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Role of cellular proteinases and their protein inhibitors in inflammation

  • Chapter
Biochemistry of Inflammation

Part of the book series: Immunology and Medicine Series ((IMME,volume 18))

Abstract

If immunological events are the trigger for inflammation, then proteinases provide the resultant explosions. The classic signs of inflammation: dolor, rubor, calor, and turgor are all dependent for their production on the action of proteolytic enzymes. There is no possibility of reviewing all of the proteinases involved in inflammation in a single chapter. There are literally scores of enzymes that would have to be considered. In order to reduce the number of proteases to a manageable size the following have been omitted in their entirety: all blood clotting factors, all complement factors (covered in Chapter 2 of this volume), the clot lysing system including plasmin and plasminogen activators, and all proteases that function intracellularly and do not escape to the exterior during inflammation. This latter group includes most membrane-bound proteases and cytoplasmic enzymes such as the calpains.

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Woessner, J.F. (1992). Role of cellular proteinases and their protein inhibitors in inflammation. In: Whicher, J.T., Evans, S.W. (eds) Biochemistry of Inflammation. Immunology and Medicine Series, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2996-1_4

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  • DOI: https://doi.org/10.1007/978-94-011-2996-1_4

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