Assessment of Respiratory Mechanics during Mechanical Ventilation

  • J. Milic-Emili
  • N. T. Eissa
Part of the Developments in Critical Care Medicine and Anesthesiology book series (DCCA, volume 25)


There have been relatively few systematic measurements of respiratory meehanics in mechanically ventilated humans, probably reflecting the notion that under these conditions respiratory mechanics data are diffieult to obtain. In reality, during mechanical ventilation a detailed analysis of respiratory mechanics can be readily performed. In this article, we will focus on the technique of rapid airway occlusion during constant-flow inflation because it can be used with commercial ventilators (e.g., Siemens Servo 900e). Such ventilators are versatile and have built-in devices for measuring flow and pressure.


Adult Respiratory Distress Syndrome Respiratory Mechanic Alveolar Pressure Airway Occlusion Increase Lung Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Neergaard K., von, Wirz K.: Die Messung der Strömungswiderstand in der Atemwege des Menschen insbesondere bei Asthma und Emphysema. Z Klin Med 105:51–82, 1927Google Scholar
  2. 2.
    O’Angelo E., Calderini E., Torri G., et al: Respiratory mechanics in anesthetized paralyzed humans: effects of flow, volume and time. J Appl Physiol 67:1556–64, 1989Google Scholar
  3. 3.
    O’Angelo E., Robatto F.M., Calderini E., et al: Pulmonary and ehest wall mechanics in anesthetized paralyzed humans. J Appl Physiol 70:2602–10, 1991Google Scholar
  4. 4.
    Similowski T., Levy P., Corbeil C., et al: Viseoelastic behaviour of lung and chest wall in dogs determined by flow interruption. J Appl Physiol 67:2219–29, 1989PubMedGoogle Scholar
  5. 5.
    Bates J.H.T., Ludwig M.S., Sly P.D., et al: Interrupter resistanee elucidated by alveolar pressure measurement in open-ehest normal dogs. J Appl Physiol 64:408–14, 1988Google Scholar
  6. 6.
    Bates J.H.T., Rossi A., Milie-Emili J.: Analysis of the behaviour of the respiratory system with eonstant inspiratory flow. J Appl Physiol 58:1840–8,1985PubMedGoogle Scholar
  7. 7.
    Behrakis P.K., Higgs B.C., Baydur A., et al: Respiratory meehanics during halothane anesthesia and anesthesia-paralysis in humans. J Appl Physiol 55:1085–92, 1983PubMedGoogle Scholar
  8. 8.
    Don H.F., Robson J.G.: The meehanics of the respiratory system during anesthesia: The effect of atropine and earbon dioxide. Anesthesiology 26:168–78,1965PubMedCrossRefGoogle Scholar
  9. 9.
    Fredberg J.J., Ingram R.H., Castille R.G., et al: Nonhomogeneity of lung response to inhaled histamine assessed with alveolar eapsules. J Appl Physiol 58:1914–22, 1985PubMedGoogle Scholar
  10. 10.
    Koehi T., Okubo S., Zin W.A., Milie-Emili J.: Flow and volume dependenee of pulmonary meehanics in anesthetized eats. J Appl Physiol 64:2636–46, 1988Google Scholar
  11. 11.
    Martins M.A., Saldiva P.H.N., Caldeira M.P.R., et al: Respiratory system, lung, and chest wall mechanics in guinea pigs. Brazilian J Med Biol Res 21:353–63, 1988Google Scholar
  12. 12.
    Otis A.B., MeKerrow C.B., Bartlett R.A., et al: Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol 8:427–43, 1956PubMedGoogle Scholar
  13. 13.
    Barnas G.M., Yoshino K., Loring S.H., Mead J.: Impedanee and relative displacements of the relaxed ehest wall up to 4 Hz. J Appl Physiol 62:71–81,1987PubMedGoogle Scholar
  14. 14.
    Barnas G.M., Yoshino K., Stamenovie D., et al: Chest wall impedanee partitioned into rib cage and diaphragm-abdominal pathways. J Appl Physiol 66:350–9, 1989CrossRefGoogle Scholar
  15. 15.
    Rossi A., Gottfried S.B., Higgs B.D., et al: Respiratory mechanics in mechanically ventilated patients. J Appl Physiol 58:1849–58, 1985PubMedGoogle Scholar
  16. 16.
    Broseghini C., Brandolese R., Poggi R., et al: Respiratory meehanies during the first day of mechanical ventilation in patients with pulmonary edema and chronic airway obstruction. Am Rev Respir Dis 138:355–61,1988PubMedGoogle Scholar
  17. 17.
    Rossi A., Gottfried S.B., Zocchi L., et al: Measurement of static compliance of the total respiratory system in patients with aeute respiratory failure during mechanical ventilation. Am Rev Respir Dis 131:672–7, 1985PubMedGoogle Scholar
  18. 18.
    Jonson B., Nördstrom L., Olsson S.G., Akerbaek D.: Monitoring of ventilation and lung mechanics during automatic ventilation. A new device. Bull Eur Physiopathol Respir 11:729–43, 1975Google Scholar
  19. 19.
    Pepe P.E., Marini J.J.: Occult positive end-expiratory pressure in mechanically ventilated patients with airflow obstruction. Am Rev Respir Dis 126:166–70, 1982PubMedGoogle Scholar
  20. 20.
    Milie-Emili J., Robatto F.M., Bates J.H.T.: Respiratory mechanics in anesthesia. Br J Anaesthesia 65:4–12, 1990CrossRefGoogle Scholar
  21. 21.
    Mead J., Agostoni E.: Dynamics of Breathing, Handbook of Physiology. Vol. 1. Maeklem P.T., Mead J. (eds). Am Physiol Soc, Washington, DC, sect. 3, chapt. 14,1964, pp. 411Google Scholar
  22. 22.
    Eissa N.T., Ranieri V.M., Corbell C., et al: Analysis of behavior of the respiratory system in ARDS patients: effects of flow, volume, and time. J Appl Physiol 70:2719–29, 1991PubMedCrossRefGoogle Scholar
  23. 23.
    Hildebrandt J.: Pressure-volume data of eat lung interpreted by a plastoelastic linear viscoelastic model. J Appl Physiol 28:365–72, 1970PubMedGoogle Scholar
  24. 24.
    Bates J.H.T., Baconnier P., Milic-Emili J.: A theoretical analysis of the interrupter technique for measuring respiratory meChanics. J Appl Physiol 64:2204–14,1988PubMedGoogle Scholar
  25. 25.
    Briscoe W. A., Dubois A.B.: The relationship between airway resistanee, airway conductance and lung volume in subjects of different age and body size. J Clin Invest 37:1279–85, 1958PubMedCrossRefGoogle Scholar
  26. 26.
    Bates J.H.T., Hunter I., Sly P.D., et al: The effect of closure time on the determination of respiratory resistance by flow interruption. Med Biol Eng Comput 25:136–40, 1987PubMedCrossRefGoogle Scholar
  27. 27.
    Sly P.D., Bates J.H.T., Milic-Emili J.: Measurement of respiratory mechanics using the Siemens Servo Ventilator 900e. Ped Pulm 3:400–5,1987CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • J. Milic-Emili
  • N. T. Eissa

There are no affiliations available

Personalised recommendations