Abstract
It is almost 15 years since it was suggested that, in the field of myocardial perfusion imaging, the use of a technetium-99m (Tc-99m) based agent could significantly improve image quality as a result of a two-fold increase in resolution and up to four-fold increase in the administered dose compared to the established agent of choice thallous (Tl-201) chloride [1]. In fact, Tc-99m agents that have been developed since those original estimates were made, have even better dosimetry characteristics than predicted. It has, however, taken a considerable amount of effort by numerous research groups to reach the present stage in which several commercially produced Tc-99m myocardial perfusion imaging agents are either already licensed or nearing licence approval.
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Higley, B., Lahiri, A., Kelly, J.D. (1992). Technetium-99m complexes of functionalized diphosphines for myocardial perfusion imaging in man. In: van der Wall, E.E., Sochor, H., Righetti, A., Niemeyer, M.G. (eds) What’s New in Cardiac Imaging?. Developments in Cardiovascular Medicine, vol 133. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2456-0_8
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DOI: https://doi.org/10.1007/978-94-011-2456-0_8
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