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NMR Structural Techniques in Biochemical and Bioinorganic Systems: Paramagnetic Shift and Relaxation Probes

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Recent Experimental and Computational Advances in Molecular Spectroscopy

Part of the book series: NATO ASI Series ((ASIC,volume 406))

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Abstract

The presence of paramagnetic metal centers causes paramagnetic shift and relaxation effects on the resonances of NMR-active nuclei of ligand molecules. The origins of these shift and relaxation effects are analysed theoretically. The contact and dipolar effects, as well as the Curie spin relaxation effects, are illustrated with examples from transition metal-containing metalloproteins, and lanthanides used as extrinsic probes of proteins. In particular, structural information obtainable from lanthanide probes is critically appraised. The NMRD technique of study of nuclear paramagnetic relaxation is presented and illustrated for small Mn(II) and Gd(III) chelates useful as contrast agents for MRI.

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Authors and Affiliations

  1. Department of Biochemistry and Center of Neurosciences, University of Coimbra, 3000, Coimbra, Portugal

    Carlos F. G. C. Geraldes

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  1. Carlos F. G. C. Geraldes
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Editors and Affiliations

  1. Department of Chemistry, University of Coimbra, Coimbra, Portugal

    R. Fausto

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© 1993 Springer Science+Business Media Dordrecht

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Geraldes, C.F.G.C. (1993). NMR Structural Techniques in Biochemical and Bioinorganic Systems: Paramagnetic Shift and Relaxation Probes. In: Fausto, R. (eds) Recent Experimental and Computational Advances in Molecular Spectroscopy. NATO ASI Series, vol 406. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1974-0_18

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  • DOI: https://doi.org/10.1007/978-94-011-1974-0_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4871-2

  • Online ISBN: 978-94-011-1974-0

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