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Molecular Chaperones pp 99–106Cite as

Roles of molecular chaperones in protein targeting to mitochondria

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Summary

Molecular chaperones are essential components of the machinery facilitating import of nuclear-encoded proteins into the mitochondria. They act at several steps of the complex import pathway. Cytosolic hsp 70 appears to contribute to maintaining precursors in a translocation-competent conformation. Mitochondrial hsp 70 has a distinct role in driving translocation across outer and inner mitochondrial membranes and probably in supporting unfolding of precursors in the cytosol. Hsp 60 in the matrix is involved in facilitating folding and assembly of imported polypeptide chains.

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Authors
  1. W. Neupert
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  2. N. Pfanner
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Editor information

Editors and Affiliations

  1. Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK

    R. J. Ellis (Professor of Biological Sciences) (Professor of Biological Sciences)

  2. Wellcome/CRC Institute of Cancer and Developmental Biology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QR, UK

    R. A. Laskey

  3. Central Research and Development Department, DuPont Company Experimental, Station E402, Wilmington, Delaware, 19880, USA

    G. H. Lorimer

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© 1993 Springer Science+Business Media Dordrecht

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Neupert, W., Pfanner, N. (1993). Roles of molecular chaperones in protein targeting to mitochondria. In: Ellis, R.J., Laskey, R.A., Lorimer, G.H. (eds) Molecular Chaperones. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2108-8_12

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  • DOI: https://doi.org/10.1007/978-94-011-2108-8_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4935-1

  • Online ISBN: 978-94-011-2108-8

  • eBook Packages: Springer Book Archive

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