Abstract
The question why some individuals and not others get idiopathic Parkinson’s disease, which involves a selective degeneration of dopamine-containing cells in the substantia nigra, is still unanswered. The disease incidence in identical twins has shown no higher concordance than between random members of the population (Ward et al., 1983). The pattern of incidence has remained reasonably constant over time, and although there is some population clustering, it is insufficient to point to a clear environmental cause (Schoenberg, 1987). Other epidemiological findings amount to little. There is some evidence for an inverse relationship between smoking and Parkinson’s disease (Tanner et al., 1987), but the reason for this finding is unclear.
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Glover, V., Sandler, M. (1991). Monoamine oxidase-mediated activation of MPTP and related compounds. In: Hlavica, P., Damani, L.A. (eds) N-Oxidation of Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3112-4_21
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DOI: https://doi.org/10.1007/978-94-011-3112-4_21
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