Abstract
The fibric acid derivatives (fibrates) form a family of hypolipidemic drugs whose structure and mode of action are closely related to that of the parent compound clofibrate (p-chlorophenoxyisobutyric acid). Clofibrate (Atromid-S) was introduced into the UK in 1962 and found wide application as a lipid lowering agent. However, its limited efficacy and its poor benefit to risk ratio in the W.H.O. trial (3) have led to a steady decline in its use since 1978 (13). Second and third generation fibrates eg bezafibrate, fenofibrate and gemfibrozil have been developed and marketed as useful agents for the treatment of hypertriglyceridemia where they are first line therapies and, hypercholesterolemia where they are used either as first line or second line when bile acid sequestrant resin therapy fails. They are also commonly used in combination regimens with the resins cholestyramine and colestipol.
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© 1992 Springer Science+Business Media Dordrecht
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Gaw, A., Griffin, B.A., Caslake, M.J., Packard, C.J., Shepherd, J. (1992). Fibrates and Reversal of Atherogenic Particles. In: Gotto, A.M., Lenfant, C., Paoletti, R., Soma, M. (eds) Multiple Risk Factors in Cardiovascular Disease. Medical Science Symposia Series, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2700-4_34
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DOI: https://doi.org/10.1007/978-94-011-2700-4_34
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