Assessment of myocardial metabolism in vivo: a biochemist’s view
Due to extensive biochemical investigations on myocardial tissue during the last 50 years and the recent development of techniques (positron emission tomography, magnetic resonance imaging, magnetic resonance spectroscopy, single photon emission computed tomography) to visualize and/or quantify biochemical parameters in the human heart in vivo, the era of metabolic imaging has begun. In addition to imaging of metabolic substrates and intermediates (palmitate, glucose, ATP, phosphocreatine) future contributions regarding receptor-effector-second messenger functions will augment our understanding of normal myocardial metabolism and its regulation, but particularly of their abnormalities in cardiac diseases.
KeywordsPositron Emission Tomography Single Photon Emission Compute Tomography Myocardial Metabolism Metabolic Imaging Free Fatty Acid Uptake
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