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Degradation and modification of nucleic acids

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Book cover The Biochemistry of the Nucleic Acids

Abstract

Enzymes which catalyse the breakdown of nucleic acids by hydrolysis of phosphodiester bonds have been found in almost all biological systems [1, 2]. Some, the ribonucleases, are quite specific for RNA, others, the deoxyribonucleases, act only on DNA, whereas a third group of non-specific Nucleases is active against either nucleic acid. The phosphorylases, polynucleotide Phosphorylase and pyrophosphorylase, are also capable of depolymerizing RNA, but their degradative role in vivo is uncertain. The phosphomonoesterases act on polynucleotides or oligonucleotides with a terminal phosphate group or on a mononucleotide to liberate inorganic phosphate. Their substrates will often be the products of nuclease action.

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    Roger L. P. Adams & David P. Leader

  2. Department of Biological Sciences, Glasgow Polytechnic, UK

    John T. Knowler

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Adams, R.L.P., Knowler, J.T., Leader, D.P. (1992). Degradation and modification of nucleic acids. In: The Biochemistry of the Nucleic Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2290-0_4

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