New methods for probing the disposition of nicotine in humans
For many centuries nicotine has been consumed by humans in different forms of tobacco. More recently nicotine itself has become available as a pharmaceutical agent in the form of nicotine-containing chewing gum or nicotine preparations for transdermal absorption. The importance of nicotine in human physiology is related to its pleasurable effects as well as to its possible role in tobacco-related disorders. It may be assumed that, as with most pharmacological agents, there is a relationship between plasma concentration of nicotine and its pharmacological effects. It follows that the factors which determine the disposal of nicotine may influence the effects of nicotine during tobacco use as well as its effects when nicotine is used as an adjuvant to smoking cessation. A detailed understanding of whole body and regional disposal of nicotine is of interest with regard to the basic physiology and pharmacology of nicotine. It is noteworthy that literature is almost totally, devoid of information concerning the influence of disease on the pharmacokinetics of nicotine. Thus, data with regard to the influence of, e.g. liver disease or renal disease on nicotine disposal are not available but may well be of clinical interest.
KeywordsPositron Emission Tomography Nuclear Magnetic Resonance Nicotine Concentration Renal Uptake High Infusion Rate
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