Abstract
Intestinal damage due to food hypersensitivity is a major cause of gastrointestinal morbidity in humans, especially in children. In the classical, delayed-onset intestinal hypersensitivities to dietary antigens (e.g. cereals and milk), the histopathological features associated with disease are small intestinal villous atrophy, crypt epithelial cell hyperplasia and crypt hypertrophy. There may also be abnormalities of surface epithelial cell structure and function. The clinical consequences of this enteropathy are malabsorption due to decreased absorptive surface, deficiency of digestive enzymes and steatorrhoea. The relative inaccessibility of clinical material from the intestine, and the difficulty in performing time-course studies in patients, has meant that our understanding of the development of the intestinal lesion in food-sensitive enteropathy is fragmentary. In addition, the immunological mechanisms which could cause tissue damage in the gut are not known, due to difficulties in obtaining lymphocytes from human gut and generating specific immune responses.
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Braegger, C.P., Macdonald, T.T. (1992). In vitro enteropathy. In: MacDonald, T.T. (eds) Immunology of Gastrointestinal Disease. Immunology and Medicine Series, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2978-7_8
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DOI: https://doi.org/10.1007/978-94-011-2978-7_8
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