Abstract
The application of simple relationships describing substrate uptake and product formation derived from microbial systems, to the growth of hybridoma cells is considered unlikely to assist in the understanding of antibody formation and hence maximising antibody yield. Inadequacies in the current approach to the study of the kinetics of growth of hybridoma cells and antibody production are described and suggestions made as to which approach may be employed to assist in our further understanding of the process.
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Barford, J.P., Phillips, P.J., Marquis, C.P., Harbour, C. (1993). Biosynthesis of Protein Products by Animal Cells - Are Growth and Non-Growth Associated Concepts Valid or Useful?. In: Kaminogawa, S., Ametani, A., Hachimura, S. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2044-9_29
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DOI: https://doi.org/10.1007/978-94-011-2044-9_29
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