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Myocardial perfusion imaging with copper-62 labeled Cu-PTSM

  • Mark A. Green
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 133)

Abstract

The value of positron emission tomography (PET) in the study of myocardial physiology and the clinical diagnosis of cardiac disease is widely recognized. The short-lived radionuclides most commonly used as labels for PET radiopharmaceuticals are 15O,13N, 11C, and 18F. These have proven particularly useful because they allow natural biochemical substrates to be labeled by isotopic substitution for tracer studies of a diversity of discrete physiological processes. Unfortunately, the short half-lives of these radionuclides (2,10,20, and 110 minutes, respectively) pose problems with regard to isotope production and delivery. Hospitals that employ 15O, 13N, 11C, and 18F radiopharmaceuticals will generally find it necessary to operate an in-house cyclotron facility for radionuclide production, since only 18F is sufficiently long-lived to allow remote production for distribution via a regional delivery system. For many hospitals, the expense of operating a cyclotron for radionuclide production presents a barrier to the use of PET in clinical diagnosis.

Keywords

Positron Emission Tomography Myocardial Perfusion Myocardial Perfusion Imaging Positron Emission Tomography Study Positron Emission Tomography Tracer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • Mark A. Green

There are no affiliations available

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