Abstract
Development of effective antiemetics has depended upon understanding of the emetic reflex arc and identification of significant neurotransmitter receptors within that reflex arc. Appreciation of the role of histaminergic, cholinergic, and dopaminergic receptors led to development of the first generation of antiemetics. The increased efficacy of high-dose metoclopramide (an antidopaminergic agent) was later found to be due at least in part to additional blockade of serotonergic (5-HT3) neurotransmitter receptors. Pure 5-HT3antagonists now allow effective antiemesis without antidopaminergic toxicity. However recent studies concerning dose-response effects and schedule effects with 5-HT3receptor blockers suggest that additional factors must also be identified to fully understand the physiology and pharmacology of chemotherapy-induced emesis and antiemetic activity.
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© 1993 Springer Science+Business Media Dordrecht
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Grunberg, S.M. (1993). Clinical Aspects of Antiemesis: Role of the 5-HT, Antagonists . In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_18
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DOI: https://doi.org/10.1007/978-94-011-1920-7_18
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