The Hypoxic Brain
We cherish our brains as the essence of what we are, how we think and feel, and the determiner of what we do. The sleep of acute, severe hypoxia is not necessarily reversible, as exemplified by the consequences of high altitude balloon flights of intrepid explorers of the upper atmosphere over a century ago (1,2). J.B.S. Haldane was the one who said that hypoxia not only stops the machine but wrecks the maehinery. My purpose will be to review the causes of hypoxia to the brain and to explore the limits of safe trespass and how one might try to recognize when one is approaching those limits. For general reviews of eerebral hypoxia, its metabolie correla tes, clinical and pathological consequences and brain protection, see references 3 and 4.
KeywordsCerebral Perfusion Pressure Severe Hypoxia Brain Hypoxia Hypoxic Ventilatory Response Arterial Hypoxemia
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