Abstract
Familial aggregation and twin studies suggest that both coronary heart disease and hypertension have genetic determinants. In hypertension, studies on adopted offspring and parents have been done to confirm the important role of heredity in the determination of blood pressure. However, all data also indicate that hereditary factors alone do not account for the findings and that various environmental factors are playing an important pathogenetic role. The role of modern genetic analysis consists in the elucidation and definition of specific genes and their products that predispose individuals to cardiovascular disease. Genes that have a large effect on the trait under study are of particular interest. New methodology using molecular and biochemical techniques together with novel genetic-statistical approaches are used.
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References
Breslow J. L. (1989): Genetic basis of lipoprotein disorders. J. Clin. Invest., 84: 373–380.
Deeb S., Failor A., Brown B. G., Brunzell J. D., Albers J. J., Motulsky A. G. (1986): Molecular genetics of apolipoproteins and coronary heart disease. Cold Spring Harbor Symp. Quant. Biol., LI: 403–409.
Grundy S. M., Vega G. L. (1990): Causes of high blood cholesterol. Circulation, 81: 412–427.
Hobbs H. H., Russell E. W., Brown M. S., Goldstein J. L. (1990): The LOL receptor locus in familial hypercholesterolemia. Mutational analysis of a membrane protein. Annu. Rev. Genet. 24: 133–170.
Innerarity T. L., Mahley R.W., Weisgraber K. H., Bersot T. P., Krauss R. M., Vega G. L., Grundy S. M., Friedl W., Davignon J., McCarthy B. J. (1990): Familial defective apolipoprotein B-1OO: a mutation of apolipoprotein B that causes hypercholesterolemia. J. Lipid Res., 31: 1337–1349.
Lusis A. G., Sparkes R. S. (editors) (1989): Genetic Factors in Atherosclerosis: Approaches and Model Systems. (Monographs in Human Genetics, vol. 12). Karger, Basel.
Motulsky A. G., Burke W., Billings P. R., Ward R.H. (1987): Hypertension and the genetics of red cell membrane abnormalities. Ciba Found. Symp., 130: 150–166.
Motulsky A. G. (1989): Genetic aspects of familial hypercholesterolemia and its diagnosis. Arteriosclerosis, Suppl. 1:3–7.
Sing C. F., Moll P. P. (1990): Genetics of atherosclerosis. Ann. Rev. Genet., 24: 171–187.
Utermann G: The mysteries of lipoprotein(a). Science 246:904–910, 1989
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© 1992 Springer Science+Business Media Dordrecht
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Motulsky, A.G. (1992). The Role of Genetics as a Risk Factor in Cardiovascular Disease. In: Gotto, A.M., Lenfant, C., Paoletti, R., Soma, M. (eds) Multiple Risk Factors in Cardiovascular Disease. Medical Science Symposia Series, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2700-4_4
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DOI: https://doi.org/10.1007/978-94-011-2700-4_4
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