Advertisement

Assessment of myocardial metabolism in vivo: a biochemist’s view

  • Arnoud van der Laarse
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 133)

Summary

Due to extensive biochemical investigations on myocardial tissue during the last 50 years and the recent development of techniques (positron emission tomography, magnetic resonance imaging, magnetic resonance spectroscopy, single photon emission computed tomography) to visualize and/or quantify biochemical parameters in the human heart in vivo, the era of metabolic imaging has begun. In addition to imaging of metabolic substrates and intermediates (palmitate, glucose, ATP, phosphocreatine) future contributions regarding receptor-effector-second messenger functions will augment our understanding of normal myocardial metabolism and its regulation, but particularly of their abnormalities in cardiac diseases.

Keywords

Positron Emission Tomography Single Photon Emission Compute Tomography Myocardial Metabolism Metabolic Imaging Free Fatty Acid Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bolli R. Mechanism of myocardial’ stunning’. Circulation 1990; 82: 723–38.Google Scholar
  2. 2.
    Ito BR, Tate H, Kobayashi M, Schaper W. Reversibly inj ured, postischemic canine myocardium retains normal contractile reserve. Circ Res 1987; 61: 834–46.Google Scholar
  3. 3.
    Moore EDW, Becker PL, Fogarty KE, Williams DA, Fay FS. Ca2+ imaging in single living cells: theoretical and practical issues. Cell Calcium 1990; 11: 157–79.Google Scholar
  4. 4.
    Kusuoka H, Koretsune Y, Chacko VP, Weisfeldt ML, Marban E. Excitation-contraction coupling in postischemic myocardium. Does failure of activator Ca2+ transients underlie stunning? Circ Res 1990; 66: 1268–76.Google Scholar
  5. 5.
    Schelbert HR, Buxton D. Insights into coronary artery disease from metabolic imaging. Circulation 1988; 78: 496–505.Google Scholar
  6. 6.
    Keller AM, Sorce DJ, Sciacca RR, Barr ML, Cannon PJ. Very rapid lactate measurement in ischemic perfused hearts using 1H MRS continuous negative echo acquisition during steadystate frequency selective excitation. Magn Reson Med 1988; 7: 65–78.PubMedCrossRefGoogle Scholar
  7. 7.
    Cannon PJ, Maudsley AA, Hilal SK, Simon HE, Cassidy F. Sodium nuclear magnetic resonance imaging of myocardial tissue of dogs after coronary artery occlusion and reperfusion. J Am Coll Cardiol 1986; 7: 573–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Borgers M. Morphology of human hibernating myocardium [abstract]. J Mol Cell Cardiol 1991;23(suppl V):S12.CrossRefGoogle Scholar
  9. 9.
    Vatner SF, Shannon R, Hittinger L.Reduced subendocardial coronary reserve. A potential mechanism for impaired diastolic function in the hypertrophied and failing heart. Circulation 1990; 81(suppl III): III–8–III–14.Google Scholar
  10. 10.
    Anderson PG, Allard MF, Thomas GD, Bishop SP, Digerness SB. Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts. Circ Res 1990; 67: 948–59.PubMedCrossRefGoogle Scholar
  11. 11.
    Kagaya Y, Kanno Y, Takeyama D et al. Effects of long-term pressure overload on regional myocardial glucose and free fatty acid uptake in rats. A quantitative autoradiographic study. Circulation 1990; 81: 1353–61.Google Scholar
  12. 12.
    Miller DD, Walsh RA. In vivo phosphorus-31 NMR spectroscopy of abnormal myocardial high-energy phosphate metabolism during cardiac stress in hypertensive-hypertrophied nonhuman primates. Int J Card Imag 1990/91; 6: 57–70.CrossRefGoogle Scholar
  13. 13.
    Parmacek MS, Magid LM, Lesch M, Decker RS, Samarel AM. Cardiac protein synthesis and degradation during thyroxine-induced left ventricular hypertrophy. Am J Physiol 1986; 251: C727–36.Google Scholar
  14. 14.
    Schofer J, Spielmann R, Schuchert A et al. Iodine-123 metaiodobenzylguanidine scintigraphy. A noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 1988; 12: 1252–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • Arnoud van der Laarse

There are no affiliations available

Personalised recommendations