Activators and Inhibitors of Complement

pp 167-180

Monoclonal antibodies against the terminal complement components

  • R. Würzner

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Classical or alternative pathway activation of the complement system results in the formation of the terminal complement complex (TCC), made up of the components C5, C6, C7, C8 and C9. In this review, the term membrane attack complex (MAC) is used only to describe the C5b-9(m) complex, the potentially membranolytic form of the TCC generated on biological membranes [1]. The term SC5b-9 is used to describe the generally non-lytic form of the TCC, generated in extracellular fluids in the presence of S-protein [2]. A diagram of the structures and assembly of C5–C9 is shown in Figure 1.