Abstract
The enantioseparation of α-alkyl-α-amino acids (AAA) was achieved as their N(O)-pentafluoropropionyl S(+)-3-methyl-2-butyl esters by capillary gas chromatography on dimethylpolysiloxane (CP-Sil 5) as the stationary phase. Chiral resolution of AAA and α-hydroxymethyl-a-amino acids was also possible by ligand-exchange chromatography using either a chiral stationary phase in which L-Pro had been bonded covalently to silica (‘Chiral ProCu’), or by use of octadecylsilica as stationary phase and a chiral eluent composed of an aqueous solution of N,N-dimethyl-L-phenylalanine and copper(II)sulfate.
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© 1990 ESCOM Science Publishers B.V.
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Brückner, H. et al. (1990). Enantioseparation of Cα-disubstituted glycines. In: Lubec, G., Rosenthal, G.A. (eds) Amino Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2262-7_19
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DOI: https://doi.org/10.1007/978-94-011-2262-7_19
Publisher Name: Springer, Dordrecht
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