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Mechanisms of Lung Injury: An Overview

  • G. A. Zimmerman
Part of the Developments in Critical Care Medicine and Anesthesiology book series (DCCA, volume 25)

Abstract

One of the most rapidly evolving areas related to respiratory pathophysiology and disease involves the mechanisms of lung injury. Until a few years ago, pulmonary pathophysiology was domina ted by questions that involved the mechanisms by which gas flow and blood flow in the lung occur, how these two flows are regulated and matched, and how they are altered by disease. These questions were addressed by studies that involved the whole organ (the lung) and usually the whole organism. Such issues continue to be important, and the questions are not completely answered. However, in recent years much investigation has focused on the role of specific lung cells and their products in the functions of the normal lung, and on how cellular functions are altered in disease states. Information on the cell biology of lung disease is accumulating at a rapid rate, and is influencing the management of clinical lung problems. The emphasis on the cell biology and biochemistry of the lung has not replaced the traditional approach (based on gas and blood flow at the whole organ level) but it is definitely altering our understanding and view of these processes.

Keywords

Lung Injury Alveolar Macrophage Idiopathic Pulmonary Fibrosis Adult Respiratory Distress Syndrome Chemotactic Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McCord, J.M.. Oxygen radicals and lung injury; the state of the art. Chest (Suppl):35S–37S, 1983Google Scholar
  2. 2.
    Cambell E.J., Senior R.M. Cell injury and repair. Clin Chest Med 2:357–75, 1981Google Scholar
  3. 3.
    Chapman H.A., et al. Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. J Clin Invest 73:806–15, 1984PubMedCrossRefGoogle Scholar
  4. 4.
    Crystal R.G., et al: Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract. Parts I and II. N Eng J Med 1984; 310:154–65, 235–44CrossRefGoogle Scholar
  5. 5.
    Fantone J.C., et al: Chemotactic media tors in neutrophil-dependent lung injury. Annu Rev Physiol 44:283–93, 1982PubMedCrossRefGoogle Scholar
  6. 6.
    Reynolds N.Y.: Lung inflammation: Normal host defense or a complication of some diseases? Annu Rev Med 38:295–23, 1987PubMedCrossRefGoogle Scholar
  7. 7.
    Crystal R.G., West J.B., Bames P.J., Cherniack N.S., Weiber E.R. The Lung. Scientific Foundations. New York, Raven Press, 1991Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • G. A. Zimmerman

There are no affiliations available

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