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2,3-Dihydroxy-6-nitro-7-sulphamoyl-benzo(f)quinoxaline, a selective non-N-methyl-D-aspartate excitatory amino acid receptor antagonist, has neuroprotective properties in a model of transient global ischaemia

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Amino Acids

Abstract

NBQX (2,3-Dihydroxy-6-nitro-7-sulphamoyl-benzo(f)quinoxaline) was found to be a potent and selective ligand for quisqualate and kainate receptors.

Furthermore, it is a selective antagonist of non-NMDA responses in the rat neocortex, and of AMPA and kainate evoked neurotoxicity in cultured neurones.

NBQX (30 mg/kg) given pre and post or just post ischaemia, to Mongolian gerbils having received 5 min bilateral carotid artery occlusion, produced a clear neuroprotective effect. This is the first in vivo demonstration of a selective quisqualate/kainate antagonist showing neuroprotective properties.

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Author information

Authors and Affiliations

  1. A/S Ferrosan, CNS Division, Sydmarken 5, DK-2860, Soeborg, Denmark

    Malcolm J. Sheardown, Elsebet Ø. Nielsen, Joergen Drejer & Tage Honoré

Authors
  1. Malcolm J. Sheardown
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  2. Elsebet Ø. Nielsen
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  3. Joergen Drejer
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  4. Tage Honoré
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, University of Vienna, A-1090, Vienna, Austria

    Gert Lubec

  2. T. H. Morgan School of Biological Sciences and The Graduate Center for Toxicology, University of Kentucky, 40506-0225, Lexington, Kentucky, USA

    Gerald A. Rosenthal

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© 1990 ESCOM Science Publishers B.V.

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Sheardown, M.J., Nielsen, E.Ø., Drejer, J., Honoré, T. (1990). 2,3-Dihydroxy-6-nitro-7-sulphamoyl-benzo(f)quinoxaline, a selective non-N-methyl-D-aspartate excitatory amino acid receptor antagonist, has neuroprotective properties in a model of transient global ischaemia. In: Lubec, G., Rosenthal, G.A. (eds) Amino Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2262-7_59

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  • DOI: https://doi.org/10.1007/978-94-011-2262-7_59

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-72199-04-1

  • Online ISBN: 978-94-011-2262-7

  • eBook Packages: Springer Book Archive

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