Abstract
These two low molecular weight basic proteins are found almost exclusively in the alpha-granules of platelets and represent two of the earliest examples of the group of proteins now known collectively as the small inducible gene (SIG) family of proteins 1. For a more detailed description of the early developments leading up to the development of these two assays the interested reader is referred to a recent review chapter2.
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References
St Charles R, Walz DA, Edwards BFP The three dimensional structure of bovine platelet factor 4 at 3A resolution. J Biol Chem 1989; 264: 2092–9.
Pepper DS Radioimmunoassay of platelet proteins. In: Patrono C, Pesker BA eds., Handbook of experimental pharmacology, vol. 82. Berlin: Springer-Verlag, 1987; 517–41.
Walz DA Platelet release proteins as molecular markers for the activation process. Sem. Thromb Hemostas 1984; 16: 270–9.
Gregg EO, Yarwood L, Wagstatre MJ, Pepper DS, McDonald M Immunomodulatory properties of platelet factor 4: prevention of concanavalin A suppressor induction in vitro and augmentation of an antigen specific delayed type hypersensitivity response in vivo. Immunology 1990; 70: 230–4.
Walz A, Dewald B, Tscharner W, Baggiolini M Effects of the neutrophil activating peptide NAP-2, platelet basic protein, connective tissue activating peptide III and platelet factor 4 on human neutrophils. J Exp Med 1989; 170: 1745–50.
McClaren KM, Holloway L, Pepper DS Human platelet factor 4 and tissue mast cells, Thromb Res 1980; 19: 293–7.
Bolton AE, Ludlam CA, Moore S, Pepper DS, Cash JD Three approaches to the radioimmunoassay of human ß-thrombogiobulin. Br J Haematol 1976; 33: 233–8.
Van Oost BA, Veldhyzen B, Timmermans APM, Sixma JJ Increased urinary ß-thrombogiobulin excretion in diabetes assayed with a modified RIA kit-technique. Thromb Haemostas 1983; 49: 18–20.
Arocha-Pinango CL, Ojeda A, Lopez G, Garcia L, Linares J Beta-thrombogiobulin (beta-TG) and Platelet Factor 4 (PF4) in obstetrical cases. Acta Obstet. Sci. 1985; 2: 115–20.
Dawes J, Clemetson KJ, Gogstad GO, McGregor J, Clezardin P, Prowse CV, Pepper DS A radioimmunoassay for thrombospondin used in a comparative study of thrombospondin, ß-thrombogiobulin and platelet factor 4 in healthy volunteers. Thromb Res 1983; 29: 569–81.
Kerry PJ, Curtis AD Standardization of ß-thrombogiobulin (ßTG) and platelet factor 4 (PF4): a collaborative study to establish international standards for ßTG and PF4. Thromb Haemostas 1985; 53: 51–5.
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© 1992 Springer Science+Business Media Dordrecht
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Pepper, D.S., Prowse, C.V. (1992). Beta-thromboglobulin and platelet factor 4. In: Jespersen, J., Bertina, R.M., Haverkate, F. (eds) ECAT Assay Procedures A Manual of Laboratory Techniques. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2992-3_3
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DOI: https://doi.org/10.1007/978-94-011-2992-3_3
Publisher Name: Springer, Dordrecht
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