Abstract
The ability to learn from experience is an essential survival tool, and it is reasonable to suppose that the molecular mechanisms required for learning developed early in evolution. Consequently it is probable that some of these mechanisms were conserved as species multiplied and diversified into the available ecological niches. The acceptance of this argument allows us to study the cellular substrates of memory in accessible animal models, and to extrapolate from the animal model to human memory with some confidence. However, convergent evolution of organ function is well established. Because learning and memory are operational definitions, and in the strict sense do not exist unless an appropriate behavioural change occurs, evolutionary convergence of function remains a pitfall for attempts to generalize molecular mechanisms of learning.
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References
Alkon, D.L. (1980) Cellular analysis of a gastropod (Hermissenda crassicornis) model of associative learning. Biol. Bull, 159, 505–60.
Alkon, D.L. (1982) Regenerative changes of voltage-dependent Ca2+ and K+ currents encode a learned stimulus association. J. Physiol (Paris.), 78, 700–6.
Alkon, D.L. (1987) Memory traces in the brain. Cambridge: Cambridge University Press.
Alkon, D.L., Farley, J., Sakakibara, M., et al. (1984) Voltage-dependent calcium and calcium-activated potassium currents of a molluscan photoreceptor. Biophys. J., 46, 605–14.
Alkon, D.L., Sakakibara, M., Forman, R., et al. (1985) Reduction of two voltage-dependent K+ currents mediates retention of a learned association. Behav. Neural. Biol., 44,278–300.
Alkon, D.L., Kubota, M., Neary, J.T., et al. (1986) C-kinase activation prolongs Ca2+-dependent inactivation of K+ currents. Biochem. Biophys. Res. Commun., 134, 1245–53.
Alkon, D.L., Naito, S., Kubota, M., et al. (1988) Regulation of Hermissenda K+ channels by cytoplasmic and membrane-associated C-kinase. J. Neurochem., 51, 903–17.
Castagna, M., Takai, Y., Kaibuchi, K., et al. (1982) Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem., 257, 7847–51.
Castellucci, V. and Kandel, E.R. (1976) Presynaptic facilitation as a mechanism for behavioural sensitization in Aplysia. Science, 194, 1176–8.
Clark, R.B. (1960) Habituation of the polychaete Nereis to sudden stimuli. 1. General properties of the habituation process. Anim. Behav., 8, 82–91.
Collin, C., Ikeno, H., Harrigan, J.F., et al. (1988) Sequential modification of membrane currents with classical conditioning. Biophys. J., 54, 955–60.
Collin, C., Papageorge, A.G., Sakakibara, M., et al. (1990) Regulation of membrane excitability by ras oncognene proteins. Biophys. J., 984, 785–90.
Cote, R.H., Nicol, G.D., Burke, S.A., et al. (1991) Cyclic GMP levels and membrane current during onset, recovery and light adaptation of the photo-response of detached frog photoreceptors. J. Biol. Chem., 264, 15384–91.
Crow, T.J. and Alkon, D.L. (1978) Retention of an associative behavioural change in Hermissenda. Science, 201, 1239–41.
Davis, H.P. and Squire, L.R. (1984) Protein synthesis and memory: a review. Psychol. Bull., 96, 518–59.
Edelman, A.M., Blumenthal, B.K. and Krebs, E.G. (1987) Protein serine/ threonine kinases. Ann. Rev. Biochem., 56, 567–613.
Epand, R.M. and Lester, D.S. (1990) The role of membrane biophysical properties in the regulation of protein kinase C activity. Trend Pharm. Sci., 11, 317–20.
Farley, J., Richards, W.G., Ling, L.J., et al. (1983) Membrane changes in a single photoreceptor cause associative learning in Hermissenda. Science, 221, 1201–3.
Goelet, P., Castellucci, V.F., Schacher, S., et al. (1986) The long and the short of long-term memory — a molecular framework. Nature, 322, 419–22.
Goh, J.W. and Pennefather, P.S. (1989) A pertussis toxin-sensitive G protein in hippocampal long-term potentiation. Science, 244, 980–3.
Heldman, E., Grossman, Y., Jerussi, T.P., et al. (1979) Cholinergic features of photoreceptor synapses in Hermissenda. J. Neurophysiol., 42, 153–65.
Hingorani, V.N., Tobias, D.T., Henderson, J.T., et al. (1988) Chemical cross-linking of bovine retinal transducin and cGMP phosphodiesterase. J. Biol. Chem., 263, 6919–26.
Huddie, P.L. and Alkon, D.L. (1991) Cellular memory. In: Dulbeco, R. (ed) Encyclopaedia of Human Biology, vol. 2, 305–20.
Kaczmarek, L. (1991) The role of protein kinase C in the regulation of ion channels and neurotransmitter release. Trend Neurosci., 10, 30–4.
Lederhendler, I.I. and Alkon, D.L. (1987) Associatively reduced withdrawal from shadows in Hermissenda: a direct behavioural analog of photoreceptor responses to brief light steps. Behav. Neurol. Biol., 47, 227–49.
Lederhendler, I.I., Gart, S. and Alkon, D.L. (1986) Classical conditioning of Hermissenda: origin of a new response. J. Neurosci., 6, 1325–31.
Lester, D.S. and Alkon, D.L. (1991) Activation of protein kinase C phosphorylation pathways: a role for storage of associative memory. Prog. Brain Res. (in press).
Lester, D.S., Orr, N. and Brumfeld, V. (1990) Structural distinction between soluble and particulate protein kinase C species. J. Prot. Chem., 9, 209–20.
Mackintosh, N.J. (1983) Conditioning and associative learning. London: Oxford University Press.
Matzel, L.D. and Alkon, D.L. (1991) GABA-induced potentiation of neuronal excitation occurs during contiguous pairing with intracellular calcium elevation. Brain Res., (in press).
Miller, R.J. (1986) Protein kinase C: a key regulator of neuronal excitability? Trend Neurosci., 9, 538–41.
Miller, S.G. and Kennedy, M.B. (1986) Regulation of brain type-II Ca2+/ calmodulin-dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch. Cell., 44, 861–70.
Murray, S.A. and Polizotto, S. (1988) Characterization of the morphological, growth, and steroidogenic effect of TPA on mouse Y-1 adrenal cortical tumour cells in culture. Am. J. Anat., 183, 166–77.
Nelson, T.J. and Alkon, D.L. (1990) Specific high molecular weight mRNAs induced by associative learning in Hermissenda. Proc. Natl. Acad. Sci. USA., 87, 269–73.
Nelson, T.J., Collin, C. and Alkon, D.L. (1990) Isolation of a G protein that is modified by learning and reduces potassium currents in Hermissenda. Science, 247, 1479–83.
Nishizuka, Y. (1984) The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature, 308, 693–8.
Nishizuka, Y. (1986) Studies and perspectives of protein kinase C. Science, 233, 305–12.
Pavlov, I.P. (1927) Conditioned reflexes. An investigation of the physiological activity of the cerebral cortex. London: Oxford Unversity Press.
Pinsker, H., Kupfermann, I., Castellucci, V., et al. (1970) Habituation and dishabituation of the gill-withdrawal reflex in Aplysia. Science, 167, 1740–2.
Rose, S.P.R. (1981) What should a biochemistry of learning and memory be about? Neurosci., 6, 811–21.
Sakakibara, M., Alkon, D.L., Neary, J.T., et al. (1986) Inositol trisphosphate regulation of photoreceptor membrane currents. Biophys. J., 50, 797–803.
Waite, M. (1987) The phospholipases. In: Hanahan, D.J. (ed) Handbook of lipid research, vol. 5 London: Plenum Press.
West, A., Barnes, E. and Alkon, D.L. (1982) Primary changes of voltage responses during retention of associative learning. J. Neurophysiol., 48, 1243–55.
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© 1992 S. Nona, J. Cronly-Dillon, M. Ferguson, C. Stafford
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Huddie, P.L., Alkon, D.L., Lester, D.S. (1992). Cellular memory in an invertebrate. In: Nona, S., Cronly-Dillon, J., Stafford, C., Ferguson, M. (eds) Development and Regeneration of the Nervous System. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2348-8_13
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DOI: https://doi.org/10.1007/978-94-011-2348-8_13
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