Abstract
N-Oxidized compounds find extensive application as constituents of drugs, cosmetics, food and agricultural chemicals. Although very useful and almost indispensible, they can also produce adverse biological effects. These toxic (side-) effects include genotoxicity (carcinogenicity), but also immune diseases, such as allergy. Enzymatic activation of N-oxidized compounds as inducers of such processes has received much attention. It is assumed that reactive intermediates or instable products formed during (minor) metabolic processes damage biomacromolecules in the genetic or immune system.
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© 1991 Springer Science+Business Media Dordrecht
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Beijersbergen van Henegouwen, G.M.J. (1991). Phototoxic effects of N-oxidized drugs and related compounds. In: Hlavica, P., Damani, L.A. (eds) N-Oxidation of Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3112-4_26
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DOI: https://doi.org/10.1007/978-94-011-3112-4_26
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5378-5
Online ISBN: 978-94-011-3112-4
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