Advertisement

Myocardial perfusion imaging with technetium-99m teboroxime

  • Robert C. Hendel
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 133)

Abstract

Myocardial perfusion imaging at rest and following stress is an extensively utilized and widely accepted method for the detection and evaluation of coronary artery disease. Perfusion imaging, in conjunction with exercise or pharmacologic hyperemia, provides physiologic information regarding coronary blood flow reserve and is often complementary to the anatomic data obtained through coronary angiography. Although thallium-201 has been used in clinical practice for more than 15 years and has demonstrated both diagnostic and prognostic value, its availability, as it is a cyclotron-produced product, may be limited. Furthermore, its photon energy is not well suited for an Anger camera and its prolonged half-life limit the dosimetry which results in less photon flux.

Keywords

Myocardial Perfusion Myocardial Perfusion Imaging Viable Myocardium Coronary Blood Flow Perfusion Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Narra RK, Nunn AD, Kuczynski BL, Feld T, Wedeking P, Eckelman WC. A neutral technetium-99m complex for myocardial imaging. J Nucl Med 1989; 30: 1830–7.PubMedGoogle Scholar
  2. 2.
    Stewart RE, Schwaiger M, Hutchins GD et al. Myocardial clearance kinetics of technetium-99m-SQ30217: a marker of regional myocardial blood flow. J Nucl Med 1990; 31: 1183–90.PubMedGoogle Scholar
  3. 3.
    Coleman RE, Maturi M, Nunn AD, Eckelman WC, Cobb FR. Myocardial perfusion: comparison of SQ 30217, thallium-201 and microspheres in dogs [abstract]. J Nucl Med 1987; 28 suppl: 1080.Google Scholar
  4. 4.
    Li QS, Solot G, Frank TL, Wagner HN Jr, Becker LC. Serial rest and dipyridamole tomographic myocardial perfusion studies with the rapidly clearing Tc-99m agent SQ 30217 [abstract]. J Nucl Med 1988; 29 Suppl: 938.Google Scholar
  5. 5.
    Beanlands R, Muzik O, Nguyen N, Schwaiger M. Comparison of the myocardial retention of technetium-99m-teboroxime and thallium-201 [abstract]. J Am Coll Cardiol 1991; (2 Suppl A): 252A.Google Scholar
  6. 6.
    Beanlands R, Muzik O, Nguyen N, Petry N, Schwaiger M. The relationship of technetium-99m teboroxime retention and myocardial blood flow [abstract]. J Nucl Med 1991; 32 Suppl: 947.Google Scholar
  7. 7.
    Mousa SA, Williams SJ, Sands H. Characterization of in vivo chemistry of cations in the heart. J Nucl Med 1987; 28: 1351–7.PubMedGoogle Scholar
  8. 8.
    Johnson LL, Seldin DW. Clinical experience with technetium-99m teboroxime, a neutral, lipophilic myocardial perfusion agent. Am J Cardiol 1990; 66: 63E–67E.PubMedCrossRefGoogle Scholar
  9. 9.
    Leppo JA, Meerdink DJ. Comparative myocardial extraction of two technetium-labeled BATO derivatives (SQ30217, SQ32014) and thallium. J Nucl Med 1990; 31: 67–74.PubMedGoogle Scholar
  10. 10.
    Nakajima K, Taki J, Bunko H et al. Dynamic acquisition with a three-headed SPECT system; application to technetium 99m-SQ30217 myocardial imaging. J Nucl Med 1991; 32: 1273–7.PubMedGoogle Scholar
  11. 11.
    Rumsey WL, Rosenspire K, Nunn AD. Extraction and metabolism of teboroxime in the isolated perfused rat heart [abstract]. J Nucl Med2 1991; 32 Suppl: 948.Google Scholar
  12. 12.
    Dahlberg ST, Gilmore MP, Siwko R, Leppo JA. Incubation with red blood cells reduces the extraction of technetium-99m teboroxime in the isolated rabbit heart [abstract]. J Nucl Med 1991; 32 Suppl: 910.Google Scholar
  13. 13.
    Seldin DW, Johnson LJ, Blood DK et al. Myocardial perfusion imaging with technetium-99m SQ30217: comparison with thallium-201 and coronary anatomy. J Nucl Med 1989; 30: 312–9.PubMedGoogle Scholar
  14. 14.
    Gray W, Gewirtz H. Evidence of differential washout of Tc-99m teboroxime from normal and ischemic myocardium [abstract]. J Am Coll Cardiol 1991; 17 (2 Suppl A): 286A.CrossRefGoogle Scholar
  15. 15.
    Glover DK. Okada RD, Hebert CB. Tc-99m-teboroxime (SQ30217 Cardiotec) kinetics in normal and ischemic canine myocardium [abstract]. Circulation 1990; 82 (4 Suppl III): III486.Google Scholar
  16. 16.
    Johnson G3d, Okada RD, Hebert CB. Myocardial kinetics of technetium-99m teboroxime in a canine stenosis model following dipyridamole [abstract]. J Nucl Med 1991; 32 Suppl: 948.Google Scholar
  17. 17.
    Hendel RC, McSherry B, Karimeddini M, Leppo JA. Diagnostic value of a new myocardial perfusion agent, teboroxime (SQ 30217), utilizing a rapid planar imaging protocol: preliminary results. J Am Coll Cardiol 1990; 16: 855–61.PubMedCrossRefGoogle Scholar
  18. 18.
    Levine D, Gewirtz H. Evidence of differential technetium-99m teboroxime washout in myocardial images of patients with known or suspected ischemic heart disease [abstract]. J Nucl Med 1991; 32 Suppl: 930.Google Scholar
  19. 19.
    Dahlberg ST, Gilmore M, Meerdink DJ, Leppo JA. Effect of global cardiac ischemia and reperfusion on the extraction of thallium-201 and technetium-teboroxime in the isolated rabbit heart [abstract]. J Am Coll Cardiol 1991; 17 (2 Suppl A): 286A.CrossRefGoogle Scholar
  20. 20.
    Okada RD, Johnson G3d, Glover DK, Hebert CB. Myocardial Tc-99m-teboroxime (Cardiotec, SQ30217) clearance is reduced in ischemic myocardium due to a combination of hypoxic and low flow factors [abstract]. J Am Coll Cardiol 1991; 17 (2 Suppl A): 286A.CrossRefGoogle Scholar
  21. 21.
    Taillefer R, Gagnon A, Laflamme L, Gregoire J, Leveille J, Phaneuf DC. Same day injections of Tc-99m methoxy isobutyl isonitrile (hexamibi) for myocardial tomographic imaging: comparison between rest-stress and stress-rest injection sequences. Eur J Nucl Med 1989; 15: 113–7.PubMedGoogle Scholar
  22. 22.
    Fleming RM, Kirkeeide RL, Taegtmeyer H, Adyanthaya A, Cassidy DB, Goldstein RA. Comparison of technetium-99m teboroxime tomography with automated quantitative coronary arteriography and thallium-201 tomographic imaging. J Am Coll Cardiol 1991; 17: 1297–302.PubMedCrossRefGoogle Scholar
  23. 23.
    Iskandrian AS, Heo J, Nguyen T, Mercuro J. Myocardial imaging with Tc-99m teboroxime: technique and initial results. Am Heart J 1991; 121: 889–94.PubMedCrossRefGoogle Scholar
  24. 24.
    Burns RJ, Wright L. Three-minute acquisition of exercise Tc-99m-teboroxime cardiac SPECT with a single-head detector [abstract]. J Nucl Med 1991; 32 Suppl: 929.Google Scholar
  25. 25.
    Friedman J, Van Train K, Maddahi J. ‘Upward creep’ of the heart: a frequent source of false-positive reversible defects during thallium-201 stress-redistribution SPECT. J Nucl Med 1989; 30: 1718–22.PubMedGoogle Scholar
  26. 26.
    Kim AS, Quaife RA, Akers MS, Faber TL, Corbett JR. Sequential tomographic myocardial perfusion imaging with Tc-99m teboroxime in patients: comparison with thallium-201 and arteriography [abstract]. J Nucl Med 1991; 32 Suppl: 919.Google Scholar
  27. 27.
    Drane WE, Decker M, Strickland P, Tineo A, Zmuda S. Measurement of regional myocardial perfusion using Tc-99m teboroxime (Cardiotec) and dynamic SPECT [abstract]. J Nucl Med 1989; 30: 1744.Google Scholar
  28. 28.
    Zielonka JS, Bellinger R, Coleman RE et al. Multicenter clinical trial of 99m-Tc teboroxime (SQ30217; Cardiotec) as a myocardial perfusion agent [abstract]. J Nucl Med 1989; 30:1745.Google Scholar
  29. 29.
    Zielonka JS, Cannon P, Johnson L et al. Multicenter trial of Tc-99m teboroxime (Cardiotec): a new myocardial perfusion agent [abstract]. J Nucl Med 1990; 31 Suppl: 827.Google Scholar
  30. 30.
    Taillefer R, Freeman M, Greenberg D et al. Detection of coronary artery disease: comparison between 99m-Tc-teboroxime and 201-thallium planar myocardial perfusion imaging (Canadian multicenter clinical trial) [abstract]. J Nucl Med 1991; 32 Suppl: 919.Google Scholar
  31. 31.
    Hendel RC, Dahlberg ST, McSherry BA, Leppo JA. Diagnostic correlation between rapid planar teboroxime imaging and thallium scintigraphy: general concordance and a comparison by vascular territory [abstract]. J Nucl Med 1990; 31 Suppl: 827–8.Google Scholar
  32. 32.
    Serafini AN, Friden A, Topchik S et al. Tomographic SPECT myocardial imaging — A comparative study between Tc-99m-teboroxime (teboroxime) and 201 thallium [abstract]. J Nucl Med 1991; 32 Suppl: 920.Google Scholar
  33. 33.
    Burns RJ, Fung A, Iles S, Daigneault L, Lalonde L, Hong Tai Eng F. Exercise Tc-99m-teboroxime cardiac SPECT: results of a Canadian multicenter trial [abstract]. J Nucl Med 1991; 32 Suppl: 919.Google Scholar
  34. 34.
    Nguyen T, Heo J, Beer S, Cassel D, Cave V, Iskandrian AS. SPECT teboroxime imaging during adenosine-induced coronary hyperemia [abstract]. J Nucl Med 1991; 32 Suppl: 1036.Google Scholar
  35. 35.
    Labonte C, Taillefer R, Lambert R et al. Comparison between Tc-99m-teboroxime and 201-thallium dipyridamole imaging in detection of coronary artery disease [abstract]. J Nucl Med 1991; 32 Suppl: 919–20.Google Scholar
  36. 36.
    Hendel RC, McSherry BA, Leppo JA. Teboroxime and thallium (with reinjection) scintigraphy for the detection of myocardial ischemia and infarction [abstract]. Circulation 1990; 82 (4 Suppl III): III320.Google Scholar
  37. 37.
    Dilsizian V, Rocco TP, Freedman NM, Leon MB, Bonow RO. Enhanced detection of ischemic but viable myocardium by the reinjection of thallium after stress-redistribution imaging. N Engl J Med 1990; 323: 141–6.PubMedCrossRefGoogle Scholar
  38. 38.
    Port S, Gal S, Grenier R, Acharya K, Shen Y, Skrade B. First-pass radionuclide angiography during treadmill exercise: evaluation of patient motion and a method for motion correction [abstract]. J Nucl Med 1989: 30 Suppl: 770.Google Scholar
  39. 39.
    Wackers FJ, Gibbons RJ, Verani MS et al. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: efficacy for noninvasive assessment of thrombolytic therapy. J Am Coll Cardiol 1989; 14: 861–73.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • Robert C. Hendel

There are no affiliations available

Personalised recommendations