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Epithelial Organization and Development pp 273–298Cite as

The role of yolk sac and gut epithelial cells in maternal immunoglobulin transport

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Abstract

Epithelial cells are not often thought of as being adapted for vectorial transport of intact macromolecules from an apical (luminal) to a basal (serosal) compartment, but in certain situations this is a prerequisite for survival. For instance, all mammals acquire maternal antibodies, either from the mother’s blood or uterine fluid during their development in utero or from the colostrum and milk when suckling commences. Such antibodies provide the foetus and/or newly born mammal with passive immunity, giving it immediate protection against infective agents to which the mother has previously been exposed, and until such time as its own developing immune system has learnt to respond fully to antigenic stimuli. Depending upon the species concerned and whether transport occurs pre- or postnatally, different organs have to be traversed by maternal antibodies. These are the yolk sac splanchnopleure (YSS; as in rabbit, guinea pig and to some extent rodents), the chorio-allantoic placenta (as in human and rhesus monkey), and the gut (as in ruminants, pigs, horses, marsupials and rodents). The epithelial cells which in part constitute these organs and which play a primary role in the transport process are the yolk sac endoderm (YSE), syncytiotrophoblast, and gut enterocytes, respectively. Birds also acquire maternal passive immunity.

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  1. Department of Biology, University of Southampton, UK

    Arthur E. Wild

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  1. Department of Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO9 3TU, UK

    Tom P. Fleming

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Wild, A.E. (1992). The role of yolk sac and gut epithelial cells in maternal immunoglobulin transport. In: Fleming, T.P. (eds) Epithelial Organization and Development. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2354-9_10

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