Probiotics pp 225-257 | Cite as

Probiotics for chickens

  • Paul A. Barrow


As with other animals, the development of probiotics for poultry has developed out of our increasing understanding of the microflora of the alimentary tract. Although Pasteur’s observations suggested that the host and its intestinal microflora were interdependent, the intellectual origins of probiosis started with Metchnikoff (1907). He thought that, on balance, the intestinal microflora was detrimental to the host because of absorption of toxic bacterial metabolites. By correlating the longevity of some of the rural inhabitants of the Caucasus with their ingestion of fermented milk throughout their life, he suggested that health status and longevity could be improved by consumption of milks fermented by lactobacilli.


Lactic Acid Bacterium Alimentary Tract Competitive Exclusion Intestinal Flora Lactobacillus Acidophilus 
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  1. Adler, H.E. and DaMassa, A.J. (1980) Effects of ingested lactobacilli on Salmonella infantis and Escherichia coli and on intestinal flora, pasted vents and chick growth. Avian Dis., 24, 868–78.CrossRefGoogle Scholar
  2. Arends, L.G. (1981) Influence of L. acidophilus administered via the drinking water on broiler performance. Poultry Sci., 60, 1617 (Abstract).Google Scholar
  3. Balish, E. and Phillips, A.W. (1966) Growth and virulence of Candida albicans after oral inoculation in the chick with a monoflora of either Escherichia coli or Streptococcus faecalis. J. Bacteriol., 91, 1744–9.Google Scholar
  4. Barnes, E.M., Impey, C.S. and Cooper, D.M. (1980) Competitive exclusion of salmonellae from the newly hatched chick. Vet. Record, 160, 61.CrossRefGoogle Scholar
  5. Barrow, P.A. (1987) Microbial antibiotic resistance in animals, in Combating Resistance to Xenobiotics (eds M.G Ford et al.), Ellis Horwood, Chichester, UK.Google Scholar
  6. Barrow, P.A. (1991) Immunological control of Salmonella in poultry. Proc. Tnt. Symp. on Control of Human Bacterial Pathogens in Poultry, Atlanta, Georgia, USA pp. 199–217.Google Scholar
  7. Barrow, P.A., Simpson, J.M. and Lovell, M.A. (1988) Intestinal colonization on the chicken by food-poisoning Salmonella serotypes; microbial characteristics associated with faecal excretion. Avian Pathol., 17, 571–88.CrossRefGoogle Scholar
  8. Barrow, P.A. and Tucker, J.F. (1986) Inhibition of colonization of the chicken with Salmonella typhimurium by pre-treatment with strains of Escherichia coli. J. Hygiene. (Camb.), 96, 161–9.CrossRefGoogle Scholar
  9. Barrow, P.A., Tucker, J.F. and Simpson, J.M. (1987) Inhibition of colonization of the chicken alimentary tract with Salmonella typhimurium by Gramnegative facultatively anaerobic bacteria. J. Hygiene (Camb.), 98, 311–22.Google Scholar
  10. Beach, J.R. and Davis, D.E. (1925) The influence of feeding lactose or dry skim milk on artificial infection of chicks with Eimeria avium. Hilgardia, 1, 167–81.Google Scholar
  11. Berchieri, A. Jr and Barrow, P.A. (1990) Further studies on the inhibition of colonization of the chicken alimentary tract with Salmonella typhimurium by pre-colonization with an avirulent mutant. Epidemiol. Infect., 104, 427–41.CrossRefGoogle Scholar
  12. Berchieri, A. Jr, Lovell, M.A. and Barrow, P.A. (1991) The activity in the chicken alimentary tract of bacteriophages lytic for Salmonella typhimurium. Res. Microbiol. 142, 541–9.CrossRefGoogle Scholar
  13. Blaxland, J.D. and Fincham, I.H. (1950) Mycosis of the crop (moniliasis) in poultry, with particular reference to serious mortality occurring in young turkeys. Brit. Vet. J., 106, 221–31.Google Scholar
  14. Bohnhoff, M., Drake, B.L. and Miller, C.P. (1954) Effect of streptomycin on susceptibility of the intestinal tract to experimental salmonella infection. Proc. Soc. Exp. Biol. Med., 86, 132–7.Google Scholar
  15. Brooker, B.E. and Fuller, R (1975) Adhesion of lactobacilli to the chicken crop epithelium. J. Ultrastruet. Res., 52, 21–31.CrossRefGoogle Scholar
  16. Buenrostro, J.L. and Kratzer, F.H. (1983) Effects of Lactobacillus inoculation and antibiotic feeding of chickens on availability of dietary biotin. Poultry Sci., 62, 2022–9.CrossRefGoogle Scholar
  17. Burkett, R.F., Thayer, R.H. and Morrison, R.D. (1977) Supplementing market broiler rations with lactobacillus and live yeast cultures. Animal Science Agricultural Research Report, Oklahoma State University and USDA, USA.Google Scholar
  18. Cerniglia, G.J., Goodling, A.C. and Herbert, J.A. (1983) The response of layers to feeding lactobacillus fermentation products. Poultry Sci., 62, 1399. (Abstract)CrossRefGoogle Scholar
  19. Charles, O.W. and Duke, S. (1978) The response of laying hens to dietary fermentation products and probiotic-antibiotic combinations. Poultry Sci., 57, 1125. (Abstract)Google Scholar
  20. Coates, M.E., Ford, J.E. and Harrison, G.F. (1968) Intestinal synthesis of vitamins of the B complex in chicks. Brit. J. Nutr., 22, 493–500.CrossRefGoogle Scholar
  21. Couch, J.R (1978) Poultry researchers outline benefits of bacteria, fungistatic compounds, other feed additives. Feedstuffs 50, 6.Google Scholar
  22. Crawford, J.S. (1979) ‘Probiotics’ in animal nutrition. Proc. 1979 Arkansas Nutrition Conf., pp. 45–55.Google Scholar
  23. Damron, B.L., Wilson, H.R, Voitle, R.A. and Harms, R.H. (1981) A mixed lactobacillus culture in the diet of Broad Breasted Large White turkey hens. Poultry Sci., 60, 1350–1.CrossRefGoogle Scholar
  24. DeLoach, J.R, Oyofo, B.A., Corrier, D.E., Kubena, L.F., Ziprin, R.L. and Norman, J.O. (1990) Reduction of Salmonella typhimurium in broiler chickens by milk or whey. Avian Dis., 34, 389–92.CrossRefGoogle Scholar
  25. Dilworth, B.C. and Day, E.J. (1978) Lactobacillus cultures in broiler diets. Poultry Sci., 57, 1101 (Abstract).Google Scholar
  26. Dubos, R, Schaedler, R.W., Costello, R. and Hoet, P. (1965) Indigenous, normal and autochthonous flora of the gastrointestinal tract. J. Exp. Med., 122; 67–76.CrossRefGoogle Scholar
  27. Duval-Iflah, Y., Chappuis, J.P., Ducluzeau, R. and Raibaud, P. (1983) Intraspecific interactions between Escherichia coli in human newborns and in gnotobiotic mice and piglets. Prog. Food Nutr. Sci., 7, 107–16.Google Scholar
  28. Eyssen, H. and DeSomer, P. (1967) Effects of Streptococcus faecalis and a filterable agent on growth and nutrient absorption in gnotobiotic chicks. Brit. Poultry Sci., 46, 323–33.CrossRefGoogle Scholar
  29. Eyssen, H., Swaelen, K, Kowszyk-Gindifer, Z. and Parmenteer, G. (1965) Nucleotide requirements of Lactobacillus acidophilus variants isolated from the crops of chicks. Antonie van Leeuwenhoek, 31, 241.CrossRefGoogle Scholar
  30. Fethiere, R. and Miles, R.D. (1987) Intestinal tract weight of chicks fed an antibiotic and probiotic. Nutr. Rept Int., 36, 1305–9.Google Scholar
  31. Ford, D.J. (1974) The effect ofthe microflora on gastrointestinal pH in the chick. Brit. Poultry Sci., 15, 131–40.CrossRefGoogle Scholar
  32. Francis, C., Janky, D.M., Arafa, A.S. and Harms, R.H. (1978) Interrelationship of lactobacillus and zinc bacitracin in the diets of turkey poults. Poultry Sci., 57, 1687–9.CrossRefGoogle Scholar
  33. Fuller, R (1973) Ecological studies on the lactobacillus flora associated with the crop epithelium of the fowl. J. Appl. Baeteriol., 36, 131–9.CrossRefGoogle Scholar
  34. Fuller, R (1975) Nature of the determinant responsible for the adhesion of lactobacilli to chicken crop epithelial cells. J. Gen. Microbiol., 87, 245–50.CrossRefGoogle Scholar
  35. Fuller, R (1977) The importance of lactobacilli in maintaining normal microbial balance in the crop. Poultry Sci., 18, 85–94.CrossRefGoogle Scholar
  36. Fuller, R (1978) Epithelial attachment and other factors controlling the colonization of the intestine of the gnotobiotic chicken by lactobacilli. J. Appl. Bacteriol., 45, 389–95.CrossRefGoogle Scholar
  37. Fuller, R (1986) Probiotics. J. Appl. Bacteriol. Symp., No. 15, pp. 1–7.Google Scholar
  38. Fuller, R. and Moore, J.H. (1967) The inhibition of the growth of Clostridium welehii by lipids isolated from the content of the small intestine of the pig. J. Gen. Microbiol., 46, 23–41.CrossRefGoogle Scholar
  39. Fuller, R. and Turvey, A. (1971) Bacteria associated with the intestinal wall of the fowl (Gallus domesticus). J. Appl. Bacteriol., 34, 617–22.CrossRefGoogle Scholar
  40. Fuller, R. Coates, M.K. and Harrison, G.F. (1979) The influence of specific bacteria and a filterable agent on the growth of gnotobiotic chicks. J. Appl. Bacteriol., 46, 335–42.CrossRefGoogle Scholar
  41. Fuller, R. Houghton, S.B. and Brooker, B.K. (1981) Attachment of Streptococcus faecium to the duodenal epithelium of the chicken and its importance in colonization of the small intestine. Appl. Environ. Microbiol., 41, 1433–41.Google Scholar
  42. Gilliland, S.K. and Speck, M.L. (1977) Antagonistic action of Lactobacillus acidophilus toward intestinal and foodborne pathogens in associative culture. J. Food Protect., 40, 820–3.Google Scholar
  43. Goren, K (1982) Unpublished data cited by Pivnick, H. and Nurmi, K The Nurmi concept and its role in the control of Salmonella in poultry. Devel. Food Microbiol., 1, 41–70.Google Scholar
  44. Hamdan, L.Y. and Mikolaicik, K.M. (1974) Acidolin: an antibiotic produced by Lactobacillus acidophilus. J. Antibiot., 27, 632–6.CrossRefGoogle Scholar
  45. Hinton, M., Linton, A.H. and Perry, F.G. (1985) Control of Salmonella by acid disinfection of chick’s food. Vet. Record, 116, 502.CrossRefGoogle Scholar
  46. Houghton, S.B. and Fuller, R (1980) Ecology of Streptococcus faecium bacteriophage in chicken gut. Appl. Environ. Microbiol., 39, 1054–8.Google Scholar
  47. Houghton, S.B., Fuller, R. and Coates, M.K. (1981) Correlation of growth depression of chicks with the presence of Streptococcus faecium in the gut. J. Appl. Bacteriol., 51, 113–20.CrossRefGoogle Scholar
  48. Impey, C.S., Mead, G.C. and George, S.M. (1982). Competitive exclusion of Salmonellas from the chicken caecum using a defined mixture of bacterial isolates from the caecal microflora of the adult bird. J. Hygiene, (Camb.) 89, 479–490.CrossRefGoogle Scholar
  49. Jernigan, M.A., Miles, R.D. and Arafa, A.S. (1985) Probiotics in poultry nutrition-a review. Worlds Poultry Sci. J., 41, 99–107.CrossRefGoogle Scholar
  50. Krueger, W.F., Bradley, J. W. and Patterson, R.H. (1977) The interaction of gentian violet and lactobacillus organisms in the diet of Leghorn hens. Poultry Sci., 56, 1729. (Abstract)CrossRefGoogle Scholar
  51. Lev, M. and Forbes, M. (1959) Growth response to dietary penicillin of germ-free chicks and of chicks with a defined intestinal flora. Brit. J. Nutr., 13, 78–84.CrossRefGoogle Scholar
  52. Unton, A.H., Howe, K., Richmond, M.H. et al. (1978) Attempts to displace the indigenous antibiotic resistant gut flora of chickens by feeding sensitive strains of Escherichia coli prior to slaughter. J. Appl. Bacteriol., 45, 239–47.CrossRefGoogle Scholar
  53. Mead, G.C. (1989) Microbes of the avian caecum; types present and substrates utilized. J. Exp. Zool. Supp., 3, 48–54.CrossRefGoogle Scholar
  54. Mead, G.C. and Barrow, P.A. (1990) Salmonella control in poultry by competitive exclusion or immunization. Lett. Appl. Microbiol., 10, 221–7.CrossRefGoogle Scholar
  55. Mead, G.C. and Impey, C.S. (1987) The present status of the Nurmi concept for reducing carriage of food-poisoning salmonellae and other pathogens in live poultry, (ed. F.J.M. Smulders) in Elimination of Pathogenic Organisms from Meat and Poultry, Elsevier, Amsterdam.Google Scholar
  56. Metchnikoff, E. (1907) The Prolongation of Life. Heinemann, London.Google Scholar
  57. Miles, R.D., Arafa, A.S., Harms, R.H. et al. (1981a) Effects of a living non-freeze dried Lactobacillus acidophilus culture on performance, egg quality and gut microflora in commercial layers. Poultry Sci., 60, 993–1004.CrossRefGoogle Scholar
  58. Miles, R.D., Wilson, H.R, Arafa, A.S. et al. (1981b) The performance of Bobwhite quail fed diets containing lactobacillus. Poultry Sci., 60, 894–6.CrossRefGoogle Scholar
  59. Miles, R.D., Wilson, H.R. and Ingram, D.R (1981c) Productive performance of Bobwhite quail fed a diet containing a lactobacillus culture. Poultry Sci., 60, 1581-2.Google Scholar
  60. Morishita, Y., Mitsuoka, T., Kaneuchi, C. et al. (1971) Specific establishment of lactobacilli in the digestive tract of germfree chickens. Jap. J. Microbiol., 15, 531–8.Google Scholar
  61. Mulder, R.W.A.W. (1980) Control of salmonellae in poultry feed., in Proc. 6th European Poultry Congress, Hamburg.Google Scholar
  62. Niemen, C. (1954) Influence of trace amounts of fatty acids on the growth of microorganisms. Bacteriol. Rev., 18, 147–63.Google Scholar
  63. Nurmi, E. (1985). Use of competitive exclusion in prevention of Salmonellae and other enteropathogenic bacterial infections in poultry. In: (Rd. G.H. Snoeyenbos. Proceedings of the International Symposium on Salmonella, New Orleans. American Association of Avian Pathologists, University of Pennsylvania, pp. 64–71.Google Scholar
  64. Nurmi, E. and Rantala, M. (1973) New aspects of Salmonella infection in broiler production. Nature, London, 241, 210–11.CrossRefGoogle Scholar
  65. Oyofo, B.A., DeLoach, J.R, Corrier, D.E., et al. (1989a) Effect of carbohydrates on Salmonella typhimurium colonization in broiler chickens. Avian Dis., 33, 531–4.CrossRefGoogle Scholar
  66. Oyofo, B.A., DeLoach, J.R, Corrier, D.E. et al. (1989b) Prevention of Salmonella typhimurium colonization of broilers with D-mannose. Poultry Sci., 68, 1357–60.CrossRefGoogle Scholar
  67. Perdigón, G. (1991) Probiotics and the immune state (this volume).Google Scholar
  68. Pivnick, H. and Blanchfield, B. (1982) Unpublished data cited by Pivnick, H. and Nurmi, E. The Nurmi concept and its role in the control of Salmonella in poultry. Devel. Food Microbiol., 1, 41–70.Google Scholar
  69. Pivnick, H. and Nurmi, E. (1982) The Nurmi concept and its role in the control of Salmonellae in poultry, in Developments in Food Microbiology 1 (ed. R Davies). Applied Science Publishers, London, pp. 41–70.Google Scholar
  70. Pivnyak, L.G. and Konyakhin, A.N. (1973) Biologicheskaya effecktivnost preparatov iz zhivykh karotinoo brazuyushchikh kultur dlya tsplyat. Cited in Nutritional Abstracts and Reviews 43, 330.Google Scholar
  71. Potter, L.M., Newbem, L.A., Parsons, C.M., et al. (1979) Effects of protein, poultry by-product meal and dry Lactobacillus acidophilus culture additions to diets of growing turkeys. Poultry Sci., 58, 1095. (Abstract)CrossRefGoogle Scholar
  72. Rigby, C., Pettit, J. and Robertson, A. (1977) The effects of normal intestinal flora on the salmonella carrier state, in Proc. Int. Symp. on Salmonella and Prospects for Control, Guelph, Ontario, Canada, (ed. D.A. Bamum).Google Scholar
  73. Rubin, H.E. & Vaughan, F. (1979). Elucidation of the inhibitory factors of yogurt against Salmonella typhimurium. J. Dairy Sci., 62, 1873.CrossRefGoogle Scholar
  74. Rubin, H.E., Nerad, T. and Vaughan, F. (1982) Lactic acid inhibition of Salmonella typhimurium in yogurt. J. Dairy Sci., 65, 197–203.CrossRefGoogle Scholar
  75. Schmidt, G.P., Domermuth, C.H. and Potter, L.M. (1988) Effect of oral Escherichia coli inoculation on performance of young turkeys. Avian Dis., 32, 103–7.CrossRefGoogle Scholar
  76. Shahani, K.M., Vakil, J.R and Kilara, A. (1977) Natural antibiotic activity of Lactobacillus acidophilus and bulgaricus. II. Isolation of acidophilin from L. acidophilus. Cult. Dairy Prod.J., 12, 8–11.Google Scholar
  77. Siccardi, F.J. and Pomeroy, B.S. (1964) Effect of E. coli on the growth rate, morbidity and mortality in monocontaminated and conventional white rock chickens. Poultry Sci., 43, 1361 (Abstract).Google Scholar
  78. Smith, H.W. (1965a) The development of the flora of the alimentary tract in young animals. J. Pathol. Bacteriol., 90, 495–513.CrossRefGoogle Scholar
  79. Smith, H.W. (1965b) Observations on the flora of the alimentary tract of animals and factors affecting its composition. J. Pathol. Bacteriol., 89, 95–122.CrossRefGoogle Scholar
  80. Smith, H.W. and Huggins, M.B. (1982) Successful treatment of experimental Escherichia coli infections in mice using phage; its general superiority over antibiotics. J. Gen. Microbiol., 128, 307–18.Google Scholar
  81. Smith, H.W. and Huggins, M.B. (1983) Effectiveness of phages in treating experimental Escherichia coli diarrhoea in calves, piglets and lambs. J. Gen. Microbiol., 129, 2659–75.Google Scholar
  82. Smith, H.W., Barrow, P.A. and Tucker, J.F. (1985) The effect of oral antibiotics administration on the excretion of Salmonellae by chickens, in Proc. Int. Symp. of Salmonella, New Orleans, USA (ed. G.N. Snoeyenbos).Google Scholar
  83. Soerjadi, A.S., Lloyd, A.B. and Cumming, R.B. (1978) Streptococcus faecalis, a bacterial isolate which protectS young chickens from enteric invasion by salmonellae. Austral. Vet. J., 54, 549–50.CrossRefGoogle Scholar
  84. Soerjadi, A.S., Steham, S.M., Snoeyenbos, G.H., et al. (1981) The influence of lactobacilli on the competitive exclusion of paratyphoid salmonellae in chickens. Avian Dis., 25, 1027–33.CrossRefGoogle Scholar
  85. Stavric, S., Gleeson, T.M., Blanchfield, B. & Plinick, R. (1983). Competitive exclusion of Salmonella from newly hatched chicks by mixtures of pure bacterial cultures isolated from faeces and caecal contents of adult birds. J. Food Protect., 48, 778–782.Google Scholar
  86. Tortuero, F. (1973) Influence of implantation of Lactobacillus acidophilus in chicks on the growth, feed conversion, malabsorption of fats syndrome and intestinal flora. Poultry Sci., 52, 197–203.CrossRefGoogle Scholar
  87. Watkins, B.A., Miller, B.F. and Neil, D.H. (1982) In vivo effects of Lactobacillus acidophilus against pathogenic Escherichia coli in gnotobiotic chicks. Poultry Sci., 61, 1298–1308.CrossRefGoogle Scholar
  88. Watkins, B.A. and Miller, B.F. (1983) Competitive gut exclusion of avian pathogens by Lactobacillus acidophilus in gnotobiotic chicks. Poultry Sci., 62, 1772–9.CrossRefGoogle Scholar
  89. Watkins, B.A. and Kratzer, F.H. (1983a) Effect of oral dosing of Lactobacillus strains on gut colonization and liver biotin in broiler chicks. Poultry Sci., 62, 2088–94.CrossRefGoogle Scholar
  90. Watkins, B.A. and Kratzer, F.H. (1983b) Drinking water treatment with a commercial preparation of a concentrated Lactobacillus culture for broiler chickens. Poultry Sci., 63, 1671–3.CrossRefGoogle Scholar
  91. Wheater, D.M., Hirsch, A. and Mattick, A.T.R. (1952) Possible identity of ‘Lactobacillin’ with hydrogen peroxide produced by lactobacilli. Nature, 170, 623.CrossRefGoogle Scholar
  92. Wilson, G.S. and Miles, A.A. (1973) Topley and Wilson’s Principles of Bacteriology and Immunity, 6th edn,. Edward Arnold, London.Google Scholar

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© Springer Science+Business Media Dordrecht 1992

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  • Paul A. Barrow

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