfused heart. Am. J. Physiol. 240 (Heart Circ. Physiol. 9): H457–H464.PubMedGoogle Scholar
  31. [31]
    Vargas FF, Blackshear GL (1981) Transcapillary osmotic flows in the in vitro perfused heart. Am. J. Physiol. 240 (Heart Circ. Physiol. 9): H448–H456.PubMedGoogle Scholar
  32. [32]
    Vergroesen I, Noble MIM, Spaan JAE (1987) Intramyocardial blood volume change in first moments of cardiac arrest in anesthetized goats. Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H307–H316.PubMedGoogle Scholar
  33. [33]
    Yudilevich DL, Alvarez OA (1967) Water, sodium and thiourea trans-capillary diffusion in the dog heart. Am. J. Physiol. 213: 308–314.PubMedGoogle Scholar

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© Springer Science+Business Media Dordrecht 1991

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