Abstract
In this paper the synthesis of amino acids labelled in different positions with the short-lived positron emitting radionuclide carbon-11 are described. Both aliphatic and aromatic amino acids have been synthesized. To obtain the labelled amino acids enantiomerically pure or enriched in the L-form different approaches such as resolution of racemic mixtures or asymmetric syntheses by chemical or enzymatic methods have been used. The importance of the labelling position in the molecule and some special problems encountered when working with short-lived radionuclides of high specific radioactivity are discussed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Greitz T, Ingvar DH and Widen L (eds.) (1985) The Metabolism of the Human Brain Studied with Positron Emission Tomography. Raven Press, New York.
Hayashi O and Torizaku K (eds.) (1986) Biomedical Imaging. Academic Press, New York.
Phelps ME, Barrio JR, Huang SC, Keen RE, Chugani H and Mazziotta JC (1984) Ann. Neurol. 192.
Lilja A, Bergström K, Hartvig P, Spännare B, Halldin C, Lundqvist H and Långström B (1985) A.J.N.R. 6: 505.
Långström B, Bjurling P and Hartvig P (1989) to be submitted.
Långström B, Antoni G, Gullberg P, Halldin C, Någren K, Rimland A and Svärd H (1986) Int. J. Appl. Radiat. Isot. 37: 1141–1145.
Långström B, Antoni G, Gullberg P, Halldin C, Malmborg P, Någren K, Rimland A and Svärd H (1987) J. Nuc. Med. 28: 1037–1040.
Antoni G and Långström B (1987a) Appl. Radiat. Isot. 38: 655–659.
Fasth KJ, Antoni G and Långström B (1989a) Appl. Radiat. Isot. submitted.
Christman DR, Finn RD, Karlstrom K and Wolf AP (1975) Int. J. Appl. Radiat. Isot. 26: 435.
Antoni G and Långström B (1987b) J. Labelled. Compd. Radiopharm. 24: 125–143.
Antoni G and Långström B (1986) Acta. Chem. Scand. B 40: 152–156.
Antoni G and Långström B (1987c) Acta. Chem. Scand. B 41: 511–517.
Fasth KJ, Antoni G and Långström B (1989b) Acta. Chem. Scand. to be submitted.
Bjurling P, Watanabe Y, Tokushige M, Oda T and Långström B (1989) J. Chem. Soc. Perkin Trans. 1: 1331–1334.
Bjurling P, Watanabe Y, Oka S, Nagasawa T, Yamada H and Långström B (1989) J. Org. Chem. submitted.
Bjurling P, Antoni G, Watanabe Y and Långström B (1989) Appl. Radiat. Isot. submitted.
Iwata R, Ido T, Takahashi T, Nakanishi H and Iida S (1987) Appl. Radiat. Isot. 38: 97.
Gee AD and Långström B (1989) J. Labelled Compd. Radiopharm. 26: 327.
Björkling F, Boutelje J, Gatenbeck S, Hult, Norm T and Szmulik P (1985) Tetrahedron 41: 1347.
Antoni G and Långström B (1989a) J. Labelled Compd. Radiopharm. 27: 571–576.
Antoni G and Långström B (1989b) to be submitted.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 ESCOM Science Publishers B.V.
About this chapter
Cite this chapter
Antoni, G., Bjurling, P., Fasth, K.J., Gee, A., Långström, B. (1990). Synthesis of 11C-labelled amino acids. In: Lubec, G., Rosenthal, G.A. (eds) Amino Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2262-7_15
Download citation
DOI: https://doi.org/10.1007/978-94-011-2262-7_15
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-72199-04-1
Online ISBN: 978-94-011-2262-7
eBook Packages: Springer Book Archive