Abstract
Recent evidence has indicated that antagonism of serotonin receptor subtypes may, in part, be responsible for the atypical profile of some antipsychotic drugs. In the past, our lab has investigated the neurobiology of the tridecapeptide neurotransmitter neurotensin (NT). NT has been implicated in the mechanism of action of antipsychotic drugs and the pathophysiology of schizophrenia. Of particular interest is the finding that acute and chronic treatment with clinically efficacious typical antipsychotic drugs selectively increase NT concentrations in the nucleus accumbens and caudate nucleus of rats, while treatment with the atypical antipsychotic clozapine increases NT concentrations in the nucleus accumbens only. Recently, our lab has examined the effects of the putative atypical antipsychotic, sertindole. Sertindole is a potent antagonist of 5-HT2D2anda 1-adrenoreceptors and has a high 5-HT2/D2ratio similar to a number of other atypical antipsychotic drugs. Sertindole mimicked the changes in NT concentration produced by the atypical antipsychotic clozapine. These findings support the hypothesis that sertindole may be an atypical antipsychotic and provide further evidence for the role of serotonin receptor antagonism in the mechanism of action of atypical antipsychotic drugs.
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© 1993 Springer Science+Business Media Dordrecht
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Kinkead, B.L., Owens, M.J., Nemeroff, C.B. (1993). Serotonin Antagonists as Antipsychotics. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_34
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DOI: https://doi.org/10.1007/978-94-011-1920-7_34
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