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The Nicotinic Acetylcholine Receptor, A Model of Ligand-Gated Ion Channels

Investigation of its functional organization by protein chemistry and site-directed mutagenesis

  • Conference paper
Membrane Proteins: Structures, Interactions and Models

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 25))

Abstract

Upon rapid release from the nerve terminal at a 0.1-1mM concentration, the neurotransmitter acetylcholine (ACh) diffuses through the synaptic cleft separating motoneuron and skeletal muscle, and causes the all-or-none opening of ionic channels from the post-synaptic membrane. Ion flux through these channels selective for sodium, potassium and other small cations (Adams et al. 1980), leads to the depolarization of the post-synaptic cell, and then to muscle contraction.

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  1. Laboratoire de Neurobiologie Moléculaire Unité associée au CNRS UA D1284, Institut Pasteur, 25, rue du Dr Roux, Paris, 75724, France

    Jean-Luc Galzi & Jean-Pierre Changeux

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  1. Jean-Luc Galzi
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  2. Jean-Pierre Changeux
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  1. Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild, Paris, France

    Alberte Pullman  & Bernard Pullman  & 

  2. Department of Chemistry, University of Tel-Aviv, Israel

    Joshua Jortner

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Galzi, JL., Changeux, JP. (1992). The Nicotinic Acetylcholine Receptor, A Model of Ligand-Gated Ion Channels. In: Pullman, A., Jortner, J., Pullman, B. (eds) Membrane Proteins: Structures, Interactions and Models. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2718-9_12

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  • DOI: https://doi.org/10.1007/978-94-011-2718-9_12

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