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Biliary and pancreatic emergencies

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Book cover Glucagon in Acute Medicine

Abstract

Human physiological and pharmacological actions of glucagon on the biliary tract, sphincter of Oddi and pancreas have been well reviewed1,2. Observed effects include stimulation of canalicular bile secretion by an increase in the bile acid-independent fraction with a variable response in bile components1,3,4 independent of innervation5, inhibition of gallbladder motility1, relaxation or ‘spasmolysis’ of both biliary and pancreatic segments of the sphincter of Oddi apparatus1,6,7 independent of its inhibition on gastrointestinal motility, antagonism of opiate-induced hyperactivity of the sphincter of Oddi and duodenum1,6–9 and inhibition of exocrine pancreatic secretion through a number of mechanisms2,10.

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Authors and Affiliations

  1. Director of Endoscopy Gastroenterology Division, Brigham & Women’s Hospital, 75 Francis Street, Boston, Massachusetts, 02115, USA

    Dr. David L. Carr-Locke

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  1. Dr. David L. Carr-Locke
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J. Picazo MD

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© 1993 Springer Science+Business Media Dordrecht

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Carr-Locke, D.L. (1993). Biliary and pancreatic emergencies. In: Picazo, J. (eds) Glucagon in Acute Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2220-7_11

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  • DOI: https://doi.org/10.1007/978-94-011-2220-7_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4984-9

  • Online ISBN: 978-94-011-2220-7

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