5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in the central nervous system (CNS) and in the myenteric plexus of the gut. High concentrations are found in the enterochromafin cells in the lining of the alimentary canal and in the blood platelets. 5-HT is released from platelets at sites of tissue injury, and 5-HT in the systemic circulation (plasma) has a wide range of effects on nerve terminals and blood vessels which do not have a 5-HT innervation. The physiology and pharmacology of 5-HT is complex, for in addition to being a neurotransmitter it has local hormone or paracrine functions.
KeywordsRaphe Nucleus Tryptophan Hydroxylase Neuronal Uptake Presynaptic Nerve Terminal Diacyl Glycerol
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