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Assessment of myocardial fatty acid metabolism with carbon-11 palmitate

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Book cover What’s New in Cardiac Imaging?

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 133))

Abstract

The positron emitting radionuclide carbon-11 allows the labeling of fatty acids without alteration to their molecular structure. Accordingly, the labeled fatty acid is taken up by the myocardium and metabolized in proportion to the unlabeled circulating counterpart. The availability of a true tracer of fatty acid metabolism combined with the quantitative capabilities positron imaging represent the framework for the noninvasive assessment of regional fatty acid metabolism with positron emission tomography (PET) [1-3]. Furthermore, the short half-life of carbon-11 (half-life 20.4 minutes) enables sequential evaluation of metabolism which is important if the method is used to study transient metabolic alterations or to monitor the effect of a therapeutic intervention on regional metabolism. These advantages of PET over the approaches using single photon emitting radioiodinated fatty acids have to be weighed against the higher costs involved in both the logistics required for on-site cyclotron-production of short-lived isotopes and the ensuing radiochemistry.

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Authors
  1. René Lerch
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Editor information

Editors and Affiliations

  1. Department of Cardiology, University Hospital Leiden, Building 1, C5-P25 Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    Ernst E. van der Wall

  2. Department of Cardiology, University of Vienna, Garnisongasse 13, A-1090, Vienna, Austria

    Heinz Sochor

  3. Department of Cardiology, Hôpital Cantonal Universitaire, CH-1211, Geneva, Switzerland

    Alberto Righetti

  4. Department of Nuclear Medicine, University Hospital Leiden, Building 1, C4-Q-80 Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    Menco G. Niemeyer

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© 1992 Springer Science+Business Media Dordrecht

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Lerch, R. (1992). Assessment of myocardial fatty acid metabolism with carbon-11 palmitate. In: van der Wall, E.E., Sochor, H., Righetti, A., Niemeyer, M.G. (eds) What’s New in Cardiac Imaging?. Developments in Cardiovascular Medicine, vol 133. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2456-0_18

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  • DOI: https://doi.org/10.1007/978-94-011-2456-0_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5083-8

  • Online ISBN: 978-94-011-2456-0

  • eBook Packages: Springer Book Archive

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