Abstract
Radiolabeled cellular blood elements for diagnostic applications have passed the test of time and become an established modality in nuclear medicine. Cell preparations must be performed in vitro either in hospital radiopharmacies, or in some centers, by commercial vendors. Generally the procedure has proven to be safe and reliable but risks remain from handling of contaminated blood samples and from accidental mix up of samples from cases involving ubiquitous bacterial infection, hepatitis or acquired immunodeficiency syndrome (AIDS).
The advent of hybridoma technology has led investigators to the development of monoclonal antibodies specific for a variety of cellular blood elements. When radiolabeled and administered directly, these agents in principle, can label the chosen type of blood element in vivo and simplify the cell labeling procedure.
This article summarizes the early results of this exciting development, discusses its virtues and limitations, and points out the future possibilities as envisioned with our own experience in imaging inflammatory foci in patients.
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Thakur, M.L. (1992). Cell Labeling in Radiopharmacy: What Can Radiolabeled Monoclonal Antibodies Offer?. In: Schubiger, P.A., Westera, G. (eds) Progress in Radiopharmacy. Developments in Nuclear Medicine, vol 22. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2584-0_5
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DOI: https://doi.org/10.1007/978-94-011-2584-0_5
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